23/01/2024
Cancer cells are in part defined by a metabolic switch termed as warb Effect. Where glycolyticcarbon Flux is highly up regulated while Oxidative phosphorylation is significantly down. This is due to factors and depends on the type of the cancer. Pyruvate metabolism. High production of lactate as primary metabolic production end, yet lactate is used to fuel more growth of cancer cells. From pyruvate to lactate generates NAD(Nicotinamide Aden in Dinucleotide) which acid supposed to send lactates out of the cell instead create environment for other cells that support lactate survive the cancer cells continue to be rebellious since the Acidifiction from extracellularenviroment which protects the cancer cells from the immune system. Eg acidification extracellular environment and lactates impair the ability of cytotoxic Lymphocytes, white blood cells which have to remove and expelled or treat deranged cell from the body for cytokine to produce and destroy the cancer cell. Instead they fell the growth no permit to cell growth or division which leads the acids to brake down into tumor. So lactate come joins a fuel cancer cells around tumor now when it is converted back to pyruvate the oxygen levels are higher or surficient to surposed oxidative phosphorylation. Then high glucose is conserved for the cancer cells. So reduce sugar and carbohydrates oils are not a problem. We will chart on keep around. Consultation feel free +27838252922
