Pharmaceutical Solid State Research Cluster

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Pharmaceutical Solid State Research Cluster

The PSSRC aims to initiate and foster collaborative research between its members in all areas of the pharmaceutical solid state field

25/03/2022

Ascertain a minimum coating thickness for acid protection of enteric coatings by means of optical coherence tomography

Enteric coatings are designed to protect active pharmaceutical ingredients (APIs) against untimely release in the stomach. Acid protection of such coa…

24/03/2022

Solvatomorphism in Miconazole: The Role of Weak C–H···Cl Hydrogen Bonds and C–Cl···Cl–C Halogen Interactions in Similarities and Differences in the Crystal Packing

The phenomenon of solvatomorphism in drugs always has its significance in the pharmaceutical industry and in the area of crystal engineering for various reasons. An old antifungal drug, 1-[2-(2,4-dichlorophenyl)-2-[(2,4-dichlorophenyl)-methoxy]ethyl]-1-H-imidazole (Miconazole), with no earlier cryst...

23/03/2022

Preprint: In-Situ Observation of the Structure of Crystallising Magnesium Sulfate Heptahydrate Solutions with Terahertz Transmission Spectroscopy

Terahertz time-domain spectroscopy in a transmission geometry combined with vi- sual analysis was used to investigate the crystallisation process of MgSO4 solution. Careful spectral analysis of both a feature at 1.6 THz and the baseline allowed the ex- traction of information about the liquid phase....

20/03/2022

Elucidating the Dehydration Mechanism of Nitrofurantoin Monohydrate II Using Low-Frequency Raman Spectroscopy

The dehydration of nitrofurantoin monohydrate II was monitored under different isothermal conditions (100, 105, 110, 115, and 120 °C) using Raman spectroscopy in the low- (−300 to 15 and 15 to 300 cm–1) and mid- (300 to 1800 cm–1) frequency regions. Clear and subtle spectral differences were ...

19/03/2022

Embedding a Sensitive Liquid-Core Waveguide UV Detector into an HPLC-UV System for Simultaneous Quantification of Differently Dosed Active Ingredients during Drug Release

Individual dosing of pharmaceutics and personalized medicine have become important with regard to therapeutic safety. Dose adjustments, biorelevant drug release and combination of multiple active substances in one dosage form for the reduction in polymedication are essential aspects that increase th...

17/03/2022

Towards a better understanding of the role of stabilizers in QESD crystallizations

Quasi-emulsion solvent-diffusion crystallization (QESD) is a type of spherical crystallization which can be used as a particle design method to improve the flowability and micromeritic properties of drugs or excipients. Spherical particles are generated by dispersing a solvent phase in an antisolven...

16/03/2022

The Value of Bead Coating in the Manufacturing of Amorphous Solid Dispersions: A Comparative Evaluation with Spray Drying

Despite the fact that an amorphous solid dispersion (ASD)-coated pellet formulation offers potential advantages regarding the minimization of physical stability issues, there is still a lack of in-depth understanding of the bead coating process and its value in relation to spray drying. Therefore, b...

11/03/2022

Pharmaceutical Development of Film-Coated Mini-Tablets with Losartan Potassium for Epidermolysis Bullosa

Epidermolysis bullosa is a genetically heterogenous skin fragility disorder with multiorgan involvement appearing already in newborn children. Severe progressive fibrosis follows skin blistering, mucosa lesions, and wound healing, favouring development of highly aggressive squamous cell carcinomas.....

10/03/2022

Effects of polymer addition on the non-strongly interacting binary co-amorphous system carvedilol-tryptophan

Co-amorphous systems have been developed to address the solubility challenge of poorly water-soluble crystalline drugs. However, due to the thermodyna…

26/02/2022

New Insights into the Crystallographic Disorder in the Polymorphic Forms of Aspirin from Low-Frequency Vibrational Analysis

Terahertz time-domain spectroscopy (THz-TDS) is applied to two polymorphs of acetylsalicylic acid (aspirin), and the experimental spectra are compared to lattice dynamical calculations using high accuracy density functional theory. The calculations confirm that forms I and II have very close energet...

25/02/2022

Flow cell to study crystallisation processes in-situ using terahertz time-domain spectroscopy

A versatile setup based on terahertz time-domain spectroscopy was developed to monitor the process of crystallisation and characterise the structure of the crystals as well as the dynamics of the solvent in situ. The setup can be used to investigate crystallisation processes over a wide range of tem...

24/02/2022

Measuring Solute Concentration with Terahertz Time-Domain Spectroscopy in Single and Multiphase Systems

A versatile setup based on a microfluidic platform allows investigation of liquid samples at various temperatures with terahertz time-domain spectroscopy. The setup is applied to develop a novel method that performs temperature and concentration calibrations of liquid samples at terahertz frequencie...

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