BioViva Sciences Inc

07/10/2025

Canavan disease (CD) is a fatal genetic leukodystrophy caused by mutations in the ASPA gene, leading to accumulation of N-acetylaspartate (NAA) and breakdown of myelin, the insulating sheath around nerve fibers. Affected children suffer progressive neurological impairment, blindness, seizures, and early death.

MYR-101 gene therapy reduces N-acetylaspartate, increases myelin, and improves development in Canavan disease patients.

06/10/2025

Animal studies suggest benefits like reduced inflammation, cancer protection, and neuroprotection, but evidence for anti-aging is weak. Recent research also points to harms, including heart, kidney, and cellular damage.

Ketogenic diet (KD) is widely prescribed for weight management in obese individuals, yet their potential impact on biological aging remains unclear. U…

05/10/2025

The study also investigated how FGF21 communicates with cells. It found that the hormone's activity depends on a protein called β-Klotho, which was also altered in ALS-affected tissues. These changes were especially noticeable in motor neurons and muscle cells under stress, further highlighting FGF21's role in the body's response to damage.

[…]we have identified FGF21 as a novel biomarker in ALS that is detected in multiple compartments including muscle, spinal cord, and

04/10/2025

A research group from the National Cancer Research Center (CNIO) has found that an alteration in the POT1 gene prevents lung tissue from regenerating, which over time makes breathing difficult. The mutation prevents telomeres, the structures that protect chromosomes, from repairing.

A research group from the National Cancer Research Center (CNIO) has found that an alteration in the POT1 gene prevents lung tissue from regenerating, which over time makes breathing difficult. The mutation prevents telomeres, the structures that protect chromosomes, from repairing. According to the...

03/10/2025

Reactivation of mammalian regeneration by turning on an evolutionarily disabled genetic switch

Mammals display prominent diversity in the ability to regenerate damaged ear pinna, but the genetic changes underlying the failure of regeneration remain elusive. We performed comparative single-cell and spatial transcriptomic analyses of rabbits and mice recovering from pinna damage. Insufficient r...

03/10/2025

A little AI with your telomere biology class today...

In Animals: Telomerase Gene Therapy Extends Lifespan Without More Cancer

Unlock the secrets of telomeres and aging with this guide on practical lifestyle choices, testing accuracy, and the latest longevity science.

02/10/2025

First At Home Gene Therapy

Vyjuvek wound gel now approved for newborns, patient and caregiver use

The FDA approved an update to the prescribing information of gene therapy Vyjuvek expanding access to all patients and allowing at-home use.

01/10/2025

POT1 gene mutation linked to pulmonary fibrosis through telomere dysfunction

Idiopathic pulmonary fibrosis is a potentially fatal disease currently without treatment, in which lung tissue develops scarring and becomes stiff, making breathing increasingly difficult over time.

30/09/2025

An international team of researchers led by Duke-NUS has identified rare mutations in the SPNS1 gene as the cause of a previously unrecognized multi-organ disorder.

An international team of researchers led by Duke-NUS has identified rare mutations in the SPNS1 gene as the cause of a previously unrecognized multi-organ disorder. A research team led by Duke-NUS Medical School has uncovered the cause of a rare, previously unidentified disease that affects sever

29/09/2025

Early findings suggest gene therapies for sickle cell disease may help normalize brain blood flow, potentially reducing stroke risk.

Early findings suggest gene therapies for sickle cell disease may help normalize brain blood flow, potentially reducing stroke risk.

28/09/2025

Links for current studies for patients with Primary Immunodeficiency

Access free, up-to-date clinical references on the diagnosis, treatment, monitoring and gene therapy for patients with primary immunodeficiency. Healio's Clinical Guidance offers expert-driven insights to support informed decision-making.

27/09/2025

Every day, human bone marrow produces around 200 billion new red blood cells. But in five to seven out of every million people, that system is severely disrupted