02/07/2025
Serum Copper Level Significantly Influences Platelet Count, Lymphocyte Count and Mean Cell Hemoglobin in Sickle Cell Anemia
Author(s):
Okocha Chide1,John Aneke1,*,Manafa Patrick2,Nwogbo Samuel2,Ibeh Nancy2,Onah Christian3
1Department of Hematology, Nnamdi Azikiwe University Teaching Hospital, Nnewi, Nigeria
2Department of Medical Laboratory Science, College of Health Sciences, Nnamdi Azikiwe University, Nnewi Campus, Nigeria
3Department of Chemical Pathology, Nnamdi Azikiwe University Teaching Hospital, Nnewi, Nigeria
*Corresponding author: Aneke John, Department of Hematology and Blood Transfusion, Nnamdi Azikiwe University Teaching Hospital, PMB 5025, Nnewi, Anambra State, Nigeria. Tel: +234-8063756285, E-mail: anekejc@ymail.com
Zahedan Journal of Research in Medical Sciences:Vol. 18, issue 12; e4117
Published online:Dec 12, 2015
Article type:Research Article
Received:Sep 21, 2015
Accepted:Dec 06, 2016
How to Cite:Chide O, Aneke J, Patrick M, Samuel N, Nancy I, et al. Serum Copper Level Significantly Influences Platelet Count, Lymphocyte Count and Mean Cell Hemoglobin in Sickle Cell Anemia.Zahedan J Res Med Sci.2015;18(12):e4117.https://doi.org/10.17795/zjrms-4117.
Abstract
Background:
Changes in serum micro nutrients levels affect a number of critically important metabolic processes; these could potentially influence blood counts and ultimately disease presentation in patients with sickle cell anemia (SCA).
Objectives:
To evaluate the influence of serum micro-nutrients levels; zinc, copper, selenium and magnesium on blood counts in steady state SCA patients.
Methods:
A cross sectional study that involved 28 steady state adult SCA subjects. Seven milliliters (mls) of blood was collected; 3 mls was for hemoglobin electrophoresis and full blood count determination while 4 mls was for measurement of serum micro nutrients levels, by the atomic absorption spectrophotometry. Correlation between serum micro-nutrient levels and blood counts was done by the Pearson’s linear regression. Ethical approval was obtained from the institutional review board and each participant gave informed consent. All data was analyzed by SPSS software version 20.
Results:
There was a significant correlation between serum copper levels and mean cell hemoglobin (MCH), platelet and lymphocyte counts (r = 0.418; P = 0.02, r = -0.376; P = 0.04 and r = -0.383; P = 0.04, respectively). There were no significant correlations between serum levels of other micro nutrients (selenium, zinc and magnesium) and blood counts.
Conclusions:
Copper influences blood count in SCA patients probably by inducing red cell haemolysis, oxidant tissue damage and stimulating the immune system.
