19/08/2025
 (TB) infection is caused by the bacterium Mycobacterium tuberculosis, primarily affecting the lungs but potentially spreading to other organs. TB is an airborne infectious disease that spreads when a person with active TB coughs, sneezes, talks, or sings, releasing tiny droplets containing the bacteria into the air, which others can inhale.
of TB Infection
1. Primary TB infection: This is the initial stage after exposure. The immune system attempts to capture and destroy the bacteria. Most people do not show symptoms at this stage, though some may experience mild flu-like symptoms such as low fever, tiredness, or cough.
2. Latent TB infection: If the immune system contains the bacteria but does not eliminate them, the bacteria remain dormant within the body without causing symptoms or spreading to others. This stage is asymptomatic, and people with latent TB are not contagious. However, the bacteria can become active later, especially if the immune system weakens.
3. Active TB disease: This occurs when the immune system fails to control the bacteria, allowing them to multiply and cause illness. Active TB usually develops gradually and can cause symptoms such as a persistent cough (sometimes with blood), chest pain, fever, night sweats, fatigue, weight loss, and loss of appetite. People with active TB are contagious and can spread the disease to others.
and Risk Factors
• TB spreads primarily through prolonged close contact with someone who has active lung TB.
• People with latent TB do not spread the infection.
• Risk factors for developing active TB include weakened immune systems (e.g., HIV/AIDS, diabetes), malnutrition, to***co use, alcohol abuse, living in crowded or poorly ventilated conditions, and young age (under 5 years).
and Treatment
• TB infection is diagnosed through microscopic examination of body fluids eg sputum for respiratory TB and molecular techniques for detection of mycobacterial DNA or blood tests (interferon-gamma release assays).
• Active TB requires treatment with multiple antibiotics over several months to fully eradicate the bacteria.
• Adherence to the full course of treatment is crucial to prevent drug resistance and relapse.
• The Bacille Calmette-Guérin (BCG) vaccine is used in many countries to protect children from severe forms of TB.
• Preventive treatment may be offered to people with latent TB who are at high risk of developing active disease.
• Early detection and treatment of active cases, along with screening of high-risk groups, are key strategies to control TB spread.solr