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"There's as many atoms in a single molecule of your DNA as there are stars in the typical galaxy. We are,each of us, a l...
07/05/2025

"There's as many atoms in a single molecule of your DNA as there are stars in the typical galaxy. We are,each of us, a little universe."

[Neil Degrasse Tyson]

CHOCOLATESince time in memorial Chocolate in all its different forms, has been celebrated , sought after , and to a larg...
10/02/2025

CHOCOLATE

Since time in memorial Chocolate in all its different forms, has been celebrated , sought after , and to a large extent , has been highly romanticized.

Most people love chocolate. If you are among the lovers of chocolate (your taste buds chose correctly), then you will probably want to keep reading.

Chocolate, specifically dark chocolate, has long been in the media touting all sorts of health benefits. There is increasing evidence suggesting that beyond being our loved confection, chocolate can affect our mood.

The question that begs then is ,

How does chocolate aid in elevating the mood?

To answer this question, we will localize our focus on three key components of chocolate that are pertinent to our topic

1. PHENYLETHYLAMINE (PEA)

Is an organic compound, natural monoamine alkaloid, and trace amine, which acts as a central nervous system stimulant in humans. It is analogous to the synthetic amphetamine, and is thus a potent neurotransmitter that plays a crucial role in the following,

a) Neurotransmission: PEA acts as a neuromodulator and trace amine neurotransmitter, influencing the activity of classical monoamine
neurotransmitters like dopamine, norepinephrine, and serotonin. PEA stimulates the release of dopamine, norepinephrine, and serotonin, amplifying their effects. It competes with these neurotransmitters for transporters (e.g., dopamine transporter, norepinephrine transporter), thereby leading to increased extracellular levels of dopamine and other monoamines.

b) Mood Elevation: By competitively competing with dopamine for transporters , PEA
increases dopamine levels, contributing to feelings of pleasure and well-being. In addition , by increasing the levels of norepinephrine, PEA enhances cognitive functions like attention and wakefulness.

Phenylethlalanine creates similar feelings to those we feel when we fall in love ,i.e, increased alertness, increased heart rate, and motivation. As such , PEA is aptly dubbed 'The love molecule.'

2. TRYPTOPHAN

Tryptophan is hydroxylated and decarboxylated by the enzymes Tryptophan hydroxylase and 5-OH tryptophan decarboxylase respectively. Once this is done , it leads to the formation of 5-hydroxytryptamine (5-HT) which is also known as serotonin. All this occurs in the raphe nuclei of the brain stem. The metabolite , serotonin, is then released into the synaptic cleft. Serotonin then causes the following

• Inhibition of stress response: Serotonin can reduce the activity of the hypothalamic-pituitary-adrenal (HPA) axis, which is responsible for the stress response.

• Serotonin modulates the activity of other neurotransmitters, such as dopamine, norepinephrine, and GABA, which involved in mood regulation.

3. THEOBROMINE AND CAFFEINE

Theobromine can increase feelings of happiness and relaxation by stimulating the release neurotransmitters like dopamine and serotonin. In addition, Theobromine has been shown to have anxiolytic (anxiety-reducing) properties, which can contribute to improved mood.

Caffeine is a well-known stimulant that can increase alertness, energy and wakefulness.

From the foregoing writing it can be surmised that beyond just being our favorite treat , chocolate is key in regulating our mood.

So the next time she seems off , or seems to be down , you now know what to get her.

References.

https://www.portagepath.org/cocoa-comfort-how-chocolate-sweetens-mental-well-being/

https://www.sciencedirect.com/science/article/pii/S0955286321002746

Scholey A, Owen L. Effects of chocolate on cognitive function and mood: a systematic review. Nutr Rev. 2013 Oct;71(10):665-81. doi: 10.1111/nure.12065. PMID: 24117885.

𝗣𝗦𝗘𝗨𝗗𝗢𝗖𝗬𝗘𝗦𝗜𝗦 Otherwise known as "phantom pregnancy," is a condition where a woman believes that she is pregnant when inf...
01/01/2025

𝗣𝗦𝗘𝗨𝗗𝗢𝗖𝗬𝗘𝗦𝗜𝗦
Otherwise known as "phantom pregnancy," is a condition where a woman believes that she is pregnant when infact she is not. It is a rare psychosomatic disorder, which implies that it is a distortion that affects both the mind and the body.
This false pregnancy has a prominent psychiatric component as well as physical manifestations of pregnancy. Pseudocyesis has roots as far back as the 17th century, however it is only recently though that the medical fraternity has taken an active interest in this anomaly.

1. 𝗖𝗔𝗨𝗦𝗘𝗦
The exact etiology is not fully understood. However, psychological and endocrine components have been noted to play substantial roles; thus some causes are:
*Overwhelming desire of pregnancy
*Overwhelming fear of pregnancy
*Loss of fertility or reproductive capacity
*History of miscarriage
*History of a death of child
*Antipsychotic meds which may induce hormonal changes
*Psychiatric conditions, including depressive disorders, personality disorders, and schizophrenia.

The aforementioned may exist independently or exist in unison; causing pseudocyesis.

2. 𝗥𝗜𝗦𝗞 𝗙𝗔𝗖𝗧𝗢𝗥𝗦
*Low educational status
*Marital issues, unstable relationship patterns
*History of partner abuse
*Social deprivation, poverty, lower socioeconomic status, and unemployment
*Recurrent miscarriages, stress of imminent menopause, tubal ligation sterilization surgery, and hysterectomy.

𝟯. 𝗦𝗜𝗚𝗡𝗦 𝗔𝗡𝗗 𝗦𝗬𝗠𝗣𝗧𝗢𝗠𝗦
*Amenorrhea (missed periods)
*Galactorrhea (flow of milk from breast)
*Breast enlargement
*Weight gain
*Abdominal growth(otherwise known as abdominal distention is the most common presentation)
*Sensations of fetal movement and contractions
*Nausea and vomiting
*Frequent urination.

4. 𝗗𝗜𝗔𝗚𝗡𝗢𝗦𝗜𝗦 𝗔𝗡𝗗 𝗠𝗔𝗡𝗔𝗚𝗘𝗠𝗘𝗡𝗧
In some cases, pseudocyesis may resolve promptly when the underlying causes/stressors are addressed.

If that is not the case, it is important to rule out a viable pregnancy by carrying out:
*A pelvic exam
*A blood or urine test
*An Obstetric Ultrasound.

Differentials of pseudocyesis includes:
*Hyperprolactinemia
*Hormone-secreting tumors
*Gallstones
*Constipation

Additional interventions such as psychotherapy and pharmacotherapy are sometimes needed to help the patient come to terms with the false pregnancy.

Kind regards,
Erick Mudenda IV

Address

Ndola

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