Nugenis

NUGENIS hat den EBP-Epigenetic Brain Protector® entwickelt und für den Schutz der Gehirnzellen ein

NUGENIS ist ein junges Startup, das unter anderem mit dem innovativen EBP® - Epigenetic Brain Protector auf dem österreichischen Markt vertreten ist. Unsere Kernkompetenzen liegen in unserer Partizipation an internationalen Forschungsgruppen, unserer jahrelangen Erfahrung im Bereich der Angewandten Epigenetik. Unser erstes Produkt ist zugleich Goldmedaillen-Gewinner (2015) auf der international renommiertesten Innovations- und Erfindermesse, der iENA in Nürnberg für herausragende Leistungen im Bereich des Schutzes gegen Neurodegeneration. NUGENIS steht für Innovation, wissenschaftliches KnowHow und kurze Wege von der Forschung zum fertigen Produkt. Auf www.nugenis.eu finden sich nähere Informationen zur Forschung im Bereich der Angewandten Epigenetik.

22/11/2025

"Seine Gedanken beherrschen die USA" titelt DIE ZEIT (N°48, 13. November 2025) und Nicolas Killian fragt "Warum spricht der einflussreiche Milliardär Peter Thiel ständig vom Antichrist?
1. Was ist Neo-Integralismus?
Der Neo-Integralismus ist eine in den USA wiedererstarkende Strömung, die an den katholischen Integralismus des frühen 20. Jahrhunderts anknüpft.Ihre Kernidee lautet:

Die liberale Moderne ist gescheitert; eine gerechte Ordnung erfordert die Re-Integration von Politik und Religion.

Die zentralen Motive:

Ablehnung des Liberalismus als „wertneutraler“ Ordnung.

Rückkehr zu metaphysisch begründeter Herrschaft.

Betonung hierarchischer, autoritärer Strukturen.

Kritische Haltung gegenüber Demokratie und Pluralismus.

Politische Theologie als normative Grundlage politischer Ordnung.

Der Neo-Integralismus ist damit ein Gegenentwurf zu liberal-demokratischer Modernität und sucht nach einem transzendent fundierten politischen Projekt.

2.

"Seine Gedanken beherrschen die USA" titelt DIE ZEIT (N°48, 13. November 2025) und Nicolas Killian fragt "Warum spricht der einflussreiche Milliardär Peter Th

19/11/2025

Antibiotika-Resistenz gilt traditionell als Folge genetischer Mutationen oder des Erwerbs resistenzvermittelnder Gene über Plasmide. Doch moderne Forschung zeigt:
Epigenetische Mechanismen spielen eine zentrale Rolle dabei, wann und wie stark Resistenz entsteht — oft lange bevor genetische Veränderungen auftreten.
Bakterien nutzen epigenetische Systeme, um sich blitzschnell an toxische Umgebungen anzupassen, ihre Genexpression umzustellen und Überlebensprogramme zu aktivieren.

- DNA-Methylierung als schneller Resistenz-Schalter

Bakterien besitzen ein hochentwickeltes System aus DNA-Methyltransferasen (Dam, Dcm), die Methylgruppen auf Adenin- oder Cytosinbasen setzen.

Diese Markierungen steuern:

- Promotoraktivität resistenzrelevanter Gene (z. B. Effluxpumpen, Membranproteine).
- Umschalten zwischen hohen und niedrigen Expressionszuständen.
- Überlebensprogramme bei Stress, etwa SOS-Response oder Biofilm-Bildung.

Beispiel:
E.
#•AntibiotikaresistenzMechanismen #•Biofilmepigenetischreguliert #•DamMethyltransferaseResistenz #•DNAMethylierungBakterien #•epigenetischeAntiResistenzTherapien #•epigenetischeAntibiotikaResistenz #•epigenetischePräResistenz #•epigenetischeSchalterBakterien #•PersisterZellenEpigenetik #•PhaseVariationResistenzmechanismen

Antibiotika-Resistenz gilt traditionell als Folge genetischer Mutationen oder des Erwerbs resistenzvermittelnder Gene über Plasmide. Doch moderne Forschung zei

12/11/2025

Opening: The Electric Language of Life
The nervous system is not merely a communication network; it is the living interface between perception and biology. Every thought, every sensation, every memory translates into molecular signals — neurotransmitters, ions, and growth factors — that reshape the epigenetic landscape of neurons and glial cells. This dialogue between electricity and chemistry makes the brain’s plasticity possible. It is where the immaterial becomes material, and where experience leaves a biological signature.

Synaptic Plasticity and Memory Encoding
When neurons fire together, their connections strengthen — a process known as long-term potentiation (LTP). Yet beneath the electrical pulse lies an epigenetic script: DNA methylation, histone acetylation, and microRNA modulation fine-tune the transcription of genes essential for synaptic growth. The BDNF gene, a key regulator of neuronal resilience, is epigenetically activated through experience and learning.
–bodyconnection

Opening: The Electric Language of Life The nervous system is not merely a communication network; it is the living interface between perception and biology. Eve

04/11/2025

Introduction: The Fractured Symphony of Life

Health is the art of coherence — the ongoing dialogue between Ich-Welt, Wir-Welt, and Umwelt.
When one of these dimensions falls out of tune, the others soon follow.
The collapse of individual resilience mirrors the erosion of social trust and the degradation of the biosphere.
In molecular terms, it is one process: the loss of rhythmic balance in the network of life.

The three enemies of life — self-conflict, social dissonance, and ecological chaos — are not independent.
They are the same melody played in different octaves: psychological, social, planetary.

- The Self: Molecular Disintegration through Inner Conflict

When inner dialogue becomes self-attack, stress hormones replace serenity.
Cortisol, MAO-B, and oxidative radicals act as chemical agents of alienation.
The epigenome, once fluid and adaptive, hardens into a defensive script.
Genes of trust and creativity fall silent; those of vigilance and inflammation awaken.

Introduction: The Fractured Symphony of Life Health is the art of coherence — the ongoing dialogue between Ich-Welt, Wir-Welt, and Umwelt. When one of the

28/10/2025

The placebo effect has long been treated as an illusion—something that “tricks” the mind into healing itself. Yet modern science reveals a deeper truth: the placebo is not deception; it is a conscious invitation to the body’s own intelligence. Even when patients are told that they are taking an open placebo—a capsule with no active ingredient—their pain can diminish. Awareness does not weaken the effect; it refines it.

In a Harvard study on chronic back pain, participants knowingly took inert pills labeled “Placebo.” Still, they reported significant relief and improved mood. Functional brain imaging showed activation of the prefrontal cortex, the anterior cingulate cortex, and the periaqueductal gray—the same neural pathways engaged by genuine opioid analgesics. Something profoundly biological was happening—without chemistry, without deception.

Expectation is not just a psychological event; it is a biological one.

The placebo effect has long been treated as an illusion—something that “tricks” the mind into healing itself. Yet modern science reveals a deeper truth: t

24/10/2025

The Interface of Life
Every cell lives at the boundary between self and world. Its membrane defines identity, yet survival depends on a continuous dialogue across that boundary. Through channels and transporters, the cell negotiates with its environment — receiving nutrients, exchanging signals, releasing neurotransmitters. These gates are not fixed. Their permeability is dynamically regulated by epigenetic mechanisms that adapt the rhythm of exchange to stress, nutrition, and emotional state. In this sense, membrane transporters are the executive tools of the epigenome — where molecular memory becomes cellular behavior.

Serotonin Transport and Emotional Regulation
The SLC6A4 gene encodes the serotonin transporter (SERT), responsible for clearing serotonin from the synaptic cleft. Its promoter methylation is one of the best-established epigenetic marks in psychiatric research.

The Interface of Life Every cell lives at the boundary between self and world. Its membrane defines identity, yet survival depends on a continuous dialogue acr

17/10/2025

Lessons from Twins
Twins are nature’s mirror—a living experiment in sameness and divergence. Identical twins begin as one fertilized egg, one shared genome, one biological text duplicated in perfect sequence. Yet as life unfolds, the two copies drift apart. Their laughter may echo the same rhythm, but their biology begins to hum in different keys. What starts as genetic identity becomes an epigenetic conversation: two versions of the same story, annotated by experience.
Epigenetic Divergence: From One Genome to Two Lives
From the perspective of epigenetics, twins embody the dialogue between the Ich-world, the We-world, and the Umwelt. The Ich-world—the inner realm of perception and feeling—interprets the shared environment differently in each twin. The We-world—the relational field of family, peers, and culture—feeds each sibling with distinct emotional and social nutrients.
#•DNAmethylation

Lessons from Twins Twins are nature’s mirror—a living experiment in sameness and divergence. Identical twins begin as one fertilized egg, one shared genome

13/10/2025

For decades, biology was guided by a powerful metaphor: DNA as the “book of life.” The double helix seemed to contain every instruction for the formation of a living being. Yet as scientists began decoding the human genome, a surprising realization emerged—genes alone could not explain the complexity of life, behavior, or disease. The genome provides the letters, but life writes the story.

The Limits of Genetic Determinism
Early genetic models assumed a one-to-one relationship between genes and traits. But the Human Genome Project shattered that illusion: humans possess only about 20,000 protein-coding genes—barely more than a roundworm. If DNA were destiny, we would expect a far simpler creature. The missing information lies not in the sequence itself but in how it is read. Identical twins, born with the same DNA, can differ profoundly in health, personality, and lifespan. Their divergence arises from molecular marks that regulate gene expression without altering the code.
#•DNAmethylation

For decades, biology was guided by a powerful metaphor: DNA as the “book of life.” The double helix seemed to contain every instruction for the formation of

07/10/2025

Bones and Muscles as Epigenetic Witnesses

The musculoskeletal system is often seen as a structural scaffold, but it is in fact a living archive of activity, nutrition, and age. Bones and muscles register the stresses of daily life, the nutrients we consume, and the resilience or fragility shaped by epigenetic programming.

Epigenetics of Muscle Development and Plasticity

Skeletal muscle is characterized by extraordinary adaptability. Myogenesis is directed by transcription factors such as MyoD and Myf5, whose activity is epigenetically regulated by histone modifications. Satellite cells, the muscle’s resident stem cells, depend on DNA methylation and microRNAs for activation and regeneration. Physical training induces histone acetylation in genes governing oxidative metabolism, while inactivity leads to repressive marks and atrophy.

Bones and Muscles as Epigenetic Witnesses The musculoskeletal system is often seen as a structural scaffold, but it is in fact a living archive of activity,

03/10/2025

Introduction: A Small Molecule with Vast Influence
S-adenosylmethionine (SAM-e) is a small molecule with vast biological reach. As the universal methyl donor, it influences DNA, RNA, histones, neurotransmitters, and membranes. This positions SAM-e at the intersection of metabolism, epigenetics, and clinical medicine.
Biochemistry and Epigenetics
SAM-e is synthesized in the liver from methionine and ATP. It donates methyl groups for multiple processes:
- DNA methyltransferases (DNMTs): regulating gene silencing and activation.
- Histone methylation: shaping chromatin structure and transcription.
- Neurotransmitter metabolism: supporting serotonin, dopamine, and norepinephrine pathways.
After methyl transfer, SAM-e is converted to S-adenosylhomocysteine (SAH), which is then metabolized to homocysteine, requiring folate, vitamin B12, and B6 for recycling.
#•SAMeAlzheimer #•SAMeantidepressant #•SAMebenefits #•SAMedepression #•SAMeepigenetics #•SAMejoints #•SAMeliver #•SAMemethylation #•SAMequality #•SAMesideeffects

Introduction: A Small Molecule with Vast Influence S-adenosylmethionine (SAM-e) is a small molecule with vast biological reach. As the universal methyl donor,

27/09/2025

Red ThreadBalance is the essence of life. The endocannabinoid system (ECS) is a master regulator of stress, mood, pain, and immunity — and epigenetics decides how sensitive or resilient this system becomes.

Case VignetteA young man suffers from chronic anxiety and inflammatory bowel disease. His genetic tests show nothing remarkable, but his history tells the story: childhood trauma, poor diet, long-term stress. These experiences did not alter his DNA, but they left epigenetic scars on his endocannabinoid receptors and enzymes. His ECS now overreacts to stress signals and underperforms in inflammation control. With targeted nutrition, stress reduction, and phytocannabinoids, part of this epigenetic imbalance can be rewritten.

Main Text

1. The Architecture of the Endocannabinoid System

Endocannabinoids: Anandamide (AEA) and 2-AG, produced on demand.

Receptors: CB1 (brain, nervous system), CB2 (immune system, periphery).

Red ThreadBalance is the essence of life. The endocannabinoid system (ECS) is a master regulator of stress, mood, pain, and immunity — and epigenetics decides

20/09/2025

Red Thread

The human soul, as Erich Fromm saw it, is not a metaphysical mystery but the dialectical essence of being: love and fear, freedom and dependence, creation and destruction. Epigenetics reveals how these opposing forces leave molecular traces. The dialectic of the soul and the biology of gene expression mirror each other.

Essay

Philosophers once spoke of the soul as immaterial, beyond biology. Erich Fromm broke with this. For him, the soul was dialectical: a space of contradictions that defines human existence. The tension between love and aggression, freedom and conformity, joy and despair — these were not errors to be eliminated but the very conditions of being human.

Epigenetics adds a new lens. What Fromm described in psychological and ethical terms can be seen in biology as epigenetic inscriptions of lived experience. The soul’s contradictions are mirrored by the genome’s plasticity.

Red Thread The human soul, as Erich Fromm saw it, is not a metaphysical mystery but the dialectical essence of being: love and fear, freedom and de

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