17/02/2026
🫀⚖️ High-risk coronary plaques: intervene early—or hold the line?
This 2026 EuroIntervention Viewpoint by Mintz & Collet delivers a sober, evidence-driven answer to one of interventional cardiology’s most debated questions: should we prophylactically stent “high-risk” plaques, or manage them medically and wait?
🔍 What defines a high-risk plaque?
Across invasive and non-invasive imaging, features such as large plaque burden, small MLA, thin-cap fibroatheroma, large lipid core, low-attenuation plaque, positive remodelling, napkin-ring sign, and spotty calcification consistently associate with future events. Lesions with multiple features are riskier—but here’s the catch 👇
📉 Absolute risk is low
Despite ominous imaging, annual hard event rates (death/MI) are ~1%, and most plaque ruptures are clinically silent, contributing to progression rather than ACS. This reframes the entire preventive-PCI debate.
🧪 What do randomized trials show?
PROSPECT ABSORB and PREVENT tested preventive PCI vs optimal medical therapy (OMT).
PCI improved lumen dimensions and reduced future revascularizations, but did not reduce death or MI at 2, 4, or 7 years.
In PREVENT, 739 PCIs prevented only 20–36 later PCIs—a poor trade-off.
Meta-analysis confirms: benefits are driven by fewer procedures, not fewer hard events.
⏳ What happens if we wait?
Long-term follow-up (PROSPECT II, PREVENT) shows very low event rates with OMT and delayed PCI when symptoms arise, avoiding most upfront interventions without penalty.
🧠 Where the field is heading
The authors advocate a “hold-the-line” strategy:
Detecting high-risk plaque should trigger intensified medical therapy and surveillance, not automatic PCI.
Future precision may come from integrating imaging + physiology + inflammation, to identify the rare plaques whose rupture truly matters.
🔮 Bottom line
Until we can predict **which plaques will cause death or MI—not just progression—**the data favor medical therapy first, PCI later if needed.
Seeing risk ≠ fixing it with a stent 🚀