Tracey Yeend - Hormonal, Nutritional & Environmental Health

17/10/2025

It’s never too late to start over. Even if it feels far away, little steps forward matter. You haven’t missed your chance - even if it looks different from what you once wanted. You can still find love, happiness, fulfillment, purpose.

16/10/2025

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16/10/2025

Folic acid, a synthetic pre-vitamin form of folate (vitamin B9), remains both temperature and pH stable, allowing for easy addition to processed foods and multivitamins.

- First, folic acid must be reduced to dihydrofolate by using the DHFR enzyme.
- Secondly, the DHFR enzyme converts dihydrofolate into tetrahydrofolate (the active version used by the body).

Tetrahydrofolate, along with the MTHFR enzyme, is required in a critical step within the methylation pathway. This vital pathway’s responsibility includes creating the methyl groups needed in DNA synthesis, detoxification reactions, the creation of certain neurotransmitters, and more.

Often when reading about folic acid, you will see it mentioned that it is a non-toxic, water-soluble vitamin. This may lead some to assume that extra folic acid won’t hurt you. But this may not be the correct assumption….

The unused folic acid can often be found in the bloodstream as unmetabolized folic acid. There are concerns that excess folic acid could inhibit the DHFR enzyme from converting dihydrofolate into tetrahydrofolate when the body is needing it. Both reactions use the DHFR enzyme, but most of the time, the enzyme is preferentially used for creating the active form (tetrahydrofolate) when needed. Some studies indicate too much unmetabolized folic acid, though, inhibits DHFR from completing that second reaction. This could leave cells lacking in tetrahydrofolate when high levels of folic acid are in circulation.[PMC3317000]

There are also concerns that excess folic acid intake could downregulate folate transporters in the kidneys and intestines.[PMC3317000]

While at first glance, it may seem that people with MTHFR 677 and 1298 variants may gain some kind of benefit from folic acid as long as their DHFR gene is working well, this may not be the case. The studies on high levels of unmetabolized folic acid decreasing the conversion to tetrahydrofolate would indicate that people with MTHFR variants would be at an increased risk for not having enough active folate for the methylation cycle. So caution may be warranted on not taking high doses of folic acid regularly if you have the MTHFR variants. A February 2025 study found that folic acid supplementation for pregnant women with the C677T variant led to an increase in unmetabolized folic acid. [PMC11930790]

Another recent study showed that, regardless of MTHFR status, [6S]-5-MTHF (methyl folate) had higher bioavailability than folic acid.[PMC2807663]

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This is just a short excerpt from my in-depth article on DHFR and MTHFR. Here is my full article: https://www.geneticlifehacks.com/folic-acid-supplementation-and-your-genes/

With a Genetic Lifehacks membership, you can use your genetic raw data (from 23andMe, AncestryDNA, etc) to see your genotypes in over 400 articles, including my article on DHFR and MTHFR. You will see research-backed solutions in the lifehacks section to help determine what pathway to target -- all based on your genetic variants. Personalize your health!

16/10/2025

Happy Thursday 💞

16/10/2025

So funny…
Ageing is not for the faint heated
😂😂😂

😅

16/10/2025

• A JOYful Suggestion • Keep talking passionately about all the things you really love. When you focus on the things that bring you joy, you set the stage to draw more of it into your life. ~unknown

Sherri ❤️🍂❤️ Incredible JOY

15/10/2025

https://omny.fm/shows/evenings-with-matthew-pantelis/interview-tracey-yeend-gynaecologist-dr-farbia-behnia-willison

Listen live on the FIVEAA Player. Follow us on Facebook, X and Instagram. Subscribe on YouTube

15/10/2025

There’s way more to the ovaries than follicles and egg cells. They’re also home to nerves (particularly sympathetic nerves), glial cells (yes, like in the brain!), and fibroblasts that provide structure and support.

A new study suggests those “supporting” cells may play a key role in ovarian aging.

Article: https://www.newscientist.com/article/2499537-hidden-ecosystem-of-the-ovaries-plays-a-surprising-role-in-fertility/

15/10/2025

Interesting

Your health is the physical manifestation of every special interest group’s quest to get rich for the past 8 decades. Thanks, Dow Chemical.

15/10/2025

15/10/2025

Every delay in your life right now is refinement, not resistance. ❤️