William Makis ONC, Alberta Avenue, Edmonton AB, QLD, Australia, Alberta (2026)

09/01/2026

NEW ARTICLE: MEBENDAZOLE in Ovarian Cancer - How does it work? New 2025 Paper from Indian Researchers - 7 mechanisms including a brand new one

MY TAKE…

This study identifies at least 7 ways that Mebendazole acts on Ovarian Cancer cells, including a brand new mechanism never before identified, showing how much we still have to learn:

1. Anti-Proliferation

MBZ stops cancer cells from growing better than cisplatin
Both drugs slowed down cell growth, but MBZ was 3–4 times stronger (needed much less drug to get the same effect).

2. Anti-Metastasis

MBZ stops cancer from spreading
MBZ did this by messing up the cells’ “skeleton” (actin and microtubules), blocking enzymes (MMP-9) that help cancer eat through tissue, and reversing a process called EMT that makes cells more mobile and aggressive.

3. Anti Cancer Stem Cells

Cancer stem cells are special cancer cells that act like seeds — they regrow tumors and resist treatment.
MBZ blocked expression of Cancer Stem Cell markers, lowering the # of Cancer Stem Cells that can develop

4. Cell Cycle Arrest

MBZ freezes cells in a vulnerable stage and kills them
It trapped cells in the G2/M phase of the cell cycle (right before they divide), making them easier to kill.

5. Damage to Mitochondria and 6.Apoptosis

MBZ damaged the cancer cells’ power plants (mitochondria)
Process is called mitochondrial membrane potential disruption
This triggered apoptosis (programmed cell death) - detected by higher levels of “kill signals” like Bax, cleaved caspases and lower survival signals

7. Inhibition of NF-kB (Novel mechanism)

MBZ blocks a key survival pathway (NF-κB and related signals)

NF-κB is a master switch that helps cancer cells grow, spread, resist chemo, and hide from the immune system.

MBZ turned this pathway off, including a protein called Girdin that boosts it — this appears to be a new way MBZ fights cancer.

KEY POINT:

Oncologists don’t read new research.

That’s why they are so ignorant about new possibilities, and the potential of repurposed drugs.

This paper came out in 2025.
Every Oncologist should know it.
I bet you not a single one does! 😉

09/01/2026

NEW ARTICLE: IVERMECTIN, MEBENDAZOLE and FENBENDAZOLE Testimonial - 49 year old woman in IRELAND with Stage 4 Ovarian Cancer reports after 6 months - doing much better than Oncologists expected!

This time I surprised an Oncologist in IRELAND!! 😃

STORY:
49 year old woman in IRELAND with Stage 4 Ovarian Cancer

In May 2025 she started:

Ivermectin 1mg/kg/day
Mebendazole 1000mg/day

KEY POINTS:

“Oncologists thought I would not respond to chemotherapy”

Always write these thoughts down. The Oncologists will tell you the failure they expect because they get paid regardless and no one checks their failures.

After 6 months: tumors are all shrinking and patient feels great with lots of energy and has not experienced pain in 4 months.

"Cancer in lining of colon...reduced"
"Cancer in lining of liver...reduced"
"Overall, I feel great with lots of energy, have experienced no pain since August"

I have the world's largest Ivermectin Cancer Clientele

05/01/2026

NEW ARTICLE: IVERMECTIN and MEBENDAZOLE Testimonial - 55 year old California man with Stage 4 Colon Cancer reports after 6 months - all tumors are shrinking!

55 year old California man with newly diagnosed Stage 4 Colon Cancer, diagnosed on colonoscopy done late May 2025.

In July 2025 he started:

Ivermectin 1mg/kg/day
Mebendazole 1500mg/day
CBD Oil 100mg/day
MCP 15g/day

Oncologist: FOLFOX Chemo and Amivantamab from end of August

KEY POINTS:

After 6 months, Colon Tumor primary shrunk from 7cm to 3cm length and 1.6cm to 0.8cm thickness

Largest liver metastasis shrunk from 9.3x6.5cm to 6.9x5.3cm

What we see here is a good synergy between Ivermectin, Mebendazole and chemotherapy.

Most newly diagnosed Colon Cancers respond well to repurposed drugs and I would say the ones that don’t are further along in the progression of the disease.

Once you get metastases beyond the liver, it becomes difficult to manage and once you’ve been through multiple rounds of chemo (and failed) or have had recurrences, it also becomes difficult to manage and success rate goes down.

This is another area where Clinical Trials will help us understand more 😃

I have the world's largest Ivermectin Cancer Clientele.

05/01/2026

NEW ARTICLE: IVERMECTIN and FENBENDAZOLE Testimonial - 68 year old Louisiana woman with Stage 3 Endometrial Cancer operated, reports after 3 months, residual disease eliminated with NO CHEMO!

🚨TRIGGER WARNING!! No chemo, no radiation, no conventional Oncology involved here!! 😱

These are the stories that Big Pharma bots avoid like the plague because they can't say "it was chemo".

STORY:
68 year old Louisiana woman with Stage 3 Endometrial Cancer operated Jun.23, 2025 (hysterectomy)

In September 2025 she started:

Ivermectin 1mg/kg/day
Fenbendazole 1100mg/day

Results after 3 months:

CA125: 77 (pre-op) to 20 (post-op) to 6 to 5
SIGNATERA: 0.05 (post-op Aug.22) to 0.00

PET/CT: Right inguinal lymph node metastasis 1.5cm SUV 9.1 (Aug.27) shrunk to 1.0cm SUV 2.1 (Dec.10) (typically called normal by radiologists).

KEY POINTS:

Stage 3 Endometrial Cancer patient had a small amount of residual cancer after hysterectomy in June 2025.

She took no chemo, no radiation, no immunotherapy, no conventional treatment after Hysterectomy.

After 3 months of Ivermectin and Fenbendazole, her residual cancer has resolved completely, as measured by CA125, SIGNATERA (circulating tumor DNA) and PET/CT. 😱

Mainstream Oncology tells us this is IMPOSSIBLE!

This completely upends the theory of Modern Cancer Care, where patients with very small amount of residual cancer after surgery still have chemotherapy, radiation and other treatments forced on them.

We are revolutionizing Cancer Research and Cancer Care!

Largest Ivermectin Cancer Clientele in the world!

05/01/2026

NEW ARTICLE: IVERMECTIN and MEBENDAZOLE Testimonial - 56 year old North Carolina man with CLL Leukemia reports after 8 months - normalization of blood work, Oncologist changes follow-up from 3 to 6 months

Leukemia success stories are amazing because mainstream Oncology claims NOTHING helps outside chemo 😃

STORY:
56 year old North Carolina man with CLL Leukemia

In May 2025 he started:

Ivermectin 1mg/kg/day
Mebendazole 1000mg/day
CBD Oil 100mg/day

Results over 8 months:

WBC 13.3 to 12 to 10.7 to 10.0
Lymphocytes: 10.11 to 6.24 to 4.39

KEY POINTS:

Leukemias are tricky cancers

Some CLL cases respond amazingly and obviously to repurposed drugs, while others don’t seem to.

There is still a lot of research work to be done in this area, hopefully in Florida! 😉

What an easy solution this case was! No chemo! 😱

I have the world's largest Ivermectin Cancer Clientele, 7900 strong!! 🙏

05/01/2026

NEW ARTICLE: CHAGA MUSHROOM (Inonotus Obliquus) in CANCER - 2023 Canadian Review Paper

Chaga Mushroom triterpenoids as adjuncts to minimally invasive cancer therapies: A review (2023 Plehn et al.)

HIGHLIGHTS:

Chaga mushroom (Inonotus obliquus) is a parasitic white rot fungus in the Hymenochaetaceae family that grows on birch trees

After a suitable living host tree incurs an injury, Chaga mushroom penetrates the wound where decay spreads throughout the heartwood

Chaga mushroom is widely available in the cold circumboreal regions of the northern hemisphere and has been consumed for centuries, especially by Khanty people in Russia, for health maintenance

Chaga mushroom sclerotium is typically harvested during the winter months for the retrieval of bioactive compounds which have been acclaimed to exhibit protective effects against diabetes, inflammation, hepatoxicity and cancer.

Chaga mushroom’s oily (lipophilic parts) have anti-cancer compounds: Triterpenoids and Sterols are being currently researched due to their prominent cytotoxicity toward various cancer cell types without impacting normal cells.

Dark texturized outer layer of Chaga mushroom tends to be discarded during harvest but contains higher concentrations of betulinic acid and inotodiol in relation to the interior

Lung cancer, breast cancer, methotrexate-resistant colorectal, melanoma, carcinoma of nasopharynx, hepatocellular carcinoma, lymphocytic leukemia, and prostate cancer cells have shown significant susceptibility to Chaga triterpenoids.

In some cases, triterpenoids have demonstrated inhibitory concentrations similar to conventional drugs alone

Cervical Cancer (HeLa Cells) treated with inotodiol were inhibited almost to same extent as those treated with chemo (5-FU)

Synergy:
Standard breast cancer treatment drugs tamoxifen, lapatinib, and doxorubicin combined with inotodiol- and trametenolic acid-enriched fractions displayed synergistic or additive cytotoxic effects

Strongest Anti-Cancer Effects:

Against Colon Cancer (HT29-MX): Chaga’s betulinic acid

Against Lung Cancer (A549): Chaga’s inonotsutriol E

MY TAKE….

Overall, the paper concludes that Chaga triterpenoids could be a useful add-on (adjunct) to gentler, less invasive cancer therapies like targeted treatments or immunotherapy, potentially improving outcomes with fewer side effects.

05/01/2026

BREAKING NEWS: IVERMECTIN and FENBENDAZOLE Testimonial - 34 year old SLOVENIA man with Stage 4 Colon Cancer gives update after 6 months!! Oncologist shocked - near complete response, from a liver FULL of Cancer!

This is a case that will be in HISTORY BOOKS! 😃

You know that feeling when you are witnessing history? This is one of those situations. 😉

STORY:
34 year old SLOVENIA man with Stage 4 Colon Cancer and liver FULL of cancer

In June 2025 he started

Ivermectin 1mg/kg/day
Fenbendazole 444mg/day increasing to 1000mg/day
Chemo (FOLFOX, Cetuximab)

Results after 6 months: Almost complete response!

"I think you will be excited to hear, that I made from the edge of the abyss to having liver being resectable. I attach MRI to see what 12 cycles of chemo did in conjunction with the Ivermectin and other supplements and therapies"

"I started with 20+ metastases, 3 of them being almost 10cm big!"

KEY POINTS:

“My doctor said "she has only seen such a good response in the literature, but never with her own eyes." "

“My doctor said in the beginning that getting a complete response for a solid colorectal tumor with just a chemotherapy is basically impossible or very rare. However that is exactly what happened right now, or very close to it.”

“I am taking more than in the protocol of the turkey tail mushroom (4g per day) and I added Lion's mane mushroom (2g per day) as well.

I have zero side effects from 5FU or Oxaliplatin, which is also unusual, because I did have side effects from Oxaliplatin on my 3. and 4. cycle, but since I am taking the mushroom supplements, the side effects disappeared.”

“I take high dose of Turkey tail mushroom, about 5g per day and Chaga, and I think that helps me a lot to sustain my immune system.”

Can you take Ivermectin and Fenbendazole when the liver is FULL of cancer?

You can see clearly, the answer is YES!!

This is a history-making case.

I have the world's largest Ivermectin CANCER CLIENTELE, 7900+ Cancer patients from around the world!

I send my love to SLOVENIA and it's people! 🙏

I send my love to FLORIDA and the site of the FUTURE of Cancer Care!! 😃

05/01/2026

BREAKING NEWS: IVERMECTIN and FENBENDAZOLE Testimonial - 34 year old SLOVENIA man with Stage 4 Colon Cancer gives update after 6 months!! Oncologist shocked - near complete response, from a liver FULL of Cancer!

This is a case that will be in HISTORY BOOKS! 😃

You know that feeling when you are witnessing history? This is one of those situations. 😉

STORY:
34 year old SLOVENIA man with Stage 4 Colon Cancer and liver FULL of cancer

In June 2025 he started

Ivermectin 1mg/kg/day
Fenbendazole 444mg/day increasing to 1000mg/day
Chemo (FOLFOX, Cetuximab)

Results after 6 months: Almost complete response!

"I think you will be excited to hear, that I made from the edge of the abyss to having liver being resectable. I attach MRI to see what 12 cycles of chemo did in conjunction with the Ivermectin and other supplements and therapies"

"I started with 20+ metastases, 3 of them being almost 10cm big!"

KEY POINTS:

“My doctor said "she has only seen such a good response in the literature, but never with her own eyes." "

“My doctor said in the beginning that getting a complete response for a solid colorectal tumor with just a chemotherapy is basically impossible or very rare. However that is exactly what happened right now, or very close to it.”

“I am taking more than in the protocol of the turkey tail mushroom (4g per day) and I added Lion's mane mushroom (2g per day) as well.

I have zero side effects from 5FU or Oxaliplatin, which is also unusual, because I did have side effects from Oxaliplatin on my 3. and 4. cycle, but since I am taking the mushroom supplements, the side effects disappeared.”

“I take high dose of Turkey tail mushroom, about 5g per day and Chaga, and I think that helps me a lot to sustain my immune system.”

Can you take Ivermectin and Fenbendazole when the liver is FULL of cancer?

You can see clearly, the answer is YES!!

This is a history-making case.

I have the world's largest Ivermectin CANCER CLIENTELE, 7900+ Cancer patients from around the world!

I send my love to SLOVENIA and it's people! 🙏

I send my love to FLORIDA and the site of the FUTURE of Cancer Care!! 😃

02/01/2026

COVID-19 Vaccine Induced Turbo Cancer has been confirmed by over 100 peer reviewed studies

including an 8.4 million South Korean National Health Insurance Database study which found:

47% higher risk of cancer post AstraZeneca, J&J
20% higher risk of cancer post Pfizer, Moderna mRNA at 1 year after COVID-19 Vaccination

Only the most incompetent doctors who are 5 years behind published scientific data are still in denial, although it's probably because they were stupid enough to recommend contaminated, cancer causing injections to all of their own patients and took them themselves.

27/12/2025

MERRY CHRISTMAS!! 😃☦️

I hope you all had an amazing Christmas!

We are now helping 7800+ Cancer patients with repurposed drugs (Ivermectin, Mebendazole, Fenbendazole) including 100 children. 👏

God bless you all for your incredible support!!

24/12/2025

NEW ARTICLE: IVERMECTIN and MEBENDAZOLE Testimonial - 22 year old Canadian man with Stage 4 Esophageal Cancer (history of 2 Pfizer vaccines) achieves remission after 5 months!!

🚨 This one is a MUST READ...

STORY:
May 2025 - 22 year old Canadian man was diagnosed with Stage 4 Esophageal Adenocarcinoma with metastases to abdominal and pelvic lymph nodes (he has a history of 2 Pfizer COVID-19 mRNA Vaccines in 2021)

He had 5 sessions of radiotherapy and started chemo: FOLFOX6 with Nivolumab

In July 2025 he started:

Ivermectin 1mg/kg/day
Mebendazole 1000mg/day
CBD Oil 100mg/day

After 3 months his circulating tumor DNA went 1818 PPM to 0

After 5 months his follow-up scans were clean.

He is "Cancer Free"

KEY POINTS:

I don’t know it this was a Pfizer mRNA Vaccine induced Turbo Cancer but the suspicion in there.

I’ve talked about Turbo Cancers occurring in much younger people.

Do you know what is the average age for an Esophageal Cancer case?

69 years old.

This patient is 22 years old.

That is a 47 year shift from the average age for this cancer.

Let that sink in.

I have the world's largest Ivermectin Cancer Clientele

William Makis ONC

09/01/2026

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