17/11/2023
All the latest research on placing a weight on your back and exercising….. it’s good, until it’s not good. Welcome to reasonable ideas
Hey nerds, 😃
🙃What is the extent of the positive impact of spinal loading on intervertebral disc cells?
😄Several studies have investigated the impact of loading on intervertebral disc (IVD) cells and entire IVDs, often utilizing animal or occasionally human samples.
😃Recent review articles (references 72 and 73) offer detailed insights into the effects of loading in in vitro and external loading models.
😀Static loading of the IVD tends to be detrimental, leading to increased cell death, decreased matrix component production, and elevated catabolic markers alongside reduced anabolic markers.
😃IVD immobilization or disuse typically results in glycosaminoglycan losses in small-animal models.
😃Dynamic loading of the IVD can elicit a positive response, but the magnitude, frequency, and duration of the applied load are crucial.
😁There seems to exist a 'physiological range' of dynamic axial compressive loads that induces an anabolic response in the IVD. Beyond this range, a catabolic response is usually observed.
😃One review (reference 72) suggests this range is 0.2–0.8 MPa, with a frequency of 0.1–1 Hz and a duration of 8 hours/day.
😁Responses differ between degenerated IVDs, IVDs from older animals, or cells from such IVDs compared to young and/or healthy IVDs.
😄For instance, cells from older and/or degenerated IVDs showed a smaller increase in proteoglycan production in response to loading.
😄In conclusion, this body of literature emphasizes that the IVD adapts to loading, potentially strengthening it, but loading can also have negative (catabolic) effects.
Go read!
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3207351/ #:~:text=In%20summary%2C%20static%20compression%20loading,magnitude%2C%20frequency%20and%20duration%20dependent
If interested in more research reviews, go visit https://www.facebook.com/NerdyMPT and https://www.instagram.com/borntobenerdy/
See ya!