15/10/2025
You may think of the va**nal and endometrial microbiomes as separate ecosystems, but their proximity and shared regulation make them more like roommates sharing a wall. Both belong to the female reproductive tract microbiome continuum, yet each has its own micro-identity and immune tone.
Both are shaped by hormonal cycling, mucosal immunity, and sexual or reproductive activity. In health, Lactobacillus species dominate particularly: L. crispatus, L. jensenii, and L. gasseri, maintaining low pH and producing lactic acid, hydrogen peroxide, and bacteriocins for protection.
The va**nal microbiome is the frontline defender, dense, acidic (pH 3.8–4.5), and highly responsive to hormones, systemic health, and lifestyle.
The endometrial microbiome, though connected via the cervix, is a quieter, low-biomass environment. It’s less acidic (pH 6–7) and detectable only with ultra-sensitive tools such as qPCR, 16S rRNA, or metagenomic sequencing. It’s typically Lactobacillus-dominant but can include Bifidobacterium, Gardnerella, Cutibacterium, and, in imbalance, Streptococcus, Staphylococcus, Enterococcus, and anaerobes.
A Lactobacillus-rich endometrium supports implantation and pregnancy. Dysbiosis, however, can trigger inflammation, chronic endometritis, or fertility challenges.
Because of its low biomass, endometrial microbiome sampling demands care, contamination from the va**na is a known confounder. Some clinics use sterile catheter-based sampling; others assess menstrual blood, ideally paired with va**nal testing for context.
Supporting both microbiomes means considering their shared influences, the gut, hormones, immune tone, and mucosal resilience.
Naturopathic and holistic care can individualise this support, complementing or standing alongside standard interventions.
Ultimately, we’re not just “balancing bugs”, we’re restoring harmony across interconnected eco-niches.
Have you heard of the endometrial microbiome before?