Translational Research Institute

Translational Research Institute Unique, Australian-first initiative of ‘bench to bedside’ medical research, combining clinical &

The Translational Research Institute (TRI) is a unique, Australian-first initiative of ‘bench to bedside’ medical research. TRI combines clinical and translational research to advance progress from laboratory discovery to application in the community. The concept of a major research institute on this site arose from the thinking of notable Queensland clinicians including Professor Bryan Emmerson and Dr John Golledge, and the vision was conceived and brought to fruition by the clinicians and scientists of the four institutions who were its founding partners; The University of Queensland, Queensland University of Technology, Mater Medical Research Institute and Queensland Health. Translational Research – Our Work

Translational Research aims to convert scientific innovations into health gains. It involves a multidisciplinary approach, early involvement with a commercial partner and a focus on positive outcomes for patients, the community and world health. The work conducted at TRI is translational research, a research process which involves teams of patients, clinicians and researchers working together to solve health challenges faster. The work is driven by the needs of patients, a question formed by a clinician and a solution sought by a scientist. While traditionally, clinicians and researchers worked separately, this improved method ensures patient needs are priority and that teams share knowledge which multiplies with every collaboration. These teams also create a feedback loop which is essential to the translational pathway. With the clinician and scientist working side by side with the patient, results are obvious immediately rather than via long reports which take time to read and interpret. Several translational research projects are underway at TRI, including the Gardasil HPV Vaccine, Spectroscopy for high risk breast cancer, and Theranostic Development for Prostate Cancer.

08/07/2025

“The future of precision medicine comes from taking learnings at the bench to the patient bedside and back to the bench again. This process is at the heart of translating research.”

TRI CEO Professor Maher Gandhi shares his thoughts on the meaning of translational research - and provides insights into our vision for exceptional science, healthier lives.

Find out more: https://www.tri.edu.au/what-is-translational-research

20/05/2025

It's International Clinical Trials Day.

Clinical researchers move innovations from scientific discovery to the medicinal, surgical and preventative advances of tomorrow. This is also known as research translation.

TRI very much operates in this space, combining facilities, expertise and collaborations to take research into clinical trials - and involve the people who may benefit.

One of TRI's clinical trial facilities is at Queensland Children’s Hospital campus, providing a welcoming environment for research volunteers who participate in leading-edge research.

Read more: https://www.tri.edu.au/facilities/tric

Today, on Anzac Day, we pause to honour the courage and sacrifice of the Australian and New Zealand servicemen and women...
24/04/2025

Today, on Anzac Day, we pause to honour the courage and sacrifice of the Australian and New Zealand servicemen and women who have served our countries in times of war, conflict and peacekeeping. Lest we forget.

Congratulations, Associate Professor Lucy Burr, starting her new role today as Director of Clinical Research at Mater Re...
30/03/2025

Congratulations, Associate Professor Lucy Burr, starting her new role today as Director of Clinical Research at Mater Research.

A/Prof Burr is a respiratory physician and clinician-researcher leading the Chronic and Integrated Care Program and the Respiratory and Infectious Diseases Research Group.

She will be dividing her time between Mater's South Brisbane campus and TRI.

Read more: https://www.materresearch.org.au/news-publications/news/2025/march/mater-research-appoints-new-director-of-clinical-research

Congratulations, TRI-based Associate Professor Arutha Kulasinghe from The University of Queensland  , winner of a presti...
27/03/2025

Congratulations, TRI-based Associate Professor Arutha Kulasinghe from The University of Queensland , winner of a prestigious national award.

Associate Professor Kulasinghe won the National Health and Medical Research Council - NHMRC Science to Art Award for his digital image of a human skin cancer in the head and neck region. Skin cells are in bright red, with tumour pockets in dull red surrounded by yellow.

Another UQ winner at the awards evening was Professor Glenn King, receiving the Peter Doherty Investigator Grant Award (Leadership) for his research into translating peptides from spider venom into human therapeutics.

Professor King is the co-founder of TRI-based Infensa Bioscience, which is using the peptides to develop therapeutics to reduce death and disease from heart disease and stroke.

Read more: https://www.uq.edu.au/news/article/2025/03/art-meets-science-uq-researchers-win-nhmrc-awards

An increase in new cases of type 1 diabetes (T1D) was reported around the world during the COVID-19 pandemic – and resea...
26/03/2025

An increase in new cases of type 1 diabetes (T1D) was reported around the world during the COVID-19 pandemic – and researchers have been trying to determine if there is a link.

Until now.

TRI-based Professor Emma Hamilton-Williams from The University of Queensland is part of a research study that has determined there is no link.

The ENDIA study involved researchers from five Australian states and 1473 children at risk of T1D from around the country.

Central to the research was a study of the connection between COVID-19 and islet autoimmunity, an early stage of T1D when specific cells from the pancreas which produce insulin are mistakenly attacked by the immune system.

The research was published in JAMA Pediatrics, finding the rate of islet autoimmunity among study participants was the same during and after the pandemic, with suggestions other environmental factors may be involved in T1D development, such as each person’s specific gut health, nutrition, other viruses or exposure to pollution.

Read the research publication: https://jamanetwork.com/journals/jamapediatrics/fullarticle/2830778

High school students from across South East Queensland have tapped into a world of science at TRI during the Labs Unlock...
25/03/2025

High school students from across South East Queensland have tapped into a world of science at TRI during the Labs Unlocked Program.

TRI-based program SPARQ-ed welcomed the students as part of the World Science Festival Brisbane.

They carried out experiments, learned techniques used to study cancer and met TRI-based cancer biologist Debottam Sinha from The University of Queensland .



More about SPARQ-ed: https://www.tri.edu.au/resources/sparq-ed

Polyploidy is a common condition in plants, fish, and amphibians, where cells have more than two complete sets of chromo...
25/03/2025

Polyploidy is a common condition in plants, fish, and amphibians, where cells have more than two complete sets of chromosomes.

It can also be a common outcome of chemotherapies, as well as the result of a class of medicines called Aurora B kinase inhibitors (AURKB) – being studied for a range of cancers, but not yet approved for clinical use.

TRI-based Professor Brian Gabrielli from Mater Research has found that AURKB treatment results in hyper-polyploidy in certain cells that then become unable to form tumours.

The cells have also lost the potential to proliferate – that is, to grow and divide, essential for tissue repair, development and maintenance.

Professor Gabrielli has been studying cell mechanisms that determine their ability to proliferate and published the results in Cell Death and Disease.

“The findings demonstrate that higher ploidy states are incompatible with long-term proliferative potential in tumour cells,” he says.

Read the publication: https://www.nature.com/articles/s41419-024-07329-7

It's World Tuberculosis Day.It's a sobering fact: as Covid deaths decline, TB has again become the world’s deadliest inf...
24/03/2025

It's World Tuberculosis Day.

It's a sobering fact: as Covid deaths decline, TB has again become the world’s deadliest infectious disease.

Scientists, health professionals and patients have come together at TRI today to mark the day and discuss disease impacts, research and the future.

Thank you to all who contributed, as organisers, presenters and participants. Thank you:

- Dr Geoff Eather and Alexa Hemens Alford (pictured, right) from Queensland Health
- Professor Antje Blumenthal (centre) and Professor Kiarash Khosrotehrani from The University of Queensland
- Rahul Kumar (left)

Read more: https://www.tri.edu.au/resource/tb-most-deadly

TRI-based Associate Professor Nathalie Bock from QUT (Queensland University of Technology) is developing models of human...
21/03/2025

TRI-based Associate Professor Nathalie Bock from QUT (Queensland University of Technology) is developing models of human bone conditions in the laboratory using tissue engineering technologies.

The models mimic aspects of the human bone microenvironment by using biomaterials with patient cells. The goal is to better understand how the bone organ functions and address incurable and painful disease conditions such as bone metastatic cancers.

A/Prof Bock and her team are investigating how hydrogel biomaterials and their culture can coordinate bone-forming cells and their matrix to produce specific types of bone tissues.

This is called bone tissue engineering and it aids researchers in understanding how bone tissue can best be guided to form or repair – for now in the laboratory, but ultimately in people with trauma, fractures or bone diseases.

The team’s work been featured on the front cover of Advanced Healthcare Materials, showing the importance of preculture conditions to enhance the process of bone matrix formation in the models, a critical condition to the accuracy of the models formed.

Read more: https://advanced.onlinelibrary.wiley.com/doi/abs/10.1002/adhm.202570008

Medical research isn't just scientists in the laboratory looking at cells and talking to their colleagues.Among the impo...
21/03/2025

Medical research isn't just scientists in the laboratory looking at cells and talking to their colleagues.

Among the important voices in research are those of patients, to ensure impact, relevance and confidence.

Queensland's Merran Williams is an ovarian cancer survivor and a registered nurse who shares her personal experiences - and is part of the TRI-UQ webinar Introduction to Consumer Involvement in Research from 11.30am on Wednesday 26 March.

The webinar will explore the value and contribution that consumer and community involvement can have in research, how to recruit and how to support them.

Merran also contributes to research with Professor Monika Janda and Professor Andreas Obermair from The University of Queensland (pictured).

Read more and register: https://www.surveymonkey.com/r/IntroCCIWebinar

The countdown is on to World Tuberculosis Day.While 79 million lives have been saved since 2000 by global efforts to end...
19/03/2025

The countdown is on to World Tuberculosis Day.

While 79 million lives have been saved since 2000 by global efforts to end tuberculosis (TB), it remains the world's deadliest infectious disease.

TRI-based Professor Antje Blumenthal from The University of Queensland combines expertise in immunology and microbiology to lead research that aims to continue the fight against TB.

Her team’s research focuses on molecular mechanisms that control how the immune system responds to the infection with TB bacteria and how we can improve our ability to treat TB.

Professor Blumenthal will present at a special World TB Day Symposium at TRI from 12:00 on Monday 24 March.

Register here: https://www.surveymonkey.com/r/MM9DMV3

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