14/03/2026
I was chatting to a patient the other day about anxiety, sleep, and that feeling of being constantly on edge even when her life wasn’t actually that stressful…well that’s what she said, and we ended up talking about histamine… in the brain.
Most people have no idea that histamine is actually a neurotransmitter, and one that keeps the brain alert and switched on. Which is great when you need to focus, react or think quickly… but not so great when your nervous system already struggles to slow down.
What’s really interesting is that histamine isn’t just about what you eat, it’s also about how your body breaks it down and even what time of day it is.
Histamine follows a circadian rhythm, meaning it naturally changes across the day and night and in some people it can spike overnight or in the early hours of the morning. This is one of the reasons some women wake around 2 or 3am with a racing mind, hot, restless, or feeling like their body has decided it’s time to be wide awake for absolutely no reason.
I see this a lot in women and AFAB folk who are high functioning on the outside but internally feel wired, sensitive, reactive, and exhausted all at the same time. They often also get headaches, flushing, gut issues, skin flare ups, or feel worse before their period or during perimenopause. That’s not random either btw, because oestrogen and histamine actually stimulate each other, which means hormonal changes can make the nervous system feel even more on edge.
The other part people don’t realise is that histamine balance depends on nutrients. Your body needs things like vitamin B6, zinc, copper, magnesium, vitamin C, healthy gut bacteria and good liver function to clear histamine properly. So sometimes it’s not that your nervous system is overreacting… it’s that the chemistry underneath it is a bit overstimulated.
This is why I love looking at the brain and nervous system from a naturopathic perspective because it’s never just about stress, it’s about neurotransmitters, hormones, gut health, nutrients, sleep and how all of those things talk to each other.
Honestly, the more I learn about the brain the more everything starts to make sense.
Tara 🧠💛 x