06/05/2026
In case you haven’t been following my stories, I recently started low-dose off-label tirzepatide (Mounjaro) to see if it could help manage my MCAS (especially hormonal auras/silent migraines) and pain and inflammation (adenomyosis).
I’m very grateful to have a supportive GP who was open to giving this a go after I mentioned the research coming out on low-dose off-label use for endometriosis. He agreed that he’d been seeing people report improvements to pain and inflammation so he was open to giving it a go.
Within the first DAY, the brain fog lifted. Blown away.
Most notably, my sleep is the deepest restorative sleep I’ve had since pre-pregnancy.
This decision wasn’t made lightly. I’ve been closely following this space the last year and also seeing more of my own on them. The turning point for me was seeing the emerging evidence on GLP-1 in endometriosis and MCAS.
GLP-1s are often spoken about in the space of metabolic health - and rightly so. They’re life changing and life SAVING in this area.
But further to that, we’re realising that GLP-1 receptors exist all throughout the body including on mast cells. People with endometriosis also appear to have differences in their GLP-1 receptors.
Sadly, there’s a lot of fear, myths and misconceptions about these medications and as a result, people are too afraid to take them (or talk about them publicly) when it could be totally turning their life around.
Unfortunately they are also not affordable for many and this is a big gaping hole right now. With that said I’ve spoken to many who’ve said they now save money in other areas such as other medications or supplements they no longer need, alcohol they no longer crave and excess takeaway and food they didn’t need.
Make no mistake, there are still side effects for many - but mostly temporarily in the beginning. In rare but still important cases, the side effects may be more severe. But this is no different to every other medication, herb, supplement, surgery or intervention that comes with risks.
The most important part is having the right support around its use.
Would love to hear your experience on them.