18/04/2026
Lichen sclerosus (LS) is often approached as a localised skin conditionn with some discussion of autoimmune links.
Emerging research suggests broader shifts in physiology may be involved.
This includes some very relevant microbiomes.
Recent data in peri- and postmenopausal women shows changes across:
• The gut microbiome
• The vaginal microbiome
• The vulval skin ecosystem
Indicating that skin and immune interact through microbes influencing immune signalling, hormone metabolism, and barrier function.
In menopause, when estrogen shifts, these ecosystems can become less stable. For some, this contributes to inflammation, tissue changes, and symptom expression. We see peaks of LS diagnosis in this life stage because of the impacts of declining estrogen.
LS is complex and often responds best to an integrative approach. One that recognises that:
local symptoms may reflect wider system changes in addition to topical steroid therapies.
If you want to explore this further, I’ve written about a paper exploring these ecosystems in LS over on the Intimate Ecology blog.
Link in bio.
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