10/12/2025
Endotoxin (LPS) causes damage to the gut and, importantly, inflammatory changes throughout the body.
Endotoxemia is now seen as a key driver in a range of common chronic diseases, such as Alzheimer's disease, atherosclerosis, depression, metabolic syndrome, obesity, and even osteoporosis. Bacteria that contain and release endotoxin include E. coli, Klebsiella, Enterobacter, Salmonella, and Bacteroides & Alistipes - although the LPS from the latter 2 genera is comparatively less potent. Some people have considerably more of these bacteria and endotoxin in the gut than others.
Fortunately, certain foods can help increase IAP levels in the gut, such as black pepper, hot peppers, ginger, turmeric, and St. Mary's Thistle.
On the other hand, a Western-type diet reduces IAP and increases endotoxin exposure.
