13/04/2020
To protect yourself against Acute Respiratory Infections, Vitamin D, as showing in this research article, is essential!
Go get some Sun!! Even if it's in your front or back yard.
For The full article go to:
https://www.bmj.com/content/356/bmj.i6583?fbclid=IwAR1UDnekfZXI2XAquXprbIIhJJgRM-BiU2QfJFrABOHWVC3ivTEoCdbyA8M
Research
Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and meta-analysis of individual participant data.
BMJ 2017; 356 doi: https://doi.org/10.1136/bmj.i6583 (Published 15 February 2017)Cite this as: BMJ 2017;356:i6583
Adrian R Martineau, professor of respiratory infection and immunity1 2, David A Jolliffe, postdoctoral research fellow1, Richard L Hooper, reader in medical statistics1, Lauren Greenberg, medical statistician1, John F Aloia, professor of medicine3, Peter Bergman, associate professor4, Gal Dubnov-Raz, consultant paediatrician5, Susanna Esposito, professor of paediatrics6, Davaasambuu Ganmaa, assistant professor7, Adit A Ginde, professor of emergency medicine8, Emma C Goodall, assistant professor9, Cameron C Grant, associate professor10, Christopher J Griffiths, professor of primary care1 2 11, Wim Janssens, professor of pneumonology12, Ilkka Laaksi, chief administrative medical officer13, Semira Manaseki-Holland, senior clinical lecturer14, David Mauger, professor of public health sciences and statistics15, David R Murdoch, professor of pathology16, Rachel Neale, associate professor17, Judy R Rees, assistant professor18, Steve Simpson Jr, postdoctoral research fellow19, Iwona Stelmach, professor of paediatric allergy20, Geeta Trilok Kumar, associate professor21, Mitsuyoshi Urashima, professor of molecular epidemiology22, Carlos A Camargo Jr, professor of emergency medicine, medicine, and epidemiology23
Correspondence to: A R Martineau a.martineau@qmul.ac.uk
Accepted 1 December 2016
Abstract;
Objectives: To assess the overall effect of vitamin D supplementation on risk of acute respiratory tract infection, and to identify factors modifying this effect.
Design Systematic review and meta-analysis of individual participant data (IPD) from randomised controlled trials.
Data sources: Medline, Embase, the Cochrane Central Register of Controlled Trials, Web of Science, ClinicalTrials.gov, and the International Standard Randomised Controlled Trials Number registry from inception to December 2015.
Eligibility criteria for study selection: Randomised, double blind, placebo controlled trials of supplementation with vitamin D3 or vitamin D2 of any duration were eligible for inclusion if they had been approved by a research ethics committee and if data on incidence of acute respiratory tract infection were collected prospectively and prespecified as an efficacy outcome.
Results: 25 eligible randomised controlled trials (total 11 321 participants, aged 0 to 95 years) were identified. IPD were obtained for 10 933 (96.6%) participants. Vitamin D supplementation reduced the risk of acute respiratory tract infection among all participants (adjusted odds ratio 0.88, 95% confidence interval 0.81 to 0.96; P for heterogeneity