10/10/2025
doiRhodiola rosea and the Blood Brain Barrier
Remember I did a post a while ago about the blood brain barrier and how the 'tight junctions' can become compromised, letting unwanted substances into the astrocytes.? Here is the rest of the information.
Also known as rosenroot, golden root and orpin rose, Rhodiola has been used throughout North America, China and Europe in Traditional medicines. There are about 96 species, all growing in alpine regions in limestone or granite soils. Five species are used medicinally and are being studied in relation to Alzeihmer's, Parkinson's, cerebrovascular diseases, diabetes and cardiovascular diseases. Components can vary between species and the method of extraction. The main component that seems to protect brain tissue is called salidroside. This compound has been shown to reduce plaque deposits in brain tissue, protect neurons from oxidative stress and increase the permeability of the blood brain barrier to dopamine precursors. This in turn reduces inflammation in brain tissue. Salidroside may also facilitate the production and proliferation of dopamine producing cells. It also has an antioxidant effect on brain tissue and prevents neural injury associated with memory loss.
Most of this information comes from rat and mice studies, but it is hard to study in humans. Our knowledge on brain biochemistry and pathways has increased so much in the last decade and will only increase more with more funds going into research into MND, Alzheimer's (and others), brain injury and stroke and it's exciting that many scientists are also researching plant components that may be helpful.
Rosenroot: Potential Applications in Aging Related Diseases
doi: 10.14336/AD.2018.0511
Other articles you may want to read
Pe*******on of Therapeutic Drugs Across Blood Brain Barrier
doi.org/ag.1016/j.xcrm.2024.101760
Drug Transport Across the Blood Brain Barrier
doi.10.1038/jcbfm.2017126