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Reality Partners Fellowship site for Christians.and other people wishing to be healthy physically, mentally,emotionally and spiritually

Reality Partners is the logical first choice site for surrounding areas of Newcastle, NSW-- because of the firm’s vast research and our professional team who provide an excellent health service.

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23/02/2023

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Join the community of thousands who have found freedom from depression and anxiety. The program is well researched and scientifically based, encompassing the whole person.

27/08/2022

Progesterone and Men

It is important to understand, that progesterone is not a feminising hormone. Progesterone is also produced by the te**es; in men and has significant benefits. Not least, it keeps oestrogen in check!

* It inhibits 5-alpha reductase, which converts testosterone into the more aggressive DHT (7)

* It inhibits noradrenaline in men; this stress hormone can limit libido.

* Progesterone can improve s***m counts - oestrogen and xenoestrogen, reduce them (8)

* Progesterone is involved in a good night's sleep

* Progesterone is involved in bone mass for men, not just women

* Progesterone can reduce high blood pressure in men too.

26/08/2022

IP-6 and Prostate cancer

In 2010, Dr. Mallikarjuna Gu at the University of Colorado Cancer Center found that inositol hexaphosphate (IP-6, or phytic acid), a naturally occurring compound found in high fibre foods and supplements could block P13K-Akt, a core cancer pathway, both in Petri dishes and in animals with prostate cancer. Gu and his team had found a major target to restrict cancer progression (1).

Leader of the Cancer Center’s program on treatment and prevention, Dr. Rajesh Agarwal said that inositol, a B vitamin, which is found in high fibre foods such as nuts, seeds, grains, lentils and other legumes, may explain why those people who eat high fibre diets develop less cancers. IP-6 is not exactly the same as inositol, although it too is naturally occurring in the same foods; it is an inositol molecule with 6 phosphate groups attached.

Indeed, some of the best results with arresting cancer progression occurred when the research team used both inositol and IP-6 together. One of the best natural sources of IP-6 is found in rice-bran extract.

This was not the first time IP-6 had shown benefit with prostate cancer. Agarwal and Rana Singh in the same centre had shown that oral supplementation of IP-6 inhibited cancer growth, progression and signaling in mice models in a pilot study. IP-6 was also shown to target angiogenesis - blood supply to tumours (6).

08/04/2022

Disruption of nocturnal MLT secretion in night shift workers has been associated with modestly increased risk for breast and other cancer types.5-8 A 2005 meta-analysis of 13 observational studies found significantly increased breast cancer incidence among female airline cabin crew (standardized incidence ratio = 1.44; 95% confidence interval [CI] = 1.26-1.65) and in female night workers (relative risk [RR] = 1.51; 95% CI = 1.36-1.68).9 More recently, the International Agency for Research on Cancer reclassified “shiftwork that involves circadian disruption”10 from a possible to a probable (group 2A) human carcinogen, in recognition of this relationship.
On the strength of these findings, Denmark has become the first country to declare breast cancer an “occupational disease.”11 Danish women with breast cancer have begun receiving compensation if, without any other risk factors, they had been working at least 1 night shift a week for the past 20 years.10,11 This development highlights MLT as highly relevant not only within the field of medical oncology but also in the area of public health.
As a possible explanation of the mechanism by which MLT may affect breast cancer risk, the melatonin hypothesis suggests that lowered levels of MLT secretion at night may lead to increased estrogen levels and increased turnover of breast epithelial stem cells, with subsequent increased risk of malignant transformation.12 MLT appears to impact estrogen metabolism through selective estrogen receptor modulator (SERM) and selective estrogen enzyme modulator (SEEM) activity.13
In addition to hormonal effects, MLT is thought to possess immunopotentiating and oncostatic effects by increasing the activity of T and B lymphocytes, monocytes, natural killer cells, and immunoactive cytokines (IFN [interferon]-γ, IL [interleukin]-2, IL-6, and IL-12) as well as promoting apoptosis and inhibiting angiogenesis.2,3 Human intervention trials of MLT for the prevention of cancer are notably lacking; however, studies of MLT for active treatment of cancer have been promising.
In 2005, we published a meta-analysis reviewing 10 human trials of MLT in solid tumor cancers and reported findings of mortality at 1 year (RR = 0.66; 95% CI = 0.59-0.73).4 Many of these trials were conducted in conjunction with chemotherapeutic agents, including tamoxifen, cisplatin, etoposide, IL-2, and radiotherapy. Although the pooled analysis showed benefit on survival, the impacts of MLT on chemotherapy-induced side effects such as alopecia, asthenia, and thrombocytopenia were not reviewed. This systematic review and meta-analysis updates our 2005 meta-analysis. In addition to updating pooled survival statistics, this review holds special relevance to the use of MLT alongside chemotherapy: it assesses the impact of MLT with chemotherapy on therapeutic efficacy, measured as patient survival, and assesses the tolerability of chemotherapy, measured as the extent of chemotherapy-associated toxicities.

03/03/2022

Interleukin-6 (IL-6) is secreted in great quantity in prostatic tumoral glandular tissue with a significant higher rate in hormono-refractory phase. Importance of IL-6 dependent mechanism in prostate cancer progression is well argued. IL-6 seems to be implicated in androgen receptor activation in lack of steroid ligand, apoptosis decrease and increase of invasive capacity and angiogenesis via three major signaling pathways: MAPK, STAT3 and PI3K-Akt. As AR is a key factor of prostate cancer progression, IL-6 implication in this activation underlines IL-6 importance in prostate cancer. IL-6 also induces neuroendocrine differentiation. This phenomenon received a detailed attention because it would take part in pathogenicity and progression of prostate cancer. Although complementary studies seem necessary, taking into account its strong implication in prostate cancer progression, IL-6 seems to be a new potential therapeutic target of prostate cancer.

23/02/2022

turmeric. Anti-inflammatory effects of turmeric have been known for centuries and extensive studies over the last two to three decades revealed that curcumin is a key component in the anti-inflammatory effects of turmeric. Chronic inflammation is involved in the various pathologic states and curcumin demonstrated therapeutic effects in different inflammation-related diseases in various in vivo, in vitro and human based studies through regulation of different signaling molecules including transcription factors, chemokines, cytokines, tumor suppressor genes, adhesion molecules and microRNAs. Interleukin-6 (IL-6) plays important roles in various events during inflammation including regulation of antibody (and autoantibody) production, activation of T cells, differentiation of B cells, increased production of acute-phase proteins, hematopoiesis and angiogenesis, vascular permeability, and osteoclast differentiation. IL-6 is also involved in pathogenesis of different inflammatory diseases. There are numerous studies demonstrating association of down-regulation of IL-6 and/or inhibition of IL-6 signaling with therapeutic effects of curcumin suggesting a role for modulation of IL-6 in anti-inflammatory effects of curcumin. Moreover, curcumin can be considered as potential therapy against IL-6 involved pathologic stats. In this narrative review, the in vitro, experimental and clinical studies that report association of IL-6 inhibition and therapeutic effects of curcumin are discussed.

02/02/2022

Excess body weight is associated not only with an increased risk of type 2 diabetes and cardiovascular disease (CVD) but also with various types of malignancies. Adiponectin, the most abundant protein secreted by adipose tissue, exhibits insulin-sensitizing, antiinflammatory, antiatherogenic, proapoptotic, and antiproliferative properties. Circulating adiponectin levels, which are determined predominantly by genetic factors, diet, physical activity, and abdominal adiposity, are decreased in patients with diabetes, CVD, and several obesity-associated cancers. Also, adiponectin levels are inversely associated with the risk of developing diabetes, CVD, and several malignancies later in life. Many cancer cell lines express adiponectin receptors, and adiponectin in vitro limits cell proliferation and induces apoptosis. Recent in vitro studies demonstrate the antiangiogenic and tumor growth-limiting properties of adiponectin. Studies in both animals and humans have investigated adiponectin and adiponectin receptor regulation and expression in several cancers. Current evidence supports a role of adiponectin as a novel risk factor and potential diagnostic and prognostic biomarker in cancer. In addition, either adiponectin per se or medications that increase adiponectin levels or up-regulate signaling pathways downstream of adiponectin may prove to be useful anticancer agents. This review presents the role of adiponectin in carcinogenesis and cancer progression and examines the pathophysiological mechanisms that underlie the association between adiponectin and malignancy in the context of a dysfunctional adipose tissue in obesity. Understanding of these mechanisms may be important for the development of preventive and therapeutic strategies against obesity-associated malignancies.

18/01/2022

Estrogen is involved in number of cancers [80]. Honey modulates estrogen by its antagonistic action. It may be useful in estrogen-dependent cancers such as breasts and endometrial cancers [17]. Estrogen receptors tie to estrogens to dimerize and then translocate into the nuclei. These complexes then bind to the specific DNA base sequences called estrogen-response elements (EREs) resulting in transcription and translation of the estrogenic effect in the targeted tissue [80]. This signaling cascade induced by estrogens may be modulated at any stage [80]. Honeys from various floral sources are reported to mediate estrogenic effects via the modulation of estrogen receptor activity [17, 81]. This effect is attributed to its phenolic content [17]. Greek honey extracts exert estrogen agonistic effect at high concentrations (20–100 lg/mL) and antagonistic effect at low concentrations (0.2–5 μg/mL) [17].

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9. Conclusion
Evidence is growing that honey may have the potential to be anticancer agent through several mechanisms (Figure 3). Though the full mechanism is yet to be fully understood, studies have shown that honey has anticancer effect through its interference with multiple cell-signaling pathways, such as inducing apoptosis, antiproliferative, anti-inflammatory, and antimutagenic pathways. Honey modulates the body immune system. There are still many unanswered questions; why sugar is carcinogenic, while honey which is basically sugar has anticarcinogenic properties. Honey of different floral sources may give different effects. More research is needed to improve our understanding of the positive effect of honey and cancer. What is seen in cell cultures or animal experimentations may not apply to humans. Prospective randomized controlled clinical trials are needed to validate the authenticity of honey either alone or as adjuvant therapy.

10/11/2021

Elevated circulating insulin levels are frequently observed in the setting of obesity and early type 2 diabetes, as a result of insensitivity of metabolic tissues to the effects of insulin. Higher levels of circulating insulin have been associated with increased cancer risk and progression in epidemiology studies. Elevated circulating insulin is believed to be a major factor linking obesity, diabetes and cancer. With the development of targeted cancer therapies, insulin signalling has emerged as a mechanism of therapeutic resistance. Although metabolic tissues become insensitive to insulin in the setting of obesity, a number of mechanisms allow cancer cells to maintain their ability to respond to insulin. Significant progress has been made in the past decade in understanding the insulin receptor and its signalling pathways in cancer, and a number of lessons have been learnt from therapeutic failures. These discoveries have led to numerous clinical trials that have aimed to reduce the levels of circulating insulin and to abrogate insulin signalling in cancer cells. With the rising prevalence of obesity and diabetes worldwide, and the realization that hyperinsulinaemia may contribute to therapeutic failures, it is essential to understand how insulin and insulin receptor signalling promote cancer progression.

28/09/2021

Progesterone Treatment of Prostate Cancer has become a popular search that lots of people do when talking about prostate cancer. Do you know that progesterone -a reproductive hormones found in women- can be used in the treatment of prostate cancer? This is a fact and this can be applied as “Hormonal Therapy”. Researches have discovered that excess testosterone produced by the testicles can be converted into Dihydrotesteosterone or DHT. If this happens, cancer cells are developed in the prostate to counter or inhibit the actions of DHT in the body. Progesterone treatment is applied to help with this.

Treatment of prostate cancer with progesterone can be referred to as Androgen Deprivation Therapy or ADT. The aim of the treatment is to restrict or inhibit testosterone in the body. This procedure has been applied effectively over the years and many doctors or physicians recommend it for various stages of prostate cancer.

11/08/2021

The importance of maintaining optimal vitamin D levels here are a few more of the reported benefits of vitamin D supplementation for people with kidney disease:

Serum parathyroid hormone levels decrease
Reduced proteinuria
Improvement in endothelial cardiovascular markers
Reduced inflammatory markers and reduced oxidative stress
Better control of blood sugar levels and diabetes
Lower blood pressure
Increased red blood cell production and iron levels
Decreased need for erythropoiesis stimulating agents
Slower progression of kidney disease and improved survival
Please take D3 if you have low blood levels.

11/08/2021
11/08/2021

The initiator couple on this site, Who are they?

09/07/2021

3. calcium d-glucarate Supplementation

Calcium D-glucarate is a calcium salt of glucaric acid, which is found naturally in fruits and vegetables. Oranges, grapefruits, apples and cruciferous vegetables have the highest amounts of glucaric acid. When it comes to getting higher doses of glucaric acid, supplementation is usually your best bet.

Calcium D-glucarate is a helpful tool to reduce circulating estrogens because it inhibits beta-glucuronidase. This supplement can be helpful if your stool test confirms that you have high beta-glucuronidase levels.

While this supplement is helpful, it does not correct the gut microbial imbalances that cause high beta-glucuronidase. So be sure you’re looking at the bacterial balance as well. But it’s very effective in reducing symptoms of estrogen dominance while you are addressing your overall gut health.

02/03/2021

Pneumonia patients are more likely to suffer from depression and cognitive impairment, according to research. The study uncovered that pneumonia patients are twice as likely to develop cognitive impairment, while hospitalized older patients are at a higher risk for other health complications like a heart attack and stroke.

Senior author Dr. Theodore J. Iwashyna said, “Pneumonia is clearly not only an acute life-threatening event, but also a profoundly life-altering event. The potentially substantial chronic care needs and diminished quality of life for survivors are comparable to the effects of heart disease, yet we invest far fewer resources to pneumonia prevention.”

The researchers found that study subjects who were hospitalized for pneumonia were more likely to develop cognitive impairment – and the impact was so severe that it led to disability and nursing home admissions.

Lead author Dr. Dimitry S. Davydow added, “Even non-critical pneumonia hospitalization can lead to long-term adverse outcomes at a magnitude much greater than we previously thought. Pneumonia prevention and interventions are crucial, given the costly and detrimental consequences for patients.”

07/12/2020

7 Effects your vibration frequency from the point of view of quantum physics.
Vibration in quantum 7 things that affect physics means everything is energy. We are vibrant beings on certain frequencies. Every vibration is equivalent to a feeling and in the world "Vibrational", there are only two species of vibrations, positive and negative. Any feeling makes you broadcast a vibration that can be positive or negative.
**1ST - * thoughts ***
Every thought emits a frequency to the universe and this frequency goes back to origin, so in the case, if you have negative thoughts, discouragement, sadness, anger, fear, all this comes back to you. This is why it is so important that you take care of the quality of your thoughts and learn how to cultivate more positive thoughts.
**2TH - * the companies ***
The people around you directly influence your vibration frequency. If you surround yourself with happy, positive and determined people, you will also enter this vibration. Now, if you surround yourself with people complaining, gossiping and pessimist, be careful! Indeed, they can reduce your frequency and therefore prevent you from using the law of attraction in your favor.
**3TH - * the music ***
Music is very powerful. If you only listen to music that talks about death, betrayal, sadness, abandonment, all this will interfere with what you are feeling. Pay attention to the lyrics of the music you listen to, it could reduce your vibration frequency. And Remember: you attract exactly what you feel in your life.
**4TH - * the things you look at ***
When you look at programs that deal with misfortunes, dead, betrayals, etc. Your brain accepts this as a reality and releases a whole chemistry into your body, which affects your vibration frequency. Look at things that do you feel good and helps you vibrate at a higher frequency.
**5TH - * the atmosphere ***
Whether it's at home or at work, if you spend a lot of time in a messy and dirty environment, it will also affect your vibration frequency. Improve what surrounds you, organize and clean your environment. Show the universe that you are fit to receive much more. Take care of what you already have!
**6TH - * THE WORD ***
If you claim or speak wrong about things and people, it affects your vibration frequency. To keep your frequency high, it is essential to eliminate the habit of complaining and bad talking about others. So avoid drama and bullying. Assume your responsibility for the choices of your life!
**7TH - * GRATITUDE ***
Gratitude positively affects your vibration frequency. This is a habit you should integrate now into your life. Start to thank for everything, for the good things and what you consider to be bad, thank you for all the experiences you've experienced. Gratitude opens the door for good things to happen positively in your life.

02/05/2020

PROGESTERONE is thought of as a female hormone, but it actually protects both men and women from excess estrogen. Men need progesterone in their bodies, too, only in smaller
quantities than women. The estrogens estradiol and estrone are the feminizing hormones in men, and it is progesterone that is the natural antagonist to them. Excessive estrogen levels in men Natural Prostate Cure, over fifty cause cancer, breast growth, obesity, and other health problems, but progesterone can help inhibit estrogens.
Nature has given progesterone to both men and women in order to balance and offset the strong effects of estrogen. Men, of course, have naturally lower levels of progesterone than women, so they need less supplementation. Be careful not to confuse real, natural progesterone with progestins (synthetic analogs) like Provera® that have serious side effects. Progestins do not have the advantages of natural progesterone. Men have specific progesterone receptors on
their prostates, so clearly this requires progesterone. Yet, urologists and endocrinologists are blind to such well-established scientific facts. This was demonstrated almost 40 years ago at Flinders Medical Center in Australia (Journal of Steroid Biochemistry v 12, 1980). The doctors
recommended progesterone therapy for prostate disease. In the book Progesterone and Progestins (Raven Press l983), the doctors at Service de Medicale in Paris noted that
progesterone was vital for proper prostate health. Progesterone protects men from both estrogen
dominance and overactivity of 5-alpha reductase. Your prostate needs progesterone to be
healthy.
Let’s quickly discuss the research that shows progesterone opposes and balances excess estrogen, and is a powerful 5-alpha-reductase inhibitor. Progesterone helps prevent the
conversion of beneficial testosterone into dihydrotestosterone (DHT). High levels of DHT are one cause of prostate disease. Your prostate will accept DHT instead of real testosterone if your levels are low. Men over fifty only have about half the testosterone they should. Moreover, they
also generally have very high levels of both estradiol and estrone. The best study on progesterone was conducted over forty years ago at the Faculty of
Medicine in Paris (Journal of Clinical Endocrinology and Metabolism v 38, 1974). Men were Natural Prostate Cure, for typsetting Page 88 given real transdermal progesterone (groundbreaking at the time), which dramatically inhibited
the conversion of testosterone into DHT. The researchers recommended progesterone as a standard therapy for men with prostate disease. This is an important and powerful study, but modern day urologists have simply ignored it. There are many, many animal and cell studies on the benefits of progesterone for prostate disease, but almost no human studies. Since then, there been no more human studies using transdermal progesterone. Instead, doctors are studying very
profitable toxic, dangerous, ineffective, and expensive patentable prescription drugs.
The Center for Drug Research in India performed four different studies that all showed how progesterone shrank enlarged rat prostates, and moderated the stimulating effects of
estrogen. The main study was published over forty years ago in Endokrinologie (v 55, 1970). Just giving progesterone to rats with BPH resulted in significantly reduced prostate volumes--and in only 30 days. This is nothing less than amazing- in only 30 days! Well-done animal studies
like this are very important precursors to human studies. There are many such studies in the scientific literature, but where are the human studies?
At Montreal General Hospital (Journal of Clinical Endocrinology and Metabolism v 39,
1974), researchers showed that progesterone strongly inhibited DHT formation in men. “The
ability of progesterone to inhibit DHT formation represents one mode of action which may account at least in part for their efficacy in treating BHP.” This happened over forty years ago.
At the Institute of Clinical Chemistry in Germany (Prostate v 6, 1985), doctors discovered that progesterone inhibited 5-alpha reductase in human prostates. This is what converts “good” testosterone into “bad” DHT. Researchers at St. George’s Hospital in London found the same effect (Journal of Endocrinology v 63, 1974). Progesterone was dramatically effective in inhibiting 5-alpha reductase and the conversion of testosterone into DHT. Similar Natural Prostate Cure,
results were demonstrated at the University of Mainze in Germany (Journal of Steroid Biochemistry v 6, 1975).
Head:Dosage
:You do not have to test your progesterone levels, and saliva testing does not work, as progesterone is fat-soluble. Progesterone is very poorly absorbed orally. If taken by mouth, it is broken down into unwanted metabolites. Fortunately, progesterone is readily absorbed through
the skin into the bloodstream; therefore, transdermal creams are very practical and effective. Find a good brand that contains 1000 mg of natural, pharmaceutical grade (USP) progesterone per two-ounce jar (500 mg per ounce). This should be stated clearly on the label. Apply one eighth
of a teaspoon of the cream on your inner wrist (any thin skin) five days a week. This allows the progesterone to enter the bloodstream, and reach the prostate receptors. Just one eighth of a teaspoon provides about 7 mg, of which about 2 mg should be absorbed into your system. Progesterone is completely nontoxic and very safe, especially in these small amounts.

Stand up against 5G
10/04/2020

Stand up against 5G

We are in the midst of a 5G wireless technology rollout, and politicians have yet to address safety concerns. I recently used Canadian Prime Minister Justin Trudeau as an example, but it’s happening worldwide. It’s one of many examples that illustrates how large corporations completely control p...

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