29/11/2025
Understanding more about topics like this really underpin any mood and anxiety concerns…
What's really going on?
MTHFR cranks out methyl groups to fuel dopamine and estrogen production.
COMT clears the excess—but only if it’s working fast enough 🥵.
❗ When COMT is slow, you’re making more than you can clear.
What It Feels Like 😵💫
• Dopamine dominance → irritability, obsessive thoughts, trouble winding down, overstimulated
• Estrogen buildup → PMS, heavy or painful periods, fibroids, endometriosis
• Histamine sensitivity → headaches, skin flushing, food reactivity, seasonal responses
What do I do?
🔁 Pulse Your Methyl Donors
Use the Pulse Method from Dr. Ben Lynch to match support to your needs. More is not always better. (https://www.seekinghealth.com/blogs/education/pulse-method?_pos=2&_sid=10d59dac9&_ss=r)
🧯 Support Slow COMT
Avoid high-dose dopamine precursors
💧 Drain the Estrogen (detox)
🧬 Map the Whole Picture
Use StrateGene® to see how your methylation and COMT pathways interact and where to target your support. (Right now, get it for 25% off during Black Friday)
🔆 More Gene Details/Expert Tips 🔆
What these SNPs may look like on a report.
COMT V158M (rs4680)
Met/Met (A/A): Slow
Val/Val (G/G): Fast
Val/Met (A/G): Intermediate
Methylation = a network, not a solo gene. COMT, MTHFR, MAOA, HNMT, PEMT, and others all affect each other. Cofactor nutrients matter: B2, B6, B12, folate, magnesium, zinc, choline = core team for methylation and COMT activity.
💬 Comment: COMT to learn more about this gene variation, if you might have it, and what supplements/guides we recommend.
or
💬 Comment “METHYLATE” to explore MTHFR and discover targeted methylated nutrients and supportive cofactors that align with your unique needs.
