18/02/2026
MGUS, or monoclonal gammopathy of undetermined significance, is a non-cancerous condition where a small number of abnormal cells in your bone marrow (the spongy centre of our bones) produces an abnormal protein that is detectable in the bloodstream. This abnormal protein is called paraprotein or M protein.
Each year, about 1% (1 in 100) people with MGUS will slowly progress to develop myeloma, or another serious condition such as chronic lymphocytic leukaemia (CLL), non-Hodgkin lymphoma, or AL amyloidosis.
Learn more about MGUS, how it’s diagnosed and how it’s managed in our new ‘Monoclonal gammopathy of undetermined significance’ Health condition infosheet:https://myeloma.org.au/wp-content/uploads/2025/11/MGUS-Conditions-infosheet.pdf