17/12/2025
...with over 20 new studies.
Much of the focus was on melatonin's role in antioxidant capacity. Overall, the studies found that melatonin’s antioxidant and anti-inflammatory properties support placental health, regulate immune homeostasis, and may protect against oxidative damage in the fetus, potentially improving perinatal outcomes
Here are the 3 I would read first.
1. Busetti, K., Simões, D., Braga, D., Setti, A., Borges, E., & De Sá, G. (2025). P-645 Melatonin supplementation during controlled ovarian stimulation for women undergoing assisted reproductive technology: systematic review and meta-analysis of randomized controlled trials. Human Reproduction. https://doi.org/10.1093/humrep/deaf097.951.
👉🏼Systematic review and meta-analysis of melatonin supplementation during controlled ovarian stimulation for ART
2. Bradfield, Z., White, S., Davies-Tuck, M., Sharp, M., Warland, J., Callander, E., Kuliukas, L., Rose, M., Pettitt, A., Ekin, K., Doherty, D., & Keelan, J. (2025). Double-blind, randomised, placebo-controlled trial to evaluate the effectiveness of late gestation oral melatonin supplementation in reducing induction of labour rates in nulliparous women: the MyTIME study protocol. BMJ Open, 15. https://doi.org/10.1136/bmjopen-2024-090370.
👉🏼MyTIME Study: Double-blind, randomised, placebo-controlled trial to evaluate the effectiveness of late gestation oral melatonin supplementation in reducing induction of labour rates in nulliparous women
3. Duka, Y., & Duka, D. (2025). The role of melatonin in the implementation of women's reproductive plans: from menarche to the physiological course of the gestational process (literature review). UKRAINIAN JOURNAL HEALTH OF WOMAN. https://doi.org/10.15574/hw.2025.1(176).7182.
👉🏼Narrative review summarizing preclinical and early clinical evidence on melatonin as an adjuvant therapy for preeclampsia.