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Metanalyses, Gateway Circular Quay, Sydney/Office Level 36, Gateway 1 Macquarie Place, North Sydney (2025)

26/08/2025

🅜🅔🅣🅐 Published Today (Philippines date: August 26, 2025)

This bibliometric analysis maps VR research in mental health—trends, key players, and emergent themes via CiteSpace visualization. (200 characters)

TITLE: A BIBLIOMETRIC STUDY OF THE EVIDENCE ABOUT APPLYING VIRTUAL REALITY IN MENTAL HEALTH CARE

🅼 Link: https://doi.org/10.2147/JMDH.S536946

🅼 Key Findings:

🔬 Exponential surge in VR-mental health publications since 2020, with over 110 articles annually.

🔬 A vast collaboration network: 3,587 authors; Giuseppe Riva is the most prolific author, University of London is top institution.

🔬 Main research clusters include virtual reality, exposure therapy, skin conductance, mild cognitive impairment, psychosis, augmented reality, serious games.

🔬 Keyword bursts (2014–2025) highlight emerging themes: “reality exposure therapy”, “PTSD”, “CBT”, “rehabilitation”, “AI”, “augmented reality”, “digital health”, “validity”, “impact”.

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🅼 Clinical Relevance:

VR is increasingly integrated into mental health care—as exposure therapy, cognitive rehabilitation, educational tools, and immersive interventions across disorders like anxiety, PTSD, ADHD, MCI, Parkinson’s, and chronic illness—offering scalable, engaging, and potentially more effective therapeutic options. (400 characters)

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26/08/2025

📣 🅜🅔🅣🅐 MetaPro Published Today (August 26, 2025) – A meta-analysis exploring neurotransmitter metabolite changes in Alzheimer’s disease, across brain, CSF, and blood (200 characters)

TITLE: GLUTAMATERGIC AND GABAERGIC METABOLITE LEVELS IN ALZHEIMER’S DISEASE: A SYSTEMATIC REVIEW AND META-ANALYSIS

🅼 Link: https://doi.org/10.1186/s12883-025-04375-2

🅼 Key Findings:

🔬 Glutamate is significantly lower in the cortex, hippocampus, temporal cortex, limbic system, and whole brain in AD patients—reflecting widespread synaptic degeneration.

🔬 No significant differences in glutamate levels were found in cerebrospinal fluid (CSF) or blood—suggesting central, rather than systemic, neurotransmitter loss.

🔬 Glutamine shows no significant alterations across brain regions, CSF, or blood—indicating its metabolism may remain intact in AD.

🔬 GABA levels are notably reduced in multiple brain regions, including cortex, hippocampus, cerebellum, limbic areas—as well as in CSF and blood—highlighting pervasive inhibitory neurotransmitter deficits.

🔬 The dual decline of glutamate and GABA suggests late-stage neurodegeneration, not excitotoxicity, leading to global neurotransmitter depletion.

🅼 Clinical Relevance:
This synthesis suggests that both excitatory (glutamatergic) and inhibitory (GABAergic) systems are compromised in Alzheimer’s disease, urging early-stage intervention strategies and biomarker development targeting neurotransmitter preservation.

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26/08/2025

📣 META Published Today (26 August 2025, Philippines) – Systematic review and meta-analysis evaluating AI for imaging-based lung cancer diagnosis and prognosis.

TITLE: SYSTEMATIC REVIEW AND META-ANALYSIS OF ARTIFICIAL INTELLIGENCE FOR IMAGE-BASED LUNG CANCER CLASSIFICATION AND PROGNOSTIC EVALUATION

🅼 Link: https://doi.org/10.1038/s41698-025-01095-1

🅼 Key Findings:

🔬 Analyzed 315 studies up to 7 January 2025, focusing on AI-based diagnosis and prognosis in lung cancer.

🔬 For 209 diagnostic studies, pooled sensitivity 0.86 (95% CI: 0.84–0.87), specificity 0.86 (95% CI: 0.84–0.87), and AUC 0.92 (95% CI: 0.90–0.94)

🔬 For prognosis (106 studies): sensitivity 0.83 (0.81–0.86), specificity 0.83 (0.80–0.86), AUC 0.90 (0.87–0.92)
🔬 Among 53 studies distinguishing low- vs high‑risk patients, pooled hazard ratios: overall survival HR 2.53 (95% CI: 2.22–2.89); progression‑free survival HR 2.80 (95% CI: 2.42–3.23)
🔬 Subgroup analyses indicated consistently acceptable performance across study types

🅼 Clinical Relevance:
AI-driven imaging shows strong diagnostic accuracy (AUC ≈ 0.92) and robust prognostic capabilities, effectively stratifying lung cancer patients by outcome risk and enhancing decision-making in clinical oncology care.

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26/08/2025

📣 META Published Today (August 26, 2025, Philippines)
TITLE: EFFECTS OF DIFFERENT EXERCISE INTERVENTIONS ON HEALTH STATUS IN OVERWEIGHT AND OBESE CHILDREN AND ADOLESCENTS

Link: https://doi.org/10.2147/DMSO.S528948

Key Findings:

🔬 HIIT (High-Intensity Interval Training) markedly improves cardiorespiratory fitness in overweight/obese youth, boosting VO₂peak by 3.33 mL·kg⁻¹·min⁻¹ (95% CI: 2.36 to 4.26) and reducing heart rate by 8.09 bpm (95% CI: −10.92 to −5.37).

🔬 Aerobic exercise (AE) significantly reduces weight, BMI, and waist circumference in this population.

🔬 Combined exercise (CE) appears most effective for lowering body fat percentage, waist-to-hip ratio, and enhancing fat-free mass, as well as improving fasting glucose and insulin resistance.

🔬 Resistance exercise (RE) shows the greatest benefit for improving lipid profiles.

🔬 This network meta-analysis of 51 randomized controlled trials with 2,263 participants systematically compares multiple exercise modalities to guide targeted interventions.

🔬 Provides evidence-based insights for clinicians and policymakers, though further high-quality RCTs are needed for stronger validation.

Clinical Relevance:
This NMA offers practitioners clear guidance: HIIT is especially powerful for enhancing aerobic capacity; AE and CE are effective for body composition improvements; RE helps manage lipids. Tailoring exercise prescriptions based on individual health goals (e.g. cardiovascular fitness vs. metabolic control) could enhance outcomes in overweight and obese youth.

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26/08/2025

📣 🅜🅔🅣🅐 Published Today (26 August 2025 – Philippines time)
Video game play and well-being during the COVID-19 pandemic: a meta-analysis of global findings (Humanities and Social Sciences Communications, published 26 August 2025)

TITLE: VIDEO GAME PLAY AND WELL-BEING DURING THE COVID-19 PANDEMIC: A META-ANALYSIS OF GLOBAL FINDINGS

🅼 Link: https://doi.org/10.1057/s41599-025-05581-6

🅼 Key Findings:

🔬 Meta-analysis of 17 studies (n = 18,026) shows a small but statistically significant increase in gaming time during the COVID-19 pandemic vs. pre-pandemic (Cohen's d = 0.26) within 95% CI [0.14, 0.37], p = 0.0004.

🔬 Gaming time showed no significant association with well-being or ill-being across 22 studies (100 effects, n = 19,752): r = −0.03 (95% CI [−0.08, 0.02], p = 0.22).

🔬 Moderator analysis revealed minimal variation across most subgroups, with slightly higher increases in gaming time during Q2 of 2020 and in Europe—but not Asia.

🔬 In Asia, more gaming was associated with lower well-being—but the effect was negligible.

🔬 Qualitative reports suggest that many players believed gaming improved their well-being during lockdowns, despite the neutral overall statistical association.

🔬 Publication bias evaluations (funnel plots, Egger’s tests) found no significant bias in either gaming time changes or gaming–well-being correlations.

🅼 Clinical Relevance:

Though gaming time rose modestly during the pandemic, it had negligible impact (positive or negative) on mental well-being. For clinicians, educators, and caregivers, these findings suggest that focusing on the quality and context of gaming experience—rather than merely the duration—may be more critical in assessing its psychological significance.

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25/08/2025

📣 🅜🅔🅣🅐 METAPRO Published Today (August 25, 2025, Philippines)
EFFECT OF FIVE NON-INVASIVE TREATMENTS ON BODY COMPOSITION, PHYSICAL FUNCTION AND QUALITY OF LIFE IN ELDERLY SARCOPENIA: A NETWORK META-ANALYSIS OF 22 RANDOMIZED CONTROLLED TRIALS — Evaluates how aerobic, resistance, combined training, whole-body electrical stimulation (WB-EMS), and WB-EMS plus protein affect fat, muscle, strength, and quality of life in elderly with sarcopenia.
TITLE: EFFECT OF FIVE NON-INVASIVE TREATMENTS ON BODY COMPOSITION, PHYSICAL FUNCTION AND QUALITY OF LIFE IN ELDERLY SARCOPENIA: A NETWORK META-ANALYSIS OF 22 RANDOMIZED CONTROLLED TRIALS

🅼 Key Findings:

🔬 ES&P (electrical stimulation plus protein supplementation) & AT (aerobic training) led to largest fat reduction (SMD = –3.33 and –1.31 respectively, both p < 0.00001)

🔬 RT (resistance training) significantly improved muscle mass (SMD = 0.50, p < 0.05)

🔬 RAT (combined resistance + aerobic training) produced the greatest strength gains (SMD = 0.51, p < 0.05)

🔬 RAT also most improved quality of life (SMD = 1.42, p < 0.05)

🔬 Different treatments excel in different outcomes — suggesting personalized, multi-modal therapy is optimal for sarcopenia management.

🅼 Clinical Relevance:
Multiple non-invasive interventions offer distinct benefits—combining training modalities (especially resistance + aerobic with protein or electrical stimulation) may maximize fat reduction, muscle gain, strength, and quality of life; personalization is key.

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25/08/2025

📣 🅜🅔🅣🅐 MetaPro Published Today — August 25, 2025 (Philippines)

📣 META Published Today — 25 August 2025
TITLE: PREVALENCE OF OSTEONECROSIS OF THE JAW FOLLOWING TOOTH EXTRACTION IN PATIENTS WITH OSTEOPOROSIS: A SYSTEMATIC REVIEW AND META-ANALYSIS**

🅼 Link: https://doi.org/10.3390/jcm14175988

🅼 Key Findings:

🔬 Pooled overall prevalence of MRONJ after tooth extraction in osteoporotic patients is 1.7% (95 % CI: 0.8–3.0 %).

🔬 Focusing on bisphosphonate-related osteonecrosis of the jaw (BRONJ), prevalence drops to 0.7% (95 % CI: 0.1–1.8 %).

🔬 Considerable heterogeneity among studies, with I² = 77% for MRONJ and I² = 61% for BRONJ.

🔬 Meta-regression found no significant influence from publication year, gender ratio, or extraction-to-patient ratio on prevalence estimates.

🔬 Highlights the need for consistent diagnostic criteria, preventive protocols, and multidisciplinary care to mitigate MRONJ risk.

🅼 Clinical Relevance:
This analysis highlights that MRONJ—while rare—is a real concern (≈1.7%) following tooth extraction in osteoporotic patients on antiresorptive therapy. Even bisphosphonate-specific risk at ≈0.7% justifies careful dental planning, standardized preventive protocols, and close interdisciplinary management to ensure safe extraction care.

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25/08/2025

📣 🅜🅔🅣🅐 METAPRO Published Today (Philippines date): 25 August 2025 - This meta-analysis correction highlights that Shufa Tan equally contributed to the systematic review and network meta-analysis on non-pharmacological treatments for functional constipation.

TITLE: CORRECTION: CLINICAL EFFICACY OF NON-PHARMACOLOGICAL TREATMENT OF FUNCTIONAL CONSTIPATION: A SYSTEMATIC REVIEW AND NETWORK META-ANALYSIS

🅼 Link: https://doi.org/10.3389/fcimb.2025.1680092

🅼 Key Findings:

🔬 Correction acknowledges that Shufa Tan was omitted as an equal contributing author alongside Chengtao Peng and Xin Lin, updating author contribution status.

🔬 The original study assessed efficacy of non-pharmacological interventions (e.g., dietary, mechanical, behavioral, microbiome-based) for functional constipation via systematic review and network meta-analysis.

🔬 Adds transparency and accuracy by ensuring proper attribution of equal contributions in critical authorial roles.

🔬 Highlights collaborative effort across multiple institutions in China, emphasizing integrative and extra-intestinal microbiome perspectives.

🔬 Enhances academic integrity by publicly correcting author contributions in this open-access article.

🔬 Demonstrates responsiveness of journal Frontiers in Cellular and Infection Microbiology in maintaining publication accuracy.

🅼 Clinical Relevance:
Ensuring accurate author contribution fosters fair academic recognition and credibility—critical in collaborative, evidence-synthesis studies influencing non-pharmacological approaches to managing functional constipation.

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25/08/2025

📣 🅜🅔🅣🅐 META Published Today (assuming Philippine date format: August 25, 2025) – A meta-analysis revealing how athletes’ brains integrate motor imagery and action anticipation through efficient, nested neural networks.
TITLE: BRAIN NETWORK OF ATHLETES IN MOTOR IMAGERY AND ACTION ANTICIPATION: AN ALE META-ANALYSIS AND MACM ANALYSIS

🅼 Link: https://doi.org/10.3389/fspor.2025.1652165

🅼 Key Findings:

🔬 Athletes show stronger activation in left middle frontal gyrus (MFG) & left precentral gyrus (PreCG) during motor imagery.

🔬 During action anticipation, athletes activate left superior frontal gyrus (SFG), bilateral PreCG, right MFG more than non-athletes.

🔬 Non-athletes rely more on visual regions (middle occipital gyrus) in anticipation tasks.

🔬 Athletes share overlapping activation (left MFG) across imagery and anticipation; non-athletes show distinct, non-overlapping patterns.

🔬 MACM shows athletes have bidirectional connectivity between motor imagery regions (MFG–PreCG), and tightly connected networks involving PreCG, SFG, MFG during anticipation.

🔬 Athletes display complex, nested simulation networks linking PreCG, inferior parietal lobule (IPL), temporal regions, insula, and claustrum during anticipation.

🔬 Non-athletes show more segregated, task-specific networks with limited integration.

🔬 This neural integration in athletes likely stems from experience-driven brain plasticity and enhances perceptual-motor expertise.

🔬 Limitations: cross-sectional design, small sample sizes, exploratory ALE method; longitudinal studies needed.

🅼 Clinical Relevance:
This meta-analysis uncovers how extensive athletic training fosters integrated, efficient sensorimotor networks for simulating and predicting actions—insights that could inform targeted neurorehabilitation and motor skill interventions to enhance motor learning in clinical populations.

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25/08/2025

📣 🅜🅔🅣🅐 MetaPro Published Today (25 August 2025) – Diagnostic and prognostic value of systemic immune-inflammation index for heart failure: a systematic review and meta-analysis is a study from Frontiers in Cardiovascular Medicine assessing how the systemic immune-inflammation index (SII) predicts outcomes in heart failure.

TITLE: DIAGNOSTIC AND PROGNOSTIC VALUE OF SYSTEMIC IMMUNE-INFLAMMATION INDEX FOR HEART FAILURE: A SYSTEMATIC REVIEW AND META-ANALYSIS

🅼 Link: https://doi.org/10.3389/fcvm.2025.1499449

🅼 Key Findings:

🔬 The systemic immune-inflammation index (SII), calculated from platelet, neutrophil, and lymphocyte counts, shows significant diagnostic accuracy for identifying heart failure.

🔬 Elevated SII levels correlate with poorer prognosis among heart failure patients, including higher mortality risk and hospitalization rates.

🔬 Across multiple studies, SII demonstrates consistent predictive value across both heart failure with reduced ejection fraction (HFrEF) and preserved ejection fraction (HFpEF).

🔬 Meta-analysis finds that high-SII patients have significantly worse outcomes compared to low-SII cohorts.

🔬 SII emerges as a readily accessible, cost-effective biomarker that could support clinical decision-making in heart failure management.

🔬 Potential applications include early risk stratification, guiding intensity of monitoring, and informing therapeutic strategies.

🅼 Clinical Relevance:
This meta-analysis underscores SII as an accessible blood-based biomarker with dual value: it helps diagnose heart failure and stratify patient risk. Clinicians may consider incorporating SII into routine evaluation to improve early detection and tailor monitoring strategies effectively.

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23/08/2025

📣 🅜🅔🅣🅐 Published Today (August 23, 2025 – Philippines)
A meta‑analysis examining how daily step counts relate to diverse health outcomes, finding ~7,000 steps/day delivers meaningful risk reductions.

TITLE:
DAILY STEPS AND HEALTH OUTCOMES IN ADULTS: A SYSTEMATIC REVIEW AND DOSE‑RESPONSE META‑ANALYSIS

🅼 Link: https://doi.org/10.1016/S2468-2667(25)00164-1

🅼 Key Findings:

🔬 ~7,000 steps/day (vs 2,000) linked to 47 % lower risk of all‑cause mortality (HR 0.53), 25 % lower cardiovascular disease incidence, 47 % lower CVD mortality, 37 % lower cancer mortality, 14 % lower type 2 diabetes incidence, 38 % lower dementia risk, 22 % lower depressive symptoms, and 28 % lower falls.

🔬 Dose‑response is mostly inverse and non‑linear: steep improvements up to ~5,000–7,000 steps/day, plateauing afterwards for many outcomes; some, like cancer incidence, show weak evidence (non‑significant 6 % reduction).

🔬 Evidence certainty is moderate for most outcomes, but lower for CVD mortality, cancer incidence, physical function, and especially falls (very low certainty).

🔬 While 10,000 steps/day remains beneficial, 7,000 appears a more realistic and evidence‑based public health target—particularly for less active populations.

🔬 Modest increases in daily steps (e.g., +1,000/day) yield tangible health gains; older adults may continue benefiting beyond 7,000 steps.

🅼 Clinical Relevance:
This study grounds the long-used 10,000-step guideline in real data, advocating ~7,000 steps/day as both achievable and clinically meaningful. It supports scalable public health messaging to reduce major health risks—even modest increases yield benefit—especially vital for older or less active adults.

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23/08/2025

📣 🅜🅔🅣🅐 META Published Today (23 August 2025, Philippines) – A meta‑analysis evaluating environmental enrichment (EE) interventions in infants with or at high risk of cerebral palsy, identifying optimal age windows for motor and cognitive improvements (200 characters)

TITLE: THE EFFECTS OF ENVIRONMENTAL ENRICHMENT IN INFANTS WITH OR AT HIGH RISK OF CEREBRAL PALSY: AN UPDATED SYSTEMATIC REVIEW AND META-ANALYSIS

🅼 Link: https://doi.org/10.1186/s12887-025-05954-5

🅼 Key Findings:

🔬 Environmental enrichment (EE) significantly improved motor development (SMD = 0.35; 95% CI 0.11–0.60; p=0.004)
DOI

🔬 Beneficial effects on gross motor function (SMD = 0.25; 95% CI 0.06–0.44; p=0.011)
DOI

🔬 No significant improvement in fine motor function (SMD = 0.20; 95% CI –0.04 to 0.43; p=0.109)
DOI

🔬 EE enhanced cognitive development (SMD = 0.32; 95% CI 0.10–0.54; p=0.004 after sensitivity analysis)
DOI

🔬 Optimal age for motor gains: 6–18 months – particularly strong between 6–12 and 12–18 months
DOI

🔬 Optimal age for cognitive gains: 6–12 months
DOI

🔬 Evidence quality varied: moderate for motor development; low for gross motor and fine motor; high for cognitive development
DOI

🔬 Interventions typically combined play-based sensory-motor stimulation, caregiver education, and social interaction
DOI

🅼 Clinical Relevance

EE protocols—such as COPCA, GAME, SPEEDI, START-Play—show small to moderate benefits in motor and cognitive domains during critical neuroplastic windows, especially between 6 and 18 months. For best outcomes, prioritize early, engaging, and caregiver-integrated stimulation tailored to developmental goals. Limits include small sample sizes and variable intervention quality, underscoring the need for standardized, high-quality future trials. (400 characters)

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Metanalyses

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