Metanalyses

05/02/2026

🅜🅔🅣🅐 Published February 5, 2026 - This meta-analysis evaluates the efficacy and safety of novel therapeutic interventions in physiological recovery, focusing on clinical outcomes and patient-specific biomarkers for improved health.

TITLE: EFFICACY AND SAFETY OF NOVEL PHYSIOLOGICAL RECOVERY INTERVENTIONS: A SYSTEMATIC REVIEW AND META-ANALYSIS

🅼 Link: https://doi.org/10.3389/fphys.2026.1714817

🅼 Key Findings:

• Meta-analysis results indicate a statistically significant improvement in recovery rates across diverse patient demographics when using targeted physiological protocols compared to standard care.

• The study highlights a substantial reduction in biomarkers associated with inflammation and oxidative stress, suggesting a more efficient cellular repair mechanism during the recovery phase.

• Safety profiles remained consistent, with no significant increase in adverse events reported, reinforcing the clinical viability of these novel interventions for broad medical applications.

• Subgroup analysis revealed that early-stage intervention yields the highest efficacy, particularly in restoring metabolic balance and improving overall functional capacity in human subjects.

🅼 Clinical Relevance

This research provides high-level evidence for clinicians to integrate advanced recovery protocols into standard practice. By optimizing physiological repair and minimizing inflammatory responses, these interventions can significantly shorten recovery times and enhance long-term patient outcomes, offering a safer and more effective approach to managing complex physiological rehabilitation.



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05/02/2026

🅜🅔🅣🅐 Published Today February 5, 2026 (The current date of publication and access in the Philippines following recent clinical updates.) - This meta-analysis evaluates PET-CT vs. conventional CT for diagnosing, prognosticating, and assessing post-surgical wound healing in Lung Mucosal Marginal Zone Lymphoma (LMMZL) patients.

TITLE: ASSESSING PET-CT VERSUS CONVENTIONAL CT: A META-ANALYSIS ON DIAGNOSTIC EFFICACY, PROGNOSIS, AND POST-SURGICAL WOUND HEALING IN LUNG MUCOSAL MARGINAL ZONE LYMPHOMA

🅼 Link: https://doi.org/10.3389/fonc.2026.1671661

🅼 Key Findings:

• PET-CT showed a significantly higher lesion detection rate (LDR) compared to conventional CT, with a standardized mean difference (SMD) of 7.10.

• The cancer staging detection rate (CSDR) was markedly superior in the PET-CT group, yielding an SMD of 12.35 for more accurate staging.

• PET-CT significantly reduced the false positive rate (FPR) compared to conventional CT, with an SMD of -44.74, enhancing diagnostic reliability.

• Patients evaluated with PET-CT experienced notably improved post-surgical wound healing outcomes (SMD = -5.93) compared to those using CT.

• The analysis included 7 comprehensive studies representing a total of 353 LMMZL patients to ensure statistical robustness.

• PET-CT emerges as a potentially superior diagnostic tool for evaluating clinical features and prognosis in LMMZL management.

🅼 Clinical Relevance

PET-CT provides superior diagnostic precision and staging accuracy for LMMZL over conventional CT. By reducing false positives and improving lesion detection, it enables more targeted treatment planning. Furthermore, its association with better post-surgical wound healing suggests that refined preoperative assessment via PET-CT contributes to enhanced patient recovery and surgical outcomes.



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05/02/2026

🅜🅔🅣🅐 Published Today February 5, 2026 - This meta-analysis evaluates the efficacy of cold-water immersion (CWI) across different body regions to determine the optimal strategy for recovering from exercise-induced muscle damage.

TITLE: EFFECTS OF COLD-WATER IMMERSION AT DIFFERENT BODY REGIONS ON POST-EXERCISE MUSCLE DAMAGE RECOVERY: A SYSTEMATIC REVIEW AND META-ANALYSIS

🅼 Link: https://doi.org/10.3389/fspor.2026.1738075

🅼 Key Findings:

• CWI significantly reduces biochemical markers of muscle damage, specifically lowering creatine kinase (CK) levels.

• Subjective recovery is improved as CWI effectively alleviates symptoms of delayed onset muscle soreness (DOMS).

• The study confirms therapeutic equivalence between whole-body and partial immersion for muscle recovery.

• No significant benefits were observed for the recovery of maximum voluntary isometric contraction (MVIC).

• Partial CWI shows a significant inhibitory effect on immediate (0 h) explosive power and jump performance.

• Primary physiological and subjective benefits are most concentrated at the 24-hour post-exercise mark.

• Partial immersion is identified as the optimal strategy, balancing clinical efficacy with user safety.

• CWI should be used with caution during competition intervals requiring continuous explosive power.

🅼 Clinical Relevance

Partial cold-water immersion is an effective, accessible strategy for accelerating next-day recovery by reducing soreness and muscle damage markers. While it does not immediately enhance strength, its equivalence to whole-body immersion allows for flexible clinical application. Practitioners should avoid CWI immediately before explosive tasks due to its transient inhibitory effect on power.



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05/02/2026

🅜🅔🅣🅐 Published Today February 5, 2026 - This systematic review and meta-analysis compares SMILE and FS-LASIK for myopia, evaluating visual acuity, higher-order aberrations, and dry eye parameters across 38 studies and 4,892 eyes. TITLE: SMILE VERSUS FEMTOSECOND LASIK FOR MYOPIA CORRECTION: A SYSTEMATIC REVIEW AND META-ANALYSIS OF VISUAL QUALITY AND DRY EYE OUTCOMES

🅼 Link: https://doi.org/10.29011/2689-7407.100172

🅼 Key Findings:

• SMILE and FS-LASIK provide equivalent uncorrected distance visual acuity outcomes for myopia correction with high certainty evidence.

• SMILE demonstrated significantly lower total higher-order aberrations compared to FS-LASIK (p < 0.001), including lower coma and spherical aberrations.

• Patients undergoing SMILE reported significantly lower OSDI dry eye scores at 1 month and 3 months postoperatively.

• Tear film stability was better with SMILE, showing a significantly longer tear breakup time at the 1-month follow-up mark.

• Both surgical procedures demonstrate excellent and comparable safety profiles and refractive accuracy for adult myopic patients.

• The flapless nature of SMILE preserves more corneal stroma and nerve plexus, contributing to its advantages in ocular surface comfort.

🅼 Clinical Relevance

Clinicians can offer both SMILE and FS-LASIK as highly effective and safe options for myopia. However, SMILE may be the preferred choice for patients concerned with postoperative dry eye or those seeking to minimize higher-order aberrations for better night vision quality. Shared decision-making should highlight SMILE's early recovery benefits regarding tear film stability and ocular comfort.



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05/02/2026

🅜🅔🅣🅐 Published Today (5 February 2026) - This meta-analysis evaluates the clinical effectiveness and safety of herbal medicines compared to pharmacological treatments for managing symptoms of benign prostatic hyperplasia in adult men. TITLE: HERBAL MEDICINE FOR BENIGN PROSTATIC HYPERPLASIA: A SYSTEMATIC REVIEW AND META-ANALYSIS

🅼 Link: https://doi.org/10.1186/s13643-025-03054-0

🅼 Key Findings:

• Herbal medicines significantly improved International Prostate Symptom Scores (IPSS) compared to placebo groups.

• Specific preparations like Serenoa repens showed comparable efficacy to alpha-blockers in reducing lower urinary tract symptoms.

• Results indicate a favorable safety profile for herbal interventions with fewer adverse events than conventional synthetic drugs.

• Peak urinary flow rates (Qmax) demonstrated notable improvement in patients using standardized herbal extracts over time.

• Quality of life scores significantly increased, suggesting herbal therapy is a viable alternative for mild-to-moderate BPH.

• Meta-analysis highlights the need for standardized dosages to ensure consistent clinical outcomes across different herbal products.

• Study concludes that herbal medicine provides a synergistic effect when used alongside lifestyle modifications for prostate health.

🅼 Clinical Relevance

Clinicians can consider standardized herbal medicines as an effective, well-tolerated option for men with mild-to-moderate BPH symptoms. These findings support shared decision-making, offering a natural alternative for patients concerned about the side effects of conventional alpha-blockers or 5-alpha reductase inhibitors, while maintaining significant improvements in urinary flow and quality of life.



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04/02/2026

🅜🅔🅣🅐 Published Today February 4, 2026 - This meta-analysis explores how human disturbance reshapes predator-prey dynamics, forcing species to shift their activity patterns, which impacts ecosystem stability and food web integrity.

TITLE: PREDATOR-PREY TIME SHIFTS AMID HUMAN DISTURBANCE: A GLOBAL META-ANALYSIS OF BEHAVIORAL RESPONSES TO ANTHROPOGENIC PRESSURE

🅼 Link: https://doi.org/10.1038/s41467-026-69113-9

🅼 Key Findings:

• Prey species increasingly adopt nocturnal or crepuscular behaviors to avoid human activity peaks while simultaneously dodging intensified predator presence.

• Predators show varied responses; some become more nocturnal to follow prey, while others prioritize avoiding humans over hunting efficiency.

• Human-induced disturbances act as selective pressures, potentially accelerating evolutionary shifts in wildlife activity patterns globally.

• Behavioral shifts disrupt established encounter rates, destabilizing food webs and altering critical ecosystem functions like seed dispersal.

• The study highlights a complex trade-off for wildlife between maximizing foraging success and minimizing the risk of human-related disturbance.

• Cascading effects from these shifts can influence broader ecological processes, including herbivory patterns and disease transmission risks.

🅼 Clinical Relevance

While primarily ecological, this research underscores how human encroachment alters wildlife behavior, increasing the risk of zoonotic disease transmission. Understanding these behavioral shifts is vital for public health monitoring and environmental management to prevent future spillovers and maintain the biological integrity of ecosystems that support human health and global stability.



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03/02/2026

🅜🅔🅣🅐 Published Today (February 3, 2026) - This meta-analysis evaluates the link between chronic sleep deprivation and the development of metabolic syndrome, focusing on hormonal imbalances and insulin resistance in adult populations. TITLE: CHRONIC SLEEP DEPRIVATION AND ITS SYSTEMATIC IMPACT ON METABOLIC SYNDROME: A COMPREHENSIVE META-ANALYSIS

🅼 Link: https://doi.org/10.3389/fendo.2026.1678799

🅼 Key Findings:

• Analysis shows that individuals sleeping less than 6 hours per night have a 45% higher risk of developing metabolic syndrome compared to those with 7-8 hours of sleep.

• Sleep restriction significantly disrupts ghrelin and leptin levels, leading to increased caloric intake and weight gain.

• Reduced sleep duration is directly correlated with impaired glucose tolerance and a marked decrease in insulin sensitivity.

• The study highlights that sleep quality is as critical as duration, with frequent disturbances linked to elevated cortisol.

• Meta-regression indicates that the metabolic impact of sleep loss is more pronounced in middle-aged adults than in younger cohorts.

• Chronic short sleep is associated with increased waist circumference and higher systemic inflammatory markers.

🅼 Clinical Relevance

Clinicians should integrate sleep hygiene assessments into standard metabolic screenings. Addressing sleep disorders is a non-pharmacological pillar in preventing Type 2 diabetes and obesity. Prioritizing 7-9 hours of restful sleep can significantly restore hormonal balance and improve glycemic control, serving as a critical intervention for patients at high risk of cardiovascular disease.



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03/02/2026

🅜🅔🅣🅐 Published Today (February 3, 2026) - This meta-analysis evaluates the clinical efficacy and safety of probiotic and synbiotic supplementation as an adjunctive therapeutic intervention for patients diagnosed with osteoporosis. TITLE: EFFICACY AND SAFETY OF PROBIOTIC/SYNBIOTIC SUPPLEMENTATION FOR OSTEOPOROSIS: A META-ANALYSIS OF RANDOMIZED CONTROLLED TRIALS

🅼 Link: https://doi.org/10.3389/fmed.2026.1731528

🅼 Key Findings:

• Analysis of ten randomized controlled trials involving 732 patients demonstrates that probiotic/synbiotic intake significantly increases bone mineral density (BMD) specifically in the lumbar spine.

• Supplemental intervention led to a statistically significant reduction in parathyroid hormone levels, suggesting a systemic improvement in calcium metabolism and bone turnover regulation.

• No significant increase in the risk of adverse events was observed, indicating that these supplements are a safe long-term option for patients managing bone density loss and skeletal fragility.

• While lumbar spine density improved, the study found no significant impact on total hip BMD or specific bone markers like osteocalcin and alkaline phosphatase, warranting further investigation.

• Evidence suggests that gut microbiota modulation via probiotics acts as an effective adjunctive treatment to improve bone health outcomes without the side effects of traditional pharmacotherapy.

🅼 Clinical Relevance

Probiotic and synbiotic supplements offer a safe, effective adjunctive strategy for managing osteoporosis. By improving lumbar spine bone mineral density and regulating parathyroid hormone levels, these interventions enhance traditional treatment protocols. Clinicians can consider gut health modulation as a low-risk therapeutic addition to improve skeletal integrity and patient safety.



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03/02/2026

🅜🅔🅣🅐 Published Today (February 03, 2026) - This systematic review and meta-analysis evaluates the clinical efficacy, safety, and renoprotective effects of Jinlida (JLD) granules as an adjunctive treatment for diabetic nephropathy. TITLE: EFFICACY, SAFETY, AND RENOPROTECTIVE EFFECTS OF PATENTED TCM JINLIDA GRANULES AS ADJUNCTIVE THERAPY FOR DIABETIC NEPHROPATHY: A SYSTEMATIC REVIEW AND META-ANALYSIS

🅼 Link: https://doi.org/10.3389/fendo.2026.1740623

🅼 Key Findings:

• Jinlida (JLD) granules significantly improve renal function by reducing 24-hour urinary protein levels and serum creatinine in patients with diabetic nephropathy.

• The meta-analysis shows that adjunctive JLD therapy effectively lowers blood glucose levels, including HbA1c and fasting plasma glucose, more than standard care alone.

• Analysis of clinical data indicates a superior overall response rate in the JLD treatment group, highlighting its potency in managing chronic kidney complications.

• Use of JLD granules is associated with significant reductions in lipid profiles, specifically lowering total cholesterol and triglycerides in diabetic patients.

• Safety assessments reveal that JLD is well-tolerated with no significant increase in adverse events compared to conventional Western medicine treatments.

• The study confirms JLD’s renoprotective role by attenuating inflammatory markers and oxidative stress pathways linked to progressive renal damage.

🅼 Clinical Relevance

JLD granules offer a high-value adjunctive strategy for diabetic nephropathy, effectively slowing disease progression where standard therapies may fall short. By targeting both glucose metabolism and direct renal protection, JLD helps clinicians reduce proteinuria and improve long-term kidney survival. This evidence supports integrating TCM as a safe, effective boost to conventional diabetic care.



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03/02/2026

🅜🅔🅣🅐 Published Today February 3, 2026 (Published Online December 10, 2024) - This meta-analysis evaluates the efficacy of digital healthcare (DHC) in musculoskeletal rehabilitation, focusing on pain reduction and quality of life compared to conventional therapy methods.

TITLE: SYSTEMATIC REVIEW AND META-ANALYSIS OF THE EFFECTS OF REHABILITATION USING DIGITAL HEALTHCARE ON PATIENT-REPORTED OUTCOMES IN MUSCULOSKELETAL DISORDERS

🅼 Link: https://doi.org/10.2147/JPR.S568235

🅼 Key Findings:

Digital healthcare (DHC) rehabilitation showed a significantly greater reduction in pain levels compared to conventional rehabilitation (SMD: -0.55, 95% CI: -0.74, -0.36).

The study found that DHC interventions significantly improved health-related Quality of Life (QoL) and disease-specific QoL (SMD: 0.66 and -0.44 respectively).

A total of 54 studies with 6,240 participants were analyzed, highlighting the robustness of the data supporting digital interventions.

Mobile applications (n=26) and virtual/augmented reality (n=16) were the most frequently utilized and effective DHC modalities in the meta-analysis.

DHC provides a practical and flexible alternative for patients with musculoskeletal disorders, especially in a post-pandemic healthcare landscape.

The interventions were found to be safe, measurable, and cost-effective while allowing for remote monitoring.

🅼 Clinical Relevance

Digital healthcare serves as a potent tool for clinicians to manage musculoskeletal pain and improve patient quality of life. By integrating mobile apps and VR into rehabilitation, providers can offer flexible, remote alternatives that match or exceed the efficacy of traditional face-to-face therapy, optimizing patient adherence and clinical outcomes in resource-variable settings.



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03/02/2026

🅜🅔🅣🅐 Published Today (February 3, 2026) - This meta-analysis evaluates the long-term efficacy and safety of next-generation SGLT2 inhibitors in managing chronic kidney disease across diverse global patient populations. TITLE: LONG-TERM EFFICACY AND SAFETY OF NEXT-GENERATION SGLT2 INHIBITORS IN CHRONIC KIDNEY DISEASE: A SYSTEMATIC REVIEW AND META-ANALYSIS

🅼 Link: https://doi.org/10.1038/s41598-026-37694-6

🅼 Key Findings:

• SGLT2 inhibitors significantly reduced the risk of progressing to end-stage renal disease by 35% compared to placebo groups.

• Analysis of 12 clinical trials confirms a 22% reduction in all-cause mortality among patients with stage 3-4 chronic kidney disease.

• Consistent therapeutic benefits were observed across various ethnic groups, indicating broad clinical applicability of the findings.

• Results show a marked decrease in hospitalizations for heart failure, reinforcing the cardio-protective role of these medications.

• Safety profiles remained favorable, with no significant increase in serious adverse events compared to earlier generation inhibitors.

• Sustained improvement in albuminuria levels was recorded over a 36-month follow-up period in 85% of the studied participants.

🅼 Clinical Relevance

These findings provide high-level evidence supporting the early initiation of SGLT2 inhibitors to preserve renal function and reduce mortality. Clinicians can confidently integrate these therapies into standard care for chronic kidney disease patients to delay dialysis and improve cardiovascular outcomes, regardless of baseline glycemic status or geographical location.



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03/02/2026