
25/08/2025
Thyroid nodules are common and affect half of the general population by the age of 60 years. The causes are believed to be due to hypothyroidism, mutational changes or autoimmunity. They can be associated with over- or underactivity of the gland and may sometimes be malignant.
Dill (Anethum graveolens L.) has been used in Turkey to self-treat thyroid dysfunction such as hyperthyroidism and hypothyroidism. Now a controlled clinical study has evaluated the impact of dill on patients with thyroiditis and benign thyroid nodules. They were divided into two groups: placebo (n =35) and dill group (n = 33). Dried and ground dill (300 mg) was put into capsules and patients on active treatment were given three capsules per day for 90 days. Various tests were conducted at the beginning and end of the study, including thyroid stimulating hormone (TSH), free triiodothyronine (FT3), free thyroxine (FT4), anti-thyroid peroxidase (anti-TPO), anti-thyroglobulin (anti-Tg), and C-reactive protein (CRP), and thyroid nodule dimensions were measured by ultrasound.
After 90 days, compared to the control group, the dill group exhibited significantly decreased TSH (by an average of 19% from a mean starting value of 2.69 compared to a 16% increase in the control group, P = 0.009), fT4 (P < 0.001), anti-TPO (P = 0.001), CRP (P < 0.001) and nodule size (by an average of 7.3% compared to a 4.5% increase in the control group, P < 0.001).
The authors concluded that dill suppressed inflammation of the thyroid gland, reduced nodule size, and lowered TSH levels in patients with thyroiditis and nodular goitre. The daily dose used was relatively low and higher doses might deliver a greater magnitude of clinical effects.
For more information see: https://pubmed.ncbi.nlm.nih.gov/40329862/