
20/07/2023
Researchers have made a groundbreaking discovery about metabolic health and aging! π
A study in 2021 investigated the effects of Nicotinamide Mononucleotide (NMN) supplementation on postmenopausal women with prediabetes who were overweight or obese. πΊ
NMN is crucial for the biosynthesis of NAD+, an essential molecule for metabolic function. Previous studies in rodents showed that obesity and aging impair NAD+ biosynthesis, leading to metabolic dysfunction. π
In this 10-week, randomized, placebo-controlled, double-blind trial, the results were incredible! The group receiving NMN supplementation experienced:
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Improved insulin-stimulated glucose disposal
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Increased skeletal muscle insulin signalling (phosphorylation of AKT and mTOR)
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Up-regulation of genes related to muscle remodelling, including platelet-derived growth factor receptor Ξ²
These findings suggest that NMN supplementation may enhance muscle insulin sensitivity, insulin signalling, and muscle remodelling in postmenopausal women with prediabetes who are overweight or obese. πͺ
This study opens up exciting possibilities for addressing metabolic dysfunction in this specific population. π Let's stay tuned for further developments in this exciting area of research! π€©
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