 
                                                                                                    23/10/2025
                                            Amputation for CRPS: What This New Study Reveals
Amputation for complex regional pain syndrome (CRPS) is one of the most controversial and emotionally charged decisions in pain medicine. For some people, the pain becomes so unbearable that removing the limb feels like the only way forward. It is a decision born from exhaustion, fear, and hope all at once.
A new long-term study from Erasmus MC in the Netherlands followed 39 patients who underwent amputation for severe, therapy-resistant CRPS. These were individuals who had already tried every available medical, interventional, and psychological treatment.
The results were striking:
 • Pain dropped on average by almost 3 points, even years later
 • 94% said they were satisfied and would choose amputation again
 • Quality of life and function improved, though not for everyone
 • Yet phantom and residual limb pain remained common, affecting most patients.  The stats were
 • 77% limb pain
 • 85% phantom pain
 • 10% CRPS in stump
The findings remind us that amputation is not a cure, but for some, it can bring a measure of peace and the ability to reclaim parts of life once lost. It remains a true last-resort option,  one that must be discussed openly, compassionately, and only in specialised multidisciplinary centres where the emotional, physical, and ethical complexities are fully understood.
At Pain Specialists Australia, we believe this study reinforces the importance of early, structured, specialist care for CRPS,  to give patients every chance at recovery before such irreversible decisions are even considered.
How should specialists and patients decide when “enough is enough” in severe CRPS?
https://ow.ly/6BsU50XgCvz                                        
 
                                                                                                     
                                                                                                     
                                                                                                     
                                                                                                     
                                                                                                     
                                                                                                     
                                                                                                     
                                                                                                     
                                                                                                     
                                         
   
   
   
   
     
   
   
  