11/03/2026
Coming Soon: Why Does Knee Pain Persist After a “Perfect” Knee Replacement?
We are putting the final touches on our next YouTube video looking at one of the most frustrating experiences patients face after surgery.
Your knee replacement looks perfect on X-ray.
Your surgeon says the operation went well.
But months later the pain is still there.
If this sounds familiar, you are not alone. Around 1 in 5 patients experience chronic pain after knee replacement surgery. This condition is known as chronic post-surgical pain (CPSP) and it is increasingly recognised as a problem of pain biology and nerve signalling, not simply joint mechanics.
Our upcoming video explores exactly why this happens and what can be done about it.
In the meantime, a recent review paper provides an excellent overview of the science behind this condition.
Banks DW, Park H, Oehlermarx W, et al. Chronic Post-Surgical Pain After Hip and Knee Arthroplasty: An Update on Mechanisms, Risk Factors, and Interventional Treatment Modalities. J Pain Res. 2025 Nov 20;18:6205-6219. https://ow.ly/CKae50YsChi
The authors highlight several important themes.
Why pain can persist after joint replacement
• Changes in the way nerves around the joint transmit pain signals
• Central sensitisation, where the nervous system becomes hypersensitive
• Ongoing inflammation and neuro-immune activation
• Pre-existing pain conditions that prime the nervous system
Who may be at higher risk
• Patients with severe pain before surgery
• Anxiety, depression, or pain catastrophising
• Widespread pain conditions such as fibromyalgia
• Surgical and tissue factors affecting nerve pathways
Emerging treatment approaches
• Targeted nerve blocks
• Genicular nerve procedures
• Radiofrequency neurotomy
• Neuromodulation strategies in selected patients
The key message is simple but important.
Persistent pain after joint replacement is real.
And understanding the underlying neurobiology of pain is often the first step toward finding better treatment options.
Our new video breaking this down for patients and families will be released within the next 48 hours.
Check out our YouTube channel here https://ow.ly/8ogj50YsChe
Get in touch here https://ow.ly/UZu050YsChh
In the meantime, if you have experienced pain after a knee replacement, what is the one question you would most like answered about why this happens?