14/09/2025
think about it? monkfruit is a natural, very low calorie sweetener
A recent review examined the effects on the gut microbiome of four different types of non-nutritive sweeteners.
The researchers found that many animal studies report a decrease in beneficial bacteria like Bifidobacterium and Lactobacillus, and an increase in harmful strains such as Clostridium difficile and E. coli, potentially leading to inflammation and gut imbalance.
Disruptions in short-chain fatty acid (SCFA) production and gut hormone signalling have also been observed.
The results of studies in human have been mixed. Some studies have shown that artificial sweeteners can cause dysbiosis and greatly reduce bacterial diversity. For example a clinical trial with healthy young adults demonstrated that consumption of 48 mg of sucralose every day for ten weeks induced gut dysbiosis by increasing Blautia coccoides and decreasing Lactobacillus acidophilus.
However, other human studies have shown milder negative effects than the animal studies or no significant changes. Differences in study design, dosage, shorter exposure time, and sweetener type likely contribute to these varied outcomes.
Whilst the results were mixed, the overall results of these studies may give you pause for thought. Occasional consumption of artificial sweeteners is unlikely to cause problems, but it's possible that regular daily consumption may.
Find out more about artificial sweeteners and their effects on the gut and metabolism in our latest blog here
https://www.noisyguts.com/blog/why-we-dont-use-artificial-sweeteners