07/02/2025
Creatine is so underrated as a supplement. I’d love to see a study that combines creatine + exercise in depression next ! :-)
In this 8-week randomized controlled trial in 100 adults with depression (50 men and 50 women), daily supplementation with creatine monohydrate improved depression symptoms more than a placebo.
These results add to a growing body of evidence suggesting that creatine supplementation can help with clinical depression. What makes this study unique is that it’s the first major clinical trial to look at whether creatine can improve depression in people not taking any psychotropic medication, like an SSRI. Instead, participants were only being treated with cognitive behavioral therapy.
More research is needed to determine how creatine exerts its antidepressant effects, but one theory is that creatine might modulate various neurotransmitter pathways, activating some (e.g., serotonin, dopamine, and norepinephrine) and inhibiting others (NMDA).
PMID: 39488067
Learn more: https://examine.news/fb250207