HEADBOX Lab

28/01/2025

We are conducting a Delphi study aiming to gain expert consensus around the administration of ketogenic therapies in order to propose best practice guidelines for implementation in clinical practice and for clinical trial design.

This is a much-needed step in standardising research to support evidence-based prescribing of these therapies.

The survey is anonymous and should take no more than 15 minutes of your time.

For more information, or if you are ready to participate, please copy and paste the link below into your browser: https://lnkd.in/g3wQ727q

Please share this far and wide within your networks!

This link will take you to a page that’s not on LinkedIn

25/01/2024

📢 Attention all cognitive neuroscientists and psychophysiologists! We are recruiting!

We have a 3-year, full-time position available as a Technical Support Officer to run research activities in our clinical laboratory!

Applications due 20:30 AEDT on 8 February, 2024!

More details and information on how to apply via the link below!

This position will play a key role in undertaking technical support for research activities

03/11/2023

📣 Our very own A/Prof Steiner-Lim is a keynote speaker at this year's Australasian Society for Psychophysiology, Inc. annual meeting in Hobart Tasmania in December!

Conference Dec 4 - 6 2023 Hobart, Tasmania
Register today http://socialneuro.com/asp2023
Keynote Speaker

Associate Professor Genevieve Steiner-Lim
PhD, BPsych (Hons, Class I)
University of Western Sydney

Genevieve is an NHMRC Emerging Leadership Fellow and the Clinical Research Platform Lead at NICM Health Research Institute, Western Sydney University. Her research program spans the early detection, prevention, and treatment of cognitive decline in older people with the aim of reducing dementia risk and improving quality of life. She combines psychophysiological and neuroimaging methods with other interdisciplinary research techniques – such as clinical trials, mixed-methods, neuropsychology, machine learning, metabolomics, immune and genetic markers – to test novel therapeutics that can provide early intervention for dementia with a focus on herbal medicine, nutraceuticals, and lifestyle.

Since completing her PhD in 2015 under the mentorship of Profs Robert Barry and Craig Gonsalvez at the University of Wollongong, A/Prof Steiner-Lim has attracted >$16.4M AUD in grant funding including two back-to-back NHMRC Fellowships, 22 awards and prizes, and has published over 85 peer reviewed publications in high impact journals. She currently leads a team of 15 in the HEADBOX Lab comprising research fellows, postdocs, research assistants, and higher degree research students.

Her current focus is on applying psychophysiological methods including EEG, ERPs, TMS, and autonomic measures to better understand dementia risk and response-to-treatment with medicinal cannabis, herbal and nutritional supplements, cognitive training, and non-invasive brain stimulation.

11/10/2023

Very excited to announce the findings from our clinical trial on SaiLuoTong (SLT) for mild cognitive impairment (MCI) led by A/Prof Genevieve Steiner-Lim! 🧠

💫 People with MCI have an increased risk
💫 Currently there are no approved treatments for

We trialled 12-weeks of SLT - a standardised herbal medicine formulation - in 78 people with MCI and found that SLT:
📌 Improved verbal retrieval
📌 Enhanced executive function
📌 Was safe and well-tolerated

This is an important development in the treatment of MCI, but more research is needed with a larger study over a longer timeframe to see if we can replicate these findings or whether SLT can potentially prevent dementia.

Thank you National Health and Medical Research Council - NHMRC for funding and NICM Health Research Institute for supporting this work!

📑 Full article available here: https://alz-journals.onlinelibrary.wiley.com/doi/full/10.1002/trc2.12420
🗞 Read more in the media release below 👇

Published in 's & Dementia: Translational Research & Clinical Interventions, a journal of the Alzheimer's Association

https://www.westernsydney.edu.au/nicmhri/news/significant_development_in_mild_cognitive_impairment_treatment_revealed_in_australia

Western Sydney University’s NICM Health Research Institute has led a world-first clinical trial in Australia that offers new hope in the treatment of mild cognitive impairment (MCI) (opens in a new window) among older people. The trial’s results, published in Alzheimer's and Dementia: Diagnosis,...

26/09/2023

📢 New paper alert!

Our integrated care case published in International Journal of Integrated Care provides a gold standard framework for conducting needs assessments in community aged care settings.

Free download 👇

https://ijic.org/articles/10.5334/ijic.7005

International Foundation for Integrated Care Western Sydney University

Introduction: Well-integrated community aged care services empower and enable older people to live and thrive in the community by supporting activities of daily living. To inform integrated community aged care service planning and delivery in South Western Sydney Australia, a needs assessment with c...

11/09/2023

Very excited to announce that A/Prof Genevieve Steiner-Lim and team were successfully awarded $217K from a Maridulu Budyari Gumal (SPHERE) Seed Funding Grant:

🚑🏥 Project AI-ED: Using artificial intelligence to promote integrated care quality for older people by reducing preventable emergency department presentations

Our Big Idea💡
📌Provide the right care at the right time in the right place for older people - which may not be the emergency department
📌Enable older people to be cared for outside the hospital by promoting early intervention that integrates primary and community care

27/08/2023

Our team just returned from Geneva, Switzerland after presenting a symposium on the clinical applications of a new data-driven analytical technique - frequency principal components analysis 🧠⚡️

legends Katerina Christofides and Adele Cave presented alongside Dr Frances De Blasio and A/Prof Genevieve Steiner-Lim at

24/08/2023

📢 New paper alert! 🧠

We assessed how different components mirrored the skin conductance response (SCR) orienting reflex:

📌 SCR ⬆️ significant stimuli and slower to habituate at longer interstimulus intervals
📌 5 x P3 components reflected different stimulus evaluation processes
📌 P3 ≠ SCR

Although the P300 event-related potential (ERP) is the most likely central measure of Sokolov’s Orienting Reflex (OR), there are few systematic comparisons with the skin conductance response (SCR), the “gold standard” electrodermal OR measure. We examine habituation, stimulus significance, and...

22/08/2023

📢📢 New paper alert! superstar, Adele Cave systematically reviewed evidence on the safety and efficacy on cognition of herbal and nutritional medicine for older people with and without subjective cognitive impairment:

📌 Data from 21 randomised controlled trials 📋
📌 Ginkgo and brahmi were the most studied herbs 🌿
📌 Low quality evidence in 95% of studies 😱

Background Subjective cognitive impairment (SCI) substantially increases dementia risk and is often conceptualised as the preclinical asymptomatic phase of the cognitive decline continuum. Due to the lack of pharmacological interventions available to treat SCI and reduce dementia risk, and the popul...

21/08/2023

Congratulations to these two legends - Ali Butt and Eman Shatnawi submitted their Masters of Research theses!

Ali assessed the concentration of herbal medicine (SLT) metabolites in the blood and how they predicted changes in cognitive function in people with mild cognitive impairment 🌿🧠

Eman's thesis explored a diversity-first approach to the design of inclusive initiatives including a dementia friendly community in Canterbury-Bankstown in South West Sydney, Australia!

17/08/2023

This September to November, we are hosting a series of FREE workshops to support people living with dementia in our community!

These practical and interactive workshops were co-created with people who have lived and caring experiences. Anyone can attend (plus you get a free lunch). To book, please call 0405 709 137.

These workshops will be hosted at NICM HRI, Western Sydney University's Westmead campus.

13/04/2023

Huge congratulations to super star ✨⭐ Joelle Metri for submitting her thesis!

Such an important piece of work on minimally invasive metabolic biomarkers for disease risk.