Evergreen Doctors

13/03/2025

Brain aging shows nonlinear transitions, suggesting a midlife “critical window” for metabolic intervention.

Age-related cognitive decline is associated with metabolic, vascular, and inflammatory changes, making it challenging to distinguish primary causes from secondary (downstream) effects. This study demonstrates that brain aging follows a specific progression, with the first stage occurring in middle age and coinciding with increased insulin resistance.

Moreover, the researchers showed that brain areas that age fastest are also those most vulnerable to neuronal insulin resistance.

Importantly, taking exogenous ketones, (which can fuel neurons while bypassing insulin resistance), reverses brain aging effects.

However, this intervention is only effective when provided early enough for neurons to remain viable.

Ketones exhibit robust effects in restabilizing brain networks, maximized from ages 40 to 60, suggesting a midlife “critical window” for early metabolic intervention.

These findings contribute to our understanding of brain aging mechanisms and suggest neurometabolic strategies for targeted early intervention in preventing age-related cognitive decline.

You can purchase exogenous ketones here: https://optilabs.com.au/products/ketone-ester-drink

Learn about the Evergreen Doctors approach to optimising brain health here: https://www.evergreendoctors.com/cognition

Study link:
https://www.pnas.org/doi/10.1073/pnas.2416433122

02/08/2024

A new study has found that pesticides may increase the risk of cancer more than smoking. More research is clearly needed but this could be a major source of disease in our society, that is largely ignored by the health system.

Professor Zapata and collaborators found that simply living near farms was enough to increase a person’s risk of cancers and in some cases, that increased cancer risk surpassed cancers caused by smoking. The strongest cancer risks were for non-Hodgkin’s lymphoma, leukaemia, and bladder cancer. Most disturbing was the finding that cancer risks due to pesticide exposures were actually higher for these particular forms of cancer than due to the risks from smoking.

Are one or two pesticides more dangerous than all the others?

“We present a list of major pesticide contributors for some specific cancers, but we highlight strongly that it is the combination of all of them and not just a single one that matters,” Professor Zapata explained. This list names 69 different agricultural pesticides for which use data are publicly available from the United States Geological Survey.

But these pesticides aren’t used used at a time. Instead, they are applied as pesticide “cocktails”, and thus, it is unlikely that just one or a few are to blame.

“In the real world, it is not likely that people are exposed to a single pesticide, but more to a cocktail of pesticides within their region,” Professor Zapata cautioned.

This study is the first comprehensive examination of cancer risks due to pesticide exposures with a population-based perspective at a national level, according to Professor Zapata and collaborators. Further, this is the first time that cancer risks due to pesticide exposures have been placed into a context with a cancer risk factor that is no longer questioned, in this case smoking.

Do you want a comprehensive approach to your wellbeing? At Evergreen Doctors, our goal is to help you optimise your health in all ways! https://www.evergreendoctors.com/approach

https://www.frontiersin.org/journals/cancer-control-and-society/articles/10.3389/fcacs.2024.1368086/full

Pesticides are an essential feature of modern-day agriculture that adds to the list of factors that increase cancer risk. Our study aims to comprehensively e...

17/07/2024

New study finds the exact amount of differernt types of exercise needed to help adults with major depressive disorder.

The researchers found you need the equivalent of 245 min of walking, 140 min of moderate-intensity aerobic exercise, or 215 min of yoga per week.

Exercise is medicine!

It helps our mitochondria and our whole being. Increase movement today.

Learn about the Evergreen Doctors holistic approach to mental health here: https://www.evergreendoctors.com/mental-health

https://www.sciencedirect.com/science/article/abs/pii/S0022395624003583

Our doctors use a holistic, personalised, nutrition-first-drugs-last, Functional Medicine approach.

17/07/2024

Early life antibiotics can cause allergies and asthma later in life by disrupting the gut microbiomta.

A new study done at Monash University found that mice given antibiotics in early life, but not in adulthood, were more susceptible to house dust mite induced allergic airway inflammation.

This susceptibility was maintained even after normalization of the gut microbiome.

The early antibiotics decreased systemic levels of indole-3-propionic acid (IPA), which induced long-term changes to cellular stress, metabolism, and mitochondrial respiration in the lung epithelium.

IPA reduced mitochondrial respiration and superoxide production and altered chemokine and cytokine production.

Also, early-life IPA supplementation protected the mice against the induced allergic airway inflammation in adulthood.

These results reveal a mechanism through which antibiotics given to young children, can predispose the lung to allergic airway inflammation and highlight a possible preventative approach to mitigate the detrimental consequences.
https://www.cell.com/immunity/abstract/S1074-7613(24)00316-9

Learn about the Evergreen Doctors approach to optimising gut health here: https://evergreendoctors.com/gut

Our doctors use a holistic, personalised, nutrition-first-drugs-last, Functional Medicine approach.

18/04/2024

Consuming more than two liters of diet softdrink or other artificially sweetened drinks a week could increase the risk of a dangerous irregular heartbeat by 20% compared with people who drink none, according to a new study.

https://www.ahajournals.org/doi/10.1161/CIRCEP.123.012145

At Evergreen Doctors we focus on the foundations of health, and aim to optimise your health in all areas. We use a nutrition first, drugs last approach. Learn more about our holistic approach to heart health here: https://www.evergreendoctors.com/heart

BACKGROUND: An association between sweetened beverages and several cardiometabolic diseases has been reported, but their association with atrial fibrillation (AF) is unclear. We aimed to investigate

18/04/2024

Sugar and cancer!

New groundbreaking research conducted by scientists from the National University of Singapore uncovered a profound link between poor diet, particularly conditions like diabetes and obesity, and heightened cancer risk.

Their study identifies methylglyoxal, a byproduct of glucose breakdown, as a chemical culprit that can inflict DNA damage, potentially paving the path to cancer initiation. This revelation challenges conventional wisdom, suggesting that repeated exposure to factors like poor diet can temporarily deactivate cancer-preventing genes, gradually escalating cancer risk over time.

Published in the esteemed journal Cell, this research not only illuminates the intricate mechanisms underlying cancer development but also underscores the critical role of diet and metabolic health in shaping our susceptibility to this devastating disease. The implications are staggering, urging a paradigm shift in our understanding of cancer prevention strategies.

The research team first studied patients who are at a high risk of developing breast or ovarian cancers because they inherit a faulty copy of the cancer gene – BRCA2 – from their parents. They demonstrated that cells from such patients were particularly sensitive to the effects of methylglyoxal, which is a chemical produced when our cells break down glucose to create energy. The study showed that this chemical can cause faults in our DNA that are early warning signs of cancer development.

The team’s research also suggested that people who do not inherit a faulty copy of BRCA2 but could experience higher-than-normal levels of methylglyoxal – such as patients with diabetes or pre-diabetes, which are connected with obesity or poor diet – can accumulate similar warning signs indicating a higher risk of developing cancer.

Prof Venkitaraman elaborated, “Our research suggests that patients with high methylglyoxal levels may have higher cancer risk. Methylglyoxal can be easily detected by a blood test for HbA1C, which could potentially be used as a marker. Furthermore, high methylglyoxal levels can usually be controlled with medicines and a good diet, creating avenues for proactive measures against the initiation of cancer.”

https://www.cell.com/cell/fulltext/S0092-8674(24)00255-1

At Evergreen Doctors we reverse diabetes naturally, and measure advanced blood markers that can reveal risk of metabolic problems 10 years before a fasting blood sugar test shows any abnormality. Find out more here: https://www.evergreendoctors.com/diabetes
We focus on the foundations of health, and seek to optimise your health in all ways.