Shimadzu Oceania

08/02/2021

There are a variety of phenolic compounds such as alkylphenols (AP), chlorophenols (CP), nitrophenols (NP),bisphenol A (BPA) and triclosan, etc. Phenols are widely used as chemical precursors in industries and for other purposes in agriculture, medical and domestic processes.
Many phenolic compounds are toxic and carcinogenic to human and they are classified as the priority pollutants in surface and drinking waters [1, 2]. The US Environmental Protection Agency (EPA) and the European Community (EC) have set a legal tolerance level of 0.5 µg/L for total phenols and 0.1 µg/L for individual phenolic compound in drinking water [3,4]. Japan’s MHLW (Ministry of Health, Labor and Welfare) has designated six phenols as the index of water quality standard requirements. Various analytical methods such as GC, GCMS, HPLC and LC/MS/MS have been used for detection and quantitation of phenols in drinking waters [5, 6]. These methods require sample pretreatments including derivatization and/or pre-concentration by SPE, etc. In this Application News, a MRM based method is described, which was developed for detection and quantitation of phenol and nine substituted phenols (see Table 2) in treated water and reservoir water on triple quadrupole LC/MS/MS with an APCI interface.
Here we developed a High Sensitivity Method for Determination of Ten Phenols on LC/MS/MS with APCI Interface
http://ow.ly/aI7C50Dh2lv

03/02/2021

Vitamins are essential micronutrients to maintain the normal functioning of organisms, but they must be ingested from food because they are not synthesized sufficiently in the body. Deficiencies of vitamins in the body cause symptoms such as disease and growth disorders. Vitamin A is associated with night blindness and skin abnormalities, vitamin D with rickets and osteomalacia, vitamin E with anemia and blood circulation disorders, and vitamin K with hemorrhaging, osteoporosis, etc. Therefore, it is very important to accurately analyze the fat-soluble vitamins in foods and supplements. The fat-soluble vitamins are broadly classified into vitamin A, vitamin D, vitamin E, and vitamin K according to their chemical structure and physiological effects. Due to the large number of isomers, good separation is required for fat-soluble vitamin analysis.
Here we introduce an example of a simultaneous analysis of fat-soluble vitamins using a supercritical fluid chromatograph (SFC) and triple quadrupole mass spectrometer for detection.
http://ow.ly/FplH50Dh2bB

31/01/2021

A Novel Cell Culture Media Analysis Platform for Culture Process Development
"Cell Culture Media Analysis Platform, C2MAP system”
Optimization and control of cell culture processes are essential to increase production efficiency of biopharmaceuticals. In the field of cell therapy including regenerative medicines, enhanced control of the culture process is also becoming important to reduce cell variability and improve consistency of mass production of the cells. Comprehensive monitoring of culture supernatant components gives researchers useful information for these purposes. However, current technologies for process monitoring are limited to measurement of pH, dissolving gases, and some small compounds such as glucose, glutamine, lactate, and ammonia in culture supernatant.
http://ow.ly/AqRO50Dh1Un

28/01/2021

Cetuximab is a human monoclonal antibody (mAb) for the treatment of metastatic colorectal carcinoma, head & neck cancer. Bioanalysis of mAb drugs is based on ligand binding assay, this technique has larger variability & longer assay, Here we look at rat plasma using nSMOL (nano surface molecular orientation limited proteolysis) reagent kit and LCMS-8060 triple quadrupole.
http://ow.ly/gG7r50Dh1FT

27/01/2021

Fighting Infectious Diseases with the Power of Science | Shimadzu Corporation
https://youtu.be/i903vviNU9g

Science is more important now than ever before. Since its inception in 1875, Shimadzu Corporation has been committed to contributing to society through scien...

26/01/2021

Extended release or sustained release dosage forms are designed to release a drug at predetermined rate in order to maintain a constant drug concentration for a specific period. Here we use our Nexrea FV for online dissolution of Metformin ER tablets.
http://ow.ly/AJZh50Dh180

24/03/2019

Custom build GC