29/07/2021
Oxidative DNA damage with Gay Wardle Education 💙
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DNA damage to both the mitochondria DNA and the cell DNA occurs with increased ROS. As ROS is a result of respiration from the mitochondria, it will be the mitochondria DNA that will be the first to deteriorate 🧬
Ultra violet radiation can also increase reactive oxygen species, when this happens there will be an effect on other cellular organelles as oxidative stress is increased, mitochondria DNA is mutated and further mutation occurs to the cells’ DNA.
When it comes to the skin, keratinocyte cells that have increased ROS also have a trypsin and heat–sensitive material that generates further ROS when exposed to UV radiation. Lipid peroxidation occurs because of elevated ROS to both cell membrane and mitochondria membrane. Inevitable senescence and cell apoptosis occur, causing pigment and vascular changes that contribute to aged skin.
We are all exposed to sources of oxidative damage, which affects our cells and can lead to damage, poor health, and disease if left unchecked. While low levels of ROS are needed for cell proliferation, regulation, signal transduction and gene expression, increased levels will cause mutation to DNA, therefore, increase the risk of ageing, as well as skin disease.
