31/08/2025
At Stepping Stones Therapy for Children, we work with many children and families affected by Paediatric Acute-Onset Neuropsychiatric Syndrome (PANS). We see first-hand the impact this condition can have on a child’s development, wellbeing, and daily life.
That’s why we are proud to share a major step forward. A new paper published in Molecular Psychiatry (part of the Nature group of journals) has, for the first time, identified a clear biological signature in children with PANS. This research confirms what families and clinicians have known for years: PANS is not “controversial” or “just behavioural.” It is a legitimate medical condition involving the immune system, genes, and brain development.
We are honoured that Stepping Stones was able to provide funding support for this study, alongside PANS Australia, which contributed funds raised at the national PANS conference. Together, these contributions helped make this important research possible.
We extend our thanks to Professor Russell Dale and his team at the Children’s Hospital at Westmead for their dedication to families and their leadership in advancing understanding of this condition.
This paper is a turning point. With early recognition and treatment, children with PANS can recover. But if diagnosis and treatment are delayed, the risks of long-term or even lifelong challenges increase significantly. It is vital that this evidence is shared with paediatricians, psychiatrists, neurologists and health professionals everywhere.
You can read the paper here: https://www.nature.com/articles/s41380-025-03127-5