14/08/2025
Managing complex conditions requires an individualised approach. A 45-year-old male presented with schizophrenia, MDD, ADHD, severe anxiety, paranoia, obesity, high blood pressure, and debilitating insomnia. The patient’s severe adverse reaction to methylated B vitamins, which amplified his anxiety and worsened his insomnia, was a key clinical clue.
This reaction suggested a disruption in his methylation pathway, a process vital for neurotransmitter production. This pointed to likely genetic variations, particularly in the MTHFR or COMT genes. His psychiatric profile further supported a COMT polymorphism, which slows the breakdown of dopamine and noradrenaline, causing saturation in the prefrontal cortex. This buildup contributes to anxiety, paranoia, and an overactive stress response that disrupts sleep.
Without genetic testing, a targeted nutraceutical protocol was implemented with two supplements. N-Acetyl Cysteine (NAC) was used to modulate excitatory glutamate and reduce oxidative stress,
restoring brain chemistry and improving sleep. MediHerb N-Regenex, a broad-spectrum potent anti inflammatory herbal formula, supported the brain, nervous system, and the HPA axis, providing a calming effect without over-stimulation. Coupled with dietary interventions targeted to restore eubiosis and reduce inflammation while providing saturated nutritional repletion.
This focused intervention led to remarkable improvements. His anxiety and paranoia decreased, his mood stabilised, and his insomnia resolved. The case demonstrates that a detailed clinical history can guide successful, personalised treatment plans without costly interventions.