30/09/2025
You age in three big, sudden waves.
A study analyzing more than 4,000 blood samples has revealed that our bodies actually age in three distinct shifts. These biological “gear changes” happen, on average, at 34, 60, and 78 years old.
You age in three big, sudden waves.
We tend to think of aging as a steady decline, a straight line from youth to old age. But new research suggests the process is far less linear.
A study analyzing more than 4,000 blood samples has revealed that our bodies actually age in three distinct shifts. These biological “gear changes” happen, on average, at 34, 60, and 78 years old.
Scientists discovered this by examining the proteome – the vast mix of proteins circulating in our blood plasma. Of the 3,000 proteins they tracked, about 1,379 changed significantly with age. But instead of shifting gradually, they spiked in dramatic waves.
The first wave comes in early adulthood (around 34), when clusters of proteins linked to development and metabolism suddenly change. The second wave hits at 60, tied to cardiovascular and brain health. The third arrives at 78, associated with frailty and age-related diseases.
This finding could transform how we track and even slow it. By analyzing 373 key proteins, scientists were able to predict a person’s biological age to within three years. In some cases, people whose “blood age” appeared younger than their actual age were indeed healthier than their peers.
The study also revealed that men and women age differently – nearly two-thirds of the shifting proteins were strongly sex-specific.
The next step? Doctors may one day be able to run a simple blood test to spot whether your heart, liver, or brain is aging faster than the rest of your body.
That could mean earlier warnings for diseases like Alzheimer’s or cardiovascular decline – and new strategies to extend not just lifespan, but healthspan.
Read the study:
“Undulating Changes in Human Plasma Proteome Profiles Across the Lifespan.” Nature Medicine, vol. 25, no. 12, Dec. 2019, pp. 1843–1850