15/03/2026
How does Rejuran work?
Here’s the mechanism and effects:
1. Injection into dermis
Rejuran is delivered by many tiny micro-injections into the superficial to mid-dermal layer.
2. Stimulation of fibroblasts
The polynucleotides act to “signal” skin cells (particularly fibroblasts) to increase production of collagen and elastin, which are key structural proteins in the dermal matrix.
3. Anti-inflammatory & repair effects
The PN fragments also help reduce skin inflammation, assist in healing microdamage or photodamage, and support the restoration of the skin barrier.
4. Scaffolding / matrix effect
This is where the idea of “scaffolding” comes in: the injected polynucleotides form a kind of biocompatible matrix or scaffold in the dermis. This scaffold provides structural support, creating a framework around which new collagen and elastin fibers can form and reorganise.
In short: you can think of the PN molecules as forming a temporary “sponge” or “sling” in the dermis that helps guide and support new tissue growth.
5. Gradual remodeling over weeks to months
Over time, as the skin remodels (with collagen/elastic fiber formation), the scaffold gradually degrades, leaving behind more resilient, better-structured skin.
