23/05/2026
At the 2026 Australasian Skin Cancer Congress in Brisbane this weekend A/Prof Alexander van Akkooi, melanoma surgical oncologist and MIA faculty member, delivered a presentation titled ‘Update on the Role of Sentinel Node Biopsy and MSLT-3’.
Melanoma surgery has evolved over time. One significant change has been Sentinel Lymph Node Biopsy (SLNB), which replaced the much more invasive Elective Lymph Node Dissection (ELND) for patients with early-stage melanoma.
SLNB is used to check whether melanoma has spread to selected nearby lymph node(s). This helps doctors more accurately stage the cancer and identify patients who may benefit from additional therapies. SLNB plays an important role in guiding treatment decisions.
For patients with more advanced Stage III melanoma, treatment is also evolving. The MSLT-3 clinical trial is currently investigating whether less extensive surgery can be safely performed after neoadjuvant (pre-surgery) therapy. The trial is comparing standard Therapeutic Lymph Node Dissection (TLND) with a less invasive approach that removes only the affected “index” lymph node. The aim is to reduce the impact of surgery while maintaining excellent outcomes.