Molecular Modeling and Drug Design Laboratory, BCSIR Chittagong

12/07/2021

গত ২৮ শে জুন থেকে কোভিড মহামারি নিয়ন্ত্রণে সরকার কঠোর বিধিনিষেধ আরোপ করেন, যা আগামী ১৪ ই জুলাই পর্যন্ত চলমান থাকবে। যেহেতু, এই বিধিনিষেধ এর আওতায় যানবাহন চলাচলে নিষেধাজ্ঞা ছিল তাই আমরা আমাদের ট্রেইনিং স্তগিত রেখেছি।
যদি দ্রুত যানবাহন চলাচল স্বাভাবিক হয় তাহলে আমরা শারীরিকভাবে আমাদের ল্যাবে ট্রেইনিং আয়োজন করব। সেক্ষেত্রে, যারা ইতিমধ্যে এপ্লাই করেছেন তাদের ফোন এবং মেইলে জানানো হবে। আমাদের পরবর্তী সিদ্ধান্ত জানার জন্য চোখ রাখুন আমাদের ফেইসবুক পেইজ এবং ওয়েব সাইটে। ধন্যবাদ সবাইকে।

25/06/2021

Basic Training on Structure Based Drug Design. For details, please visit https://cutt.ly/ln7Cccm

24/06/2021

Basic Training on Structure-Based Drug Design (11-13 July 2021).
(Training link: https://cutt.ly/ln7Cccm)

Your registration fee will cover-

 3 days long physical hands-on training.

 15+ software installation on your laptop.

 A unique identifier (ID) for the trainees. We keep and publish all trainee lists on our website (https://mmddl-ctgbcsir.gov.bd/), which you may access using this ID and use as proof of attendance in this training.

 After the training, a printed copy of the certificate will be issued, and an online copy will be published on our website, which may be accessed & downloaded at any time by trainee ID.

 Lunch, as well as tea and snack, will be provided.

Important Notes:

 Only 15 trainees will be allowed, and those who are interested in participating in a post-training project will be given priority.

 Fill out the Google form (https://cutt.ly/Cn8AlNQ) and let us know you are interested.

 We will look over your Google form and call or email you to let you know if you have been accepted (with a payment method).

 Finally, after receiving confirmation, pay the registration fee of 3600Tk.

Notice 2: We have already received a large number of applications, and after examining them, an acceptance email will be delivered on June 28th.

23/06/2021

Contents we will cover in this training (11-13 July 2021).

1. Basic concept: Lecture on the Basic concept of Computer-Aided Drug Design and discovery. Concept of traditional vs rational drug design.

2. Virtual Ligand Preparation: Chemical structure drawing by ChemDraw 16.0 software, structure & structure related data mining from ChemDraw & different database.

3. Ligand Optimization: Lecture on Quantum Mechanics in Drug Design, DFT Theory, HF theory, Basis Set. Ligand optimization by Gaussian software and optimized data analysis.

4. Ligand drug ability prediction: Molecular properties analysis, ADME analysis, drug likeliness test, toxicity and target prediction by different webserver and tools. Library building for virtual screening.

5. Homology Modeling: Introduction on different protein database i.e., Uniprot & PDB. Homology modelling ex*****on by Easy modeller 4.0 and online webserver. Model refinement, validation, and analysis.

6. Protein selection & preparation: Introduction to Protein, different Structures of Proteins, DNA & RNA. Discussion on target protein selection based on a disease. Protein selection for molecular docking, cleaning, and optimization & energy minimization by different tools.

7. Molecular docking: Basic concept of molecular docking, types of docking, different renowned paid & free tools for molecular docking. Ligand preparation, protein preparation, grid generation & ex*****on. Non-bond interaction analysis to know active amino acids & their bond distance.

8. Molecular dynamic simulation: Introduction to MD simulation & different software used for MD simulation. Discussion on different features of MD simulation.

9. Manuscript preparation: Discussion on manuscript preparation i.e., Types of articles, Skeleton building, tips for writing different section of article, figure & table preparation. Discussion on manuscript submission & revision I.e., Journal selection, pre-submission checklist, cover letter, graphical abstract preparation & rebuttal letter preparation.

10. Closing session: Discussion on research facility at BCSIR Laboratories Chattogram and student applying procedure. Discussion on higher study preparation.

 Basic Training on Structure-Based Drug Design (11-13 July 2021).
 Only 15 trainees will be allowed, and those who are interested in participating in a post-training project will be given priority.
 Fill out the Google form (https://cutt.ly/Cn8AlNQ) and let us know you are interested.
 We will look over your Google form and call or email you to let you know if you have been accepted (with a payment method).
 Finally, after receiving confirmation, pay the registration fee of 3600Tk.

23/06/2021

 Basic Training on Structure-Based Drug Design (11-13 July 2021).
 Only 15 trainees will be allowed, and those who are interested in participating in a post-training project will be given priority.
 Fill out the Google form (https://cutt.ly/Cn8AlNQ) and let us know you are interested.
 We will look over your Google form and call or email you to let you know if you have been accepted (with detailed payment method).
 Finally, after receiving confirmation, pay the registration fee of 3600Tk.

22/06/2021

That is fantastic news! MMDDL laboratories chattogram arranging basic training on structure-based drug design after a long period. Due to the COVID-19 problem, we are only allowing 15 trainees this time. The event will take place from July 11 to 13, 2021, and will last three days. The software installation will take place on July 10th, as it has in the past. To join our training, simply complete the google form with the essential details. Do not pay first! Please wait for our confirmation email; we will notify you of your acceptance via phone and email.

Google form link: https://docs.google.com/forms/d/15fF8FpxP7P_byVj5X6sEwdgUJQSljPrvmd09s1Bg4SU/edit

Registration fee: 3600Tk (Payable after acceptance email)

The Molecular Modeling, Drug-Design and Discovery Laboratory, Pharmacology Research Division, BCSIR Laboratories Chattogram will provide a basic training on structure-based drug design.

20/06/2021

This is one of the reviews from MMDDL's research student.

Article Title: Adhatoda vasica (Nees.): A review on its botany, traditional uses, phytochemistry, pharmacological activities and toxicity.
Article type: Review article.
Journal Name: Mini-Reviews in Medicinal Chemistry.
Impact factor: 2.733
First author: Tahmida Shamsuddin (B. Sc. in Applied Chem., CU)
Article link: https://www.eurekaselect.com/191871/article

Background: Adhatoda vasica (Nees.) of family Acanthaceae has been used in the Southeast tropical zone as it is efficacious against headache, colds, cough,...