Medi made easy

30/06/2022

26/06/2022

28/03/2022

IgG is the only antibody that crosses the placenta and enters the fetal circulation.

24/03/2022

Pushpa 😂

23/03/2022

Visual representation of the menstrual cycle.😅

23/03/2022

Stop codons 😌

23/03/2022

Germ layers derivatives

23/03/2022

Type 1 vs Type 2 Diabetes mellitus

23/03/2022

👍Montelukast

A very common drug used in the treatment of asthma ,allergic rhinitis and bronchospasms.

👉How does it work?

Montelukast is a leukotriene receptor antagonist.
It blocks the effects of leukotrienes in the airways.

👉Now what is leukotriene and what is its effects ?

Leukotrienes are eicosanoid (20 Carbon polyunsaturated fatty acid) derivatives .They are mainly derived from Arachidonic acid (a 20 Carbon polyunsaturated fatty acid).

Arachidonic acid is stored in membrane phospholipids and when our body comes in contact with an allergic substance, the membrane phospholipids release arachidonic acid which then undergoes two pathways ---- 1. Cyclo-oxygenase pathway, 2.Lipoxygenase pathway.

Leukotrienes are synthesised via the lipoxygenase pathway.

Leukotrienes initiate a number of inflammatory responses and also cause tightening of airway muscles and the production of excess mucus and fluid .Besides , leukotrienes are powerful bronchoconstrictors and they also increase vascular permeability, promoting further inflammation.

As a result , a person may experience asthma attacks associated with bronchospasms.

👍Well, montelukast prevents the leukotrienes from exerting these effects and help to ease the symptoms of asthma, bronchospasms and allergic rhinitis.

23/03/2022

👉Comet / Metfo / Glucomet / Nobesit

These medicines are very common in every household now-a-days.
All these are actually the same medicines but are manufactured by different pharmaceutical companies.

👉The medicines belong to the generic or group -- * Metformin*

👉Metformin belongs to a class of drugs called * Biguanides*.

👍Biguanides are commonly used in the treatment of Diabetes mellitus (especially type 2 diabetes) .

👉 How does biguanides lower blood glucose levels?

Metformin has anti-hyperglycaemic effects. It lowers blood glucose levels by ---

1) By decreasing hepatic glucose production by inhibiting gluconeogenesis ( synthesis of glucose from non-carbohydrate sources) .

It also inhibits glycogenolysis ( breakdown of glycogen yo release glucose)

2) By delaying intestinal absorption of glucose.

3) By enhancing insulin sensitivity by increasing by increasing peripheral glucose uptake and utilisation.

Besides, METFORMIN is also used in the treatment of Polycystic Ovarian Syndrome (PCOS).😊