
07/16/2025
Wilkie's syndrome, also known as Superior Mesenteric Artery (SMA) Syndrome, is a rare condition characterized by the compression of the third portion of the duodenum (the first part of the small intestine) between the superior mesenteric artery and the abdominal aorta. This compression leads to partial or complete obstruction of the duodenum, causing a range of gastrointestinal symptoms. The condition is often associated with a reduced aortomesenteric angle (typically 6–25° compared to the normal 38–56°) and a narrowed aortomesenteric distance (2–8 mm compared to the normal 10–20 mm), primarily due to a loss of the mesenteric fat pad that normally cushions the duodenum.
# Surgical intervention:
Indicated when conservative measures fail, symptoms are severe, or complications (e.g., duodenal stasis, perforation) arise.
Common procedures include:
-Duodenojejunostomy: The most common and effective surgical option, with a success rate of around 90%, involving an anastomosis between the duodenum and jejunum to bypass the obstruction. It can be performed laparoscopically.
-Strong’s procedure: Sectioning the ligament of Treitz to relocate the duodenojejunal junction, though it has a higher failure rate and is typically used in infants.
-Gastrojejunostomy: An alternative but less preferred due to the risk of peptic ulceration.
Here is a postoperative OED image of a patient for whom I performed a Duodenojejunostomy. Very good postoperative outcomes with significant improvement of the symptoms.