H2020 Restore Project

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H2020 Restore is a joint European initiative to find a cure for MS

Mission statement

In this project, researchers and clinicians from Belgium, Spain, the Netherlands and Germany have joined efforts in an attempt to find a cure for multiple sclerosis (MS), a condition that affects the brain and spinal cord. Approximately one in every thousand people are diagnosed with the disease in Europe, mostly in their 20s, 30s and 40s. Although there are many options available for treating and managing MS today, a cure is still lacking. Restore will test a new therapeutic approach based on patients’ own cells. This cell therapy, a type of personalised medicine, is currently being lined up for an initial Phase 1 study in patients with MS. The researchers have developed what are known as ‘tolerance-inducing’ or tolerogenic dendritic cells (tolDC) – a special category of immune cells that function as the immune system’s master switch. In MS, the immune system has derailed, setting a cascade of processes in motion that ultimately results in damage to the body’s own cells and molecules. After being treated with vitamin D in a laboratory, tolDC are re-administered to the patient and are then able to re-educate the patient’s immune system, interfering directly with the underlying disease processes. Investigating the safety and feasibility of the vaccine will be a crucial step in the development of novel treatment strategies for MS. In order to perform this clinical trial, the researchers received support from the European Union’s Horizon 2020 research and innovation programme, enabling collaboration among several EU research institutes and companies.

http://www.h2020restore.eu/