Lab of Cancer Signaling - Uliège

Lab of Cancer Signaling - Uliège Our lab aims to better understand the molecular mechanisms underlying cancer development and resistance to therapy. CURECANCER@GIGA

🤩 Unique experience for our lab at ESPCR2024 meeting! Brilliant talk by Najla El Hachem, PhD presenting her beautiful pa...
17/10/2024

🤩 Unique experience for our lab at ESPCR2024 meeting!

Brilliant talk by Najla El Hachem, PhD presenting her beautiful paper on Valine-tRNA aminoacylation in resitant melanoma https://lnkd.in/eaRSkCTq . Bravo Najla! You make us proud 😉

A perfect intro to my own talk just after...
I was given the opportunity to present our work and our vision on the role of tRNA modifications in cancer phenotypes. Pierre Close

A truly enjoyable scientific moment 🤩 & a great publicity for in GIGA ULiège Fondation contre le Cancer ULiège Recherche & Innovation Research Institute FNRS Fondation Léon Fredericq, Fondation Hospitalo-Universitaire à Liège

Thanks to for the invitation and the beautiful meeting
https://lnkd.in/exVxmt-f

I was truly honoured to be invited at MDAnderson Cancer Center Texas to share our latest science with friends & collabor...
12/10/2024

I was truly honoured to be invited at MDAnderson Cancer Center Texas to share our latest science with friends & collaborators. A full day of intense scientific discussions with insightful perpectives on the crucial role of tRNA modifications in cancer, particularly their potential clinical implications. It's a talk & a day I will definitely remember!
MD Anderson Cancer Center
GIGA ULiège
ULiège Recherche & Innovation
Fondation contre le Cancer

I am particularly delighted to share our last discovery highlighting the key role of tRNA regulation (VARS) in the resis...
08/06/2024

I am particularly delighted to share our last discovery highlighting the key role of tRNA regulation (VARS) in the resistance of melanoma to targeted therapies.
👉 https://www.giga.uliege.be/cms/c_12703258/en/transfer-rnas-at-the-heart-of-therapeutic-resistance

Special congrats to Najla El Hachem (Najla Lhm) who brilliantly led the work.

Special thanks to the team, to our exceptional collaborators and to our sponsors who support our research FNRS -Research Institute Fondation contre le Cancer Fondation Léon Fredericq, Fondation Hospitalo-Universitaire à Liège

Check the News&Views written by Sohail Tavazoie, who nicely summarizes our discovery (Thank you !)
https://www.nature.com/articles/s41556-024-01430-x

Access to the full paper Cell Biology:
https://www.nature.com/articles/s41556-024-01439-2

University of Liège researchers discover a new therapeutic target for the treatment of melanoma resistant to targeted therapies.

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GIGA-Institute, CHU
Liège
4000

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+3243662923

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Laboratory of Cancer Signaling

Our lab aims to better understand the molecular mechanisms underlying cancer development and resistance to therapy. We wish to define innovative therapeutic opportunities for future cancer treatment.

In particular, we believe that selective, codon-specific, mRNA translation may drive tumor cells adaptation and may represent a new vulnerability of cancer cells. Therefore, using a combination of mouse models and patients derived material, we study the role of tRNA biology and specific codon decoding in the reprogramming of mRNA translation taking place during cancer development and therapy resistance. CURECANCER@LCS