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IMMUcan, Petit Bruxelles (2026)

15/04/2026

A bioRxiv preprint introduces Cellohood, a new computational framework for identifying cellular neighbourhoods, developed and validated using IMMUcan imaging datasets.

The study shows how large, harmonised spatial datasets enable reproducible, interpretable discovery of tumour microenvironment organisation using advanced computational approaches.

📄 Read the preprint:
https://www.biorxiv.org/content/10.1101/2025.11.10.687184v1

IMMUcan biosamples and data are designed to support exactly this kind of innovative, cross-disciplinary research.

👉 Learn how to collaborate: https://immucan.eu/how-to-collaborate

09/03/2026

IMMUcan data powering advances in cancer research methods.

A 2025 Cell Reports Methods publication presents scalable, reproducible multi-modal imaging and analysis workflows developed and validated using IMMUcan cancer tissue data.

The study highlights how access to standardised, high-quality samples at scale enables not only biological discovery, but also the development of robust, open-source analytical methods for the wider community.

Read the paper:
https://www.cell.com/cell-reports-methods/fulltext/S2667-2375(25)00206-1

With IMMUcan biosamples now accessible to external researchers, similar method-driven innovation is within reach.

Explore access: https://immucan.eu/how-to-collaborate

17/02/2026

IMMUcan data have already contributed to peer-reviewed, high-impact research, including a 2024 publication in Immunity, one of the leading journals in immunology.

The study explores how CD4⁺ T cell activation distinguishes patient responses to combined PD-L1 and CTLA-4 blockade in head and neck cancer, advancing our understanding of immune mechanisms underlying immunotherapy response.

This work illustrates what becomes possible when deeply annotated human biosamples are combined with rigorous molecular and clinical data.

Read the paper:
https://www.cell.com/immunity/fulltext/S1074-7613(24)00083-9

If your next research depends on robust, trial-grade oncology samples, IMMUcan is open for collaboration.
Explore sample availability & submit a proposal: https://immucan.eu/how-to-collaborate

03/02/2026

High-impact cancer research starts with access to the right samples.

Over the past years, IMMUcan data and biosamples have supported research published in leading journals such as Cancer Research, Immunity, and Cell Reports Methods -, advancing our understanding of tumour–immune interactions, spatial biology, and translational biomarkers.

IMMUcan has opened access to its oncology biosample collection from ~1,400 patients, covering major cancer cohorts including:
▪ Non-small-cell lung cancer (NSCLC)
▪ Renal cell carcinoma (RCC)
▪ Colorectal cancer (CRC)
▪ Triple-negative & HER2+ breast cancer
▪ Head & neck cancer

Available materials include FFPE tumour tissue, tumor and germline DNA/RNA, PBMCs, and plasma/serum suitable for cfDNA analyses, all paired with rich molecular and clinical data and maintained at trial-grade quality with centralised QC.

This is an opportunity for researchers to build on proven, high-impact foundations and accelerate discovery without starting sample collection from scratch.

Explore sample availability and submit your proposal:
https://immucan.eu/how-to-collaborate

09/01/2026

High-quality data drives high-impact discoveries — and IMMUcan is opening the door to one of the largest, most extensively profiled oncology sample collections available.

Researchers can now request access to biosamples from ~1,400 patients across major cancer cohorts, including NSCLC, RCC, CRC, TNBC, HER2+ BC, and head & neck cancer. Available materials range from FFPE blocks and slides to tumor DNA/RNA, germline DNA, PBMCs, and plasma/serum suitable for cfDNA analyses.

All samples come with robust molecular and clinical data, offering a powerful foundation for biomarker discovery, immune profiling, and integrative multi-omics research. Trial-grade quality and centralised QC ensure consistency and reliability.

If you're developing your next analysis or exploring new hypotheses in cancer immunology, this is an opportunity worth acting on.

👉 Explore availability and submit your proposal: https://immucan.eu/how-to-collaborate/

All requests undergo scientific and feasibility review.

19/12/2025

As 2025 comes to a close, we look back with gratitude on the progress IMMUcan has made through the years: from advancing multi-omics data generation to deepening our understanding of the tumour microenvironment, together with an outstanding community of partners.

Thank you to all patients, clinicians, researchers, and collaborators whose commitment continues to make this initiative possible.

We wish you a restful holiday season and a new year filled with health, discovery, and collaboration.

✨ Happy Holidays from the IMMUcan team! ✨

18/12/2025

🔬 IMMUcan at ESMO Immuno-Oncology 2025 | Poster Highlight II

The second IMMUcan poster featured at presented real-world data from the IMMUcan early-stage TNBC cohort. The research focusing on patients treated with neoadjuvant chemo-(immuno) therapy was presented by Camille Goudemant from Institut Jules Bordet.

Over a 5-year period, the team observed:
✅ Evolving neoadjuvant TNBC practices across Europe
✅ Decreasing anthracycline use and increasing use of carboplatin and immunotherapy
✅ Improving pCR rates over time, highest with KEYNOTE-522–like regimens and in tumors with high TIL levels

While survival data are not yet available, surrogate markers such as pCR and TILs provide valuable insights into treatment effectiveness in real-world settings. These data support the feasibility and effectiveness of neoadjuvant chemo-immunotherapy in early TNBC across Europe.

IMMUcan highlights the power of collaborative, data-sharing initiatives that combine clinical outcomes with deep molecular and immune profiling. Ongoing multi-omics analyses will further refine our understanding of TNBC biology and treatment response.

👉 Learn more: www.immucan.eu

16/12/2025

🔬 IMMUcan at ESMO Immuno-Oncology 2025 | Poster Highlight 1

Last week, IMMUcan was featured at with two poster presentations. For the first poster, researchers from the IMMUcan team presented results from a comprehensive multi-omics analysis of advanced TNBC patients treated with chemo-immunotherapy in the SYNERGY trial and EORTC-1553-SPECTA.

While immune checkpoint inhibitors have improved outcomes in TNBC, most patients eventually develop resistance. Beyond PD-L1, predictive biomarkers remain limited, and how tumors adapt early during treatment is still poorly understood.

By integrating bulk and single-cell RNA-seq, whole-exome sequencing, spatial and imaging technologies, the study identified:
▪️ Distinct immune and molecular profiles associated with treatment outcomes at baseline
▪️ Better outcomes linked to immune-enriched, proliferative tumors with higher CD8⁺ T cells, Tregs and plasma cells
▪️ Poor prognosis associated with angiogenic, fibrotic, immune-excluded tumor microenvironments and PIK3CA pathway alterations
▪️ Early on-treatment dynamics showing PD-L1 downregulation on tumor cells, macrophage infiltration and a TGFB1/IL-10-driven immunosuppressive milieu

Resistance to chemo-immunotherapy appears to involve a fibro-vascular reprogramming of the tumor microenvironment, opening the door to new TME-based biomarkers and therapeutic targets to be tested in future clinical trials.

👏 Congratulations to the authors and to all collaborators across academia, hospitals, research institutes and industry who made this work possible.

Elisa Agostinetto | Nicolaas Van Renne | Andrea Joaquín García | Marie Morfouace | Marcin Możejko | Zoë Denis | Henoch Hong, David Venet | Robin Liechti, Stephanie Tissot-Renaud | Mattia Rediti | Xavier Catteau | Daniel Schulz | Delphine LOIRAT | Philippe Aftimos MD | Emanuela Romano| Hans Wildiers | Ewa Szczurek | Christos Sotiriou | Laurence Buisseret

20/11/2025

Cellohood represents a meaningful step forward for a better understanding of tumor–immune interactions. Its ability to capture full molecular details, operate across different levels of granularity, and connect spatial patterns with clinical outcomes makes it a powerful addition to how we study complex tissues within the consortium.

It’s also great to see this work now out as a preprint, as it represents an important milestone that highlights both the quality of the science and the collaborative effort behind it. Making these methods publicly available will help broaden the impact and support progress across the spatial biology community.

Congratulations to all authors from our partner institutions across Europe. This is a fantastic achievement that perfectly reflects the collaborative spirit of IMMUcan.

Read the pre-print: https://www.biorxiv.org/content/10.1101/2025.11.10.687184v1

03/11/2025

Last week, the IMMUcan consortium met at EORTC in Brussels for two days of inspiring discussions and collaborative data exploration (27–28 October 2025).

Our incredible IMMUcan team — researchers, clinicians, and data scientists from across Europe — came together to share results, challenge ideas, and set the next steps in understanding the tumour microenvironment and the immune response across cancer types. The meeting was a true showcase of the passion, expertise, and teamwork driving IMMUcan forward.

Over the two days, participants explored:

New data from molecular, cellular, and clinical analyses, including spatial transcriptomics, proteomics, and plasma profiling.

Cohort updates across breast, colorectal, renal, lung, and head and neck cancers, highlighting progress from deep profiling and imaging studies.

Multi-modal data integration approaches linking spatial and bulk omics to identify pan-cancer spatial domains and accelerate insights into cancer-immune interactions.

The discussions reinforced what makes IMMUcan unique: a community of experts united by a shared mission to translate complex data into meaningful advances for patients.

A big thank you to all the teams, coordinators, and contributors for their dedication and brilliance. 🔬

24/10/2025

Science is a team effort!

IMMUcan wouldn’t be possible without the collaboration of clinicians, researchers, data scientists, and patients across Europe.

By pooling expertise, we’ve built one of the largest tumour–immune profiling efforts to date. Together, we are:

✅Standardising and curating data across multiple cancer types
✅Building a sustainable platform for future research
✅ Translating findings into evidence that supports better patient outcomes

Every partner adds a piece to the puzzle. Working together is the only way to turn complex biology into real-world impact.

Learn more about our consortium: immucan.eu

10/10/2025

What is spatial transcriptomics, and why does IMMUcan use it?

Traditional sequencing tells us what genes are expressed, but not where. Spatial transcriptomics adds this missing layer by mapping gene activity in its original tissue context.

In IMMUcan, this means we can:

➡️See where immune cells and tumour cells “talk” to each other
➡️Identify hotspots of resistance or immune evasion
➡️Link spatial patterns to treatment response

It’s like turning a static snapshot into a living map of the tumour microenvironment.

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