18/05/2020
Os estudos em que se baseiam os prescritores de Cloroquina e Hidroxicloroquina são chineses (como confiar?) e Franceses (nº mínimo de pacientes).
Quando a pandemia chegou a Inglaterra e EUA criaram-se protocolos observacionais sérios e com milhares de pacientes. O melhor deles e mais recente publicado no New England Jornal of Medicine dia 7 de maio (que também publicou os trabalhos chineses e franceses) registra a experiência em 1446 pacientes e conclui que não serve para nada. De lá para cá e até antes desse, só que com um menor número de indivíduos) já foram publicados outros trabalhos mostrando a pouca evidência de que esses medicamentos tenham alguma ação sobre alguma das fases da COVID19
Segue o resumo do estudo e se alguém quiser ler ele inteiro posso enviar.
Também é importante ver quem escreveu e a que instituição eles pertencem
No final do texto na versão completa eles fazem uma menção que demonstra a seriedade dos pesquisadores envolvidos
Supported in part by grants (RO1-LM006910, RO1-HL077612, RO1-HL093081, and RO1-HL121270) from the National Institutes of Health.
Disclosure forms provided by the authors are available with the full text of this article at NEJM.org.
We acknowledge the dedication, commitment, and sacrifice of the staff, providers, and personnel in our institution through
the Covid-19 crisis and the suffering and loss of our patients as well as in their families and our community.
Observational Study of Hydroxychloroquine in Hospitalized Patients with Covid-19
From the Divisions of General Medicine, Infectious Diseases, and Pulmonary, Allergy, and Critical Care Medicine, Department
of Medicine (J.G., J.Z., M.B., A.L., D.M., C.K., R.G.B., M.E.S., N.W.S.), the Departments of Biostatistics (Y.S.) and Epidemiology ( J.P., R.G.B., N.W.S.), Mailman School of Public Health, and the Department of Biomedical Informatics (G.H.), Vagelos College of Physicians and Surgeons, Columbia University, and New York–Presbyterian Hospital–Columbia University Irving Medical Center (J.G., J.Z.,M.B., A.L., D.M., C.K.,R.G.B., M.E.S., N.W.S.) — all in New York. Address reprint requests to Dr. Schluger at the Division of Pulmonary, Allergy, and Critical Care Medicine, Columbia University Irving Medical Center, PH-8 E., Rm. 101,
622 W. 168th St., New York, NY 10032, or at ns311@cumc.columbia.edu.
This article was published on May 7, 2020,
at NEJM.org.
DOI: 10.1056/NEJMoa2012410
Copyright ©️ 2020 Massachusetts Medical Society.
BACKGROUND
Hydroxychloroquine has been widely administered to patients with Covid-19 without robust evidence supporting its use.
METHODS
We examined the association between hydroxychloroquine use and intubation or death at a large medical center in New York City. Data were obtained regarding consecutive patients hospitalized with Covid-19, excluding those who were intubated, died, or discharged within 24 hours after presentation to the emergency department (study baseline). The primary end point was a composite of intubation or death in a time-to-event analysis. We compared outcomes in patients ho received hydroxychloroquine with those in patients who did not, using a multivariable Cox model with inverse probability weighting according to the propensity score.
RESULTS
Of 1446 consecutive patients, 70 patients were intubated, died, or discharged within 24 hours after presentation and were excluded from the analysis. Of the remaining 1376 patients, during a median follow-up of 22.5 days, 811 (58.9%) received hydroxychloroquine (600 mg twice on day 1, then 400 mg daily for a median of 5 days); 45.8% of the patients were treated within 24 hours after presentation to the emergency department, and 85.9% within 48 hours. Hydroxychloroquine-treated patients were more severely ill at baseline than those who did not receive hydroxychloroquine (median ratio of partial pressure of arterial oxygen to the fraction of inspired oxygen, 223 vs. 360). Overall, 346 patients (25.1%) had a primary and-point event (180 patients were intubated, of whom 66 subsequently died, and 166 died without intubation). In the main analysis, there was no significant association between hydroxychloroquine use and intubation or death (hazard ratio, 1.04, 95% confidence interval, 0.82 to 1.32). Results were similar in multiple sensitivity analyses.
CONCLUSIONS
In this observational study involving patients with Covid-19 who had been admitted to the hospital, hydroxychloroquine administration was not associated with either a greatly lowered or an increased risk of the composite end point of intubation or death. Randomized, controlled trials of hydroxychloroquine in patients with Covid-19 are needed. (Funded by the National Institutes of Health.)