30/12/2022
A complete hydatidiform mole (CHM) is a type of molar pregnancy and falls at the benign end of the spectrum of gestational trophoblastic disease.
In 90% of cases, complete hydatidiform mole (CHM) arises when an empty o**m that lost its maternal chromosomes is fertilized by one s***m, which then duplicates its own DNA, resulting in a “complete” 46-chromosome set.
In 15-20% of the cases, complete hydatidiform mole may result in gestational trophoblastic neoplasia, with invasive mole being the most common form of persistent of gestational trophoblastic disease.
Clinically, patients with complete hydatidiform mole are often diagnosed early in gestation and are often asymptomatic at the time of diagnosis. Common presenting symptoms include vaginal bleeding, usually at 6–16 weeks gestation, large-for- date uterine size, and hyperemesis. CHM are commonly associated with a markedly elevated β-hCG level.
📝ULTRASOUND FINDINGS OF COMPLETE HYDATIDIFORM MOLE
US remains the imaging modality of choice for initial evaluation of molar pregnancy. These tumors may be incidentally discovered in asymptomatic patients undergoing routine first-trimester US or patients with clinically suspected molar pregnancy who present with vaginal bleeding or β-hCG titers higher than expected for gestational age.
The remarkable ultrasound features of CHM during the first trimester is an enlarged uterus filled with a heterogeneous predominantly echogenic mass with several cystic spaces. This is described as the “cluster of grapes” appearance and is due to hydropic chorionic villi.
It’s important to highlight that in complete mole fetal parts are absent. Another findings as multiple large, bilateral, functional ovarian cysts called theca lutein cysts are seen in less than 20% of cases of CHM.
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