Pernicious Anaemia/B12 Deficiency Support Group - Page

12/19/2025

12/08/2025

Impaired vibration means you cannot feel a tuning fork when the doctor is checking reflexes. A neurologist usually does this kind of test.

12/07/2025

An early diagnosis is crucial. Symptoms are less severe which decreases the risk of causing permanent damage. Recovery is faster. These are just some of the symptoms. There are many more symptoms

12/05/2025

Wouldn’t it be nice if every doctor would consider symptoms along with blood test results and place as much emphasis on symptoms as they do on test results. Some doctors get it and others do not.

Link to article

https://www.bmj.com/content/383/bmj-2022-071725

11/28/2025

This page isn't always about B12. Sometimes it helps to read stories to give our mind a break from the everyday stress of life.

If anyone is interested to follow this "Canadian Adventurer" who set out from Point Pelee, Ontario, on a homemade houseboat that resembles a raft, join the group at the link below. This houseboat is a federally registered vessel and meets all safety requirements, having onboard, a rubber dingy powered by an outboard motor, a John Boat and a Jetski. The Captain is an engineer and used his skills to build this houseboat. He is presently docked at Port Sanilac, Michigan and hopes to make Chicago by Christmas. Eventually, he will be trying to sail from Chicago to Madagascar Africa, by way of the Mississippi River, Gulf of Mexico, Mexico and then Madagascar. Spread out over a few years as he said he travels at his pace with no timetable to follow.
There is a lot of skepticism that he has left it too late in the season to traverse the Great Lakes, especially in November, a month that is known for having Gales. Wednesday's storm was very typical of a November gale.
People are watching for him and reporting his whereabouts when they sight the houseboat. Captain Steve does not have any social media accounts and doesn't even want his last name known, although does provide it when asked. He has said he will not document his journey but has given his approval to the facebook group to follow him.
I hope he proves all the naysayers wrong and makes it to Chicago by Christmas. I know I will be following to see if he does.

https://www.facebook.com/groups/1266236445553939

Send a message to learn more

11/24/2025

(How Adeonsylcobalamin may decrease the risk of developing Parkinsons Disease)

Vitamin B12 modulates Parkinson’s disease LRRK2 kinase activity through allosteric regulation and confers neuroprotection

Abstract
Missense mutations in Leucine-Rich Repeat Kinase 2 (LRRK2) cause the majority of familial and some sporadic forms of Parkinson's disease (PD). The hyperactivity of LRRK2 kinase induced by the pathogenic mutations underlies neurotoxicity, promoting the development of LRRK2 kinase inhibitors as therapeutics. Many potent and specific small-molecule LRRK2 inhibitors have been reported with promise. However, nearly all inhibitors are ATP competitive-some with unwanted side effects and unclear clinical outcome-alternative types of LRRK2 inhibitors are lacking. Herein we identify 5'-deoxyadenosylcobalamin (AdoCbl), a physiological form of the essential micronutrient vitamin B12 as a mixed-type allosteric inhibitor of LRRK2 kinase activity. Multiple assays show that AdoCbl directly binds LRRK2, leading to the alterations of protein conformation and ATP binding in LRRK2. STD-NMR analysis of a LRRK2 homologous kinase reveals the contact sites in AdoCbl that interface with the kinase domain. Furthermore, we provide evidence that AdoCbl modulates LRRK2 activity through disrupting LRRK2 dimerization. Treatment with AdoCbl inhibits LRRK2 kinase activity in cultured cells and brain tissue, and prevents neurotoxicity in cultured primary rodent neurons as well as in transgenic C. elegans and D. melanogaster expressing LRRK2 disease variants. Finally, AdoCbl alleviates deficits in dopamine release sustainability caused by LRRK2 disease variants in mouse models. Our study uncovers vitamin B12 as a novel class of LRRK2 kinase modulator with a distinct mechanism, which can be harnessed to develop new LRRK2-based PD therapeutics in the future.
https://pubmed.ncbi.nlm.nih.gov/30858560/

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Notes: PK
Allosteric regulation is a mechanism that modifies the activity of a protein by binding a molecule to a site other than the active site, causing a conformational change that either enhances or inhibits its function.
In Parkinson’s disease, Adenosylcobalamin inhibits the RRK2 kinase activity in cultured cells and brain tissue, and prevents neurotoxicity in cultured primary rodent neurons as well as in transgenic C. elegans and D. melanogaster expressing LRRK2 disease variants. The study uncovers vitamin B12 as a novel class of LRRK2 kinase modulator with a distinct mechanism, which can be harnessed to develop new LRRK2-based PD therapeutics in the future.

LRRK2-based therapeutics for Parkinson's disease (PD) primarily focus on developing kinase inhibitors to reduce the hyperactive LRRK2 protein, which is a major cause of both familial and idiopathic forms of PD.

Pat Kornic

Missense mutations in Leucine-Rich Repeat Kinase 2 (LRRK2) cause the majority of familial and some sporadic forms of Parkinson's disease (PD). The hyperactivity of LRRK2 kinase induced by the pathogenic mutations underlies neurotoxicity, promoting the development of LRRK2 kinase inhibitors as therap...