09/01/2024
At the European Society of Cardiology (ESC) Congress 2024, results from the SELECT trial were presented, highlighting the potential of semaglutide in treating obesity-related diastolic heart failure (HFpEF). Semaglutide, which is already utilized in managing obesity, type 2 diabetes, and cardiovascular risk, is also being investigated for its application in chronic kidney disease (CKD) and peripheral artery disease (PAD).
Presented by Dr. Subodh Verma from the University of Toronto, the trial highlighted these findings:
🔹 Semaglutide led to significant reductions in body weight, waist circumference, and hsCRP levels, particularly among female participants.
🔹 Females with overweight or obesity and atherosclerotic cardiovascular disease (ASCVD) showed a lower risk of major adverse cardiovascular events (MACEs) than males, despite differences in LDL-C, hsCRP, and BMI.
🔹 Although the absolute risk reduction (ARR) was higher in males, semaglutide’s efficacy across cardiovascular, metabolic, and kidney outcomes was consistent across sexes.
🔹 The study also addressed the safety profile of semaglutide, noting that gastrointestinal adverse events were comparable between males and females.
These findings contribute to the understanding of semaglutide’s role in managing complex obesity-related conditions and indicate the need for further research into its broader therapeutic applications.
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