Crystal Pharmacy 麗晶藥房

Crystal Pharmacy 麗晶藥房 Crystal Pharmacy & Medical Supplies is located on the ground floor of Crystal Mall in Burnaby.

We provide our services in English, Mandarin, Cantonese, and Taiwanese, striving to bring the best care and medical knowledge to you and your family. 麗晶藥房及醫療用品中心創立於2007年,位於本拿比麗晶廣場一樓(麗晶里行人道上,往圖書館方向)。

歷年來秉持著專業親切的精神,提供最詳盡的藥物諮詢和最好的服務--因為我們相信您有權了解自己所服用的藥物,得到最完整的醫療知識。我們說普通話、廣東話、閩南話和英語。

07/31/2025

We will be closing on August 4th (Monday), BC Day. Sorry for the inconvenience.
我們會於8月4日(星期一), BC日休息. 不便之處, 敬請原諒

How to prevent mosquito bites? Summer is the perfect season to go out to nature and have fun. But while enjoying nature,...
07/20/2025

How to prevent mosquito bites?
Summer is the perfect season to go out to nature and have fun. But while enjoying nature, mosquito bites can be very annoying. When preparing for outdoor activities, it is recommended that everyone take measures to prevent mosquito bites: try to wear light-colored and long-sleeved clothing, avoid wearing perfume or fragrance that attracts mosquitoes, and spray mosquito repellent beforehand. Early morning and evening are the times when insects like to come out. Therefore, try to avoid activities near water, parks, or forests during these times.
There are many types of mosquito repellent products with similar main ingredients. Most of them contain DEET - one of the oldest traditional mosquito repellents that can effectively protect against mosquitoes, ticks, fleas, and blackfly bites. The higher the concentration of DEET, the longer the protective effect: 5% DEET can provide approximately two hours of protection against mosquitoes, while 30% DEET can provide protection against mosquitoes for up to six hours. DEET is suitable for adults or children over 12 years old. Products with a DEET concentration of 20%-30% can be used up to three times a day.
Another good mosquito repellent option is 20% Icaridin (US name: Picaridin). Icaridin is quite safe, it’s non-greasy and odorless. Unlike DEET, Icaridin does not dissolve plastic or leather, and duration of effect lasts for up to 8 hours - making it the best choice for children from six months to twelve years old. If you can't buy a mosquito repellent with Icaridin, children under two years old can also use a mosquito repellent with 10% DEET up to three times a day (for children under two years old, apply once per day) to prevent
mosquito bites. Children under six months old are not suitable for mosquito repellent. It is recommended to use more clothing and an umbrella for protection.
If you don’t want to use chemical mosquito repellent, a more natural alternative is eucalyptus oil which is suitable for children over three years old and adults. However, its effect only lasts about two hours. Children can also apply soybean oil: Soybean oil is quite safe and can repel mosquitoes for three and a half hours. Unfortunately, natural oil repellents cannot prevent tick bites. Some people have also tried to use lavender oil or citronella essential oil (oil of citronella) to prevent mosquito bites. However, the effect of these natural oils only last about half an hour to two hours. Plus there is not enough research to show the safety of these two essential oils, hence they should not be used by children under the age of two.
If you need to use sunscreen, apply it first and wait 20 minutes to make sure it is absorbed by your skin before spraying on your mosquito repellent. Because DEET can also cause slight neurotoxicity, do not use excessive amounts of it for an extended period of time, or apply it directly to open wounds or mucosal tissue. Furthermore, it is recommended to wash off the mosquito repellent with water and soap after returning home. When used appropriately, mosquito repellent can be a great outdoor companion in summer.
When traveling abroad, proper anti-mosquito bite measures can effectively reduce the risk of contracting dengue fever, West Nile virus, Lyme disease, Malaria, and other infectious diseases. The Zika virus, which is mainly transmitted by vector mosquitoes, may cause neonatal microcephaly. This virus is prevalent in China, South America, Africa, and Southeast Asia. The World Health Organization (WHO) is currently strongly recommending pregnant women
avoid traveling to virus-endemic areas unless necessary. Taking adequate measures to prevent mosquito bites when going on a trip allows you and your family to have a fun and healthy vacation!

如何防蚊蟲叮咬?夏天是適合出外遊玩的季節,但在享受大自然之時,受蚊蟲叮咬也甚是惱人。若是準備去戶外活動,建議大家做好防蚊蟲措施,儘量穿著淺色的長袖衣物,少用容易吸引蚊蟲的香水或香精,並事先噴灑防蚊液。清晨與傍晚都是昆蟲喜好出沒的時間,如果可...
07/20/2025

如何防蚊蟲叮咬?

夏天是適合出外遊玩的季節,但在享受大自然之時,受蚊蟲叮咬也甚是惱人。若是準備去戶外活動,建議大家做好防蚊蟲措施,儘量穿著淺色的長袖衣物,少用容易吸引蚊蟲的香水或香精,並事先噴灑防蚊液。清晨與傍晚都是昆蟲喜好出沒的時間,如果可以,盡量避免此時在水邊、公園或森林中活動。

防蚊蟲劑產品種類眾多,其實主要成份大同小異,大多含待乙妥(DEET),也就是歷史最悠久的傳統防蚊蟲劑之一,可有效防禦蚊子、蜱蟲(ticks)、跳蚤(fleas)、黑蠅(blackflies)叮咬。濃度越高,防護效果越持久:5% DEET大約可以持久兩小時,而30% DEET防蚊時間可達六小時。成人或十二歲以上孩童可使用含20%-30% DEET濃度的產品,一天最多使用三次。

另一個好的選擇是含20% Icaridin(美國名:Picaridin)的防蚊蟲劑。由於Icaridin相當安全、不油不臭、沒有DEET會溶解塑膠或皮革的問題,又最多可持久至8小時,它同時也是六個月至十二歲孩童的最佳選擇。若無法買到Icaridin給十二歲以下孩童防蚊蟲,也可使用10% DEET,一天最多塗三次(兩歲以下孩童則是一天最多一次) 。六個月以下的孩童則不適用防蚊蟲劑,建議多利用衣物、帳幕來防蚊蟲。

如果不想使用化學防蚊劑,有些人會選擇天然的桉樹油(eucalyptus oil),適合三歲以上兒童和成人使用,但是效果只能維持兩小時左右。小朋友們也可以塗抹大豆油(soybean oil):大豆油相當安全,而且防蚊效果可以達三個小時半,可惜的是這些天然油類防蚊劑都無法防止蜱蟲叮咬。也有些人嘗試薰衣草油或香茅精油(oil of citronella)來防蚊,效果只能維持大約半小時至兩小時,但是由於沒有足夠研究顯示安全性,兩歲以下的兒童都不可使用這兩種精油。

如果有需要使用防曬乳,先將防曬乳塗上,等二十分鐘後確定皮膚吸收完畢再噴上防蚊蟲劑。DEET可造成些微神經毒性,因此切勿長期使用過多,或塗抹於傷口、黏膜組織上,並建議回家後用清水與肥皂將噴過防蚊劑的皮膚洗淨;適當的使用則是夏天的防蚊蟲良伴。

出國旅遊時,做好防蚊蟲措施可以有效降低感染登革熱、西尼羅河病毒、萊姆病、瘧疾等傳染病的風險。由於主要靠病媒蚊傳染的茲卡病毒(Zika virus)流行於中南美洲、非洲和東南亞地區,並可能造成新生兒小頭畸形症,世界衛生局(WHO)目前強烈建議孕婦如非必要,盡量避免前往病毒流行地區。一家大小出外旅遊或遠足時做好防蚊蟲措施,才能玩得盡興、玩得健康!

We will be closing on July 1st Canada Day, Tuesday. (We open Jun 30th, Monday, at regular business hours).我們會於7月1日加拿大日,星...
06/28/2025

We will be closing on July 1st Canada Day, Tuesday. (We open Jun 30th, Monday, at regular business hours).
我們會於7月1日加拿大日,星期二,休息. (我們於6月30日,星期一,照常營業)

Tips for Sun ProtectionSummers in Vancouver have always been beautiful but the strong sun and high temperature can cause...
06/11/2025

Tips for Sun Protection

Summers in Vancouver have always been beautiful but the strong sun and high temperature can cause a lot of damage on your skin. It’s important to know how to protect yourself and your family against UV while doing all the summer fun activities.

There are 3 types of UV lights:
UVA (320-400nm): The wavelength that accounts for the largest proportion of ultraviolet rays that reach the earth and is irradiated all day long. It can pe*****te through glass and clothing, and reach deep into the dermis of the skin, causing skin aging, sunburn, skin cancer, etc.
UVB (290-320nm): The main culprit of sunburn, which can also lead to skin aging, skin cancer and more, is usually strongest between 10am and 4pm.
UVC (270-290nm): Almost all of it is absorbed by the ozone layer and does not reach the earth's surface.

How to choose sun protection products
With so many sunscreens on the market, how do you choose one? Every sunscreen product usually lists its ingredients on the bottle, which are mainly divided into two types: physical sunscreen and chemical sunscreen ingredients.

The most common physical sunscreen ingredients are titanium dioxide and zinc oxide, which can form a barrier to directly reflect ultraviolet rays; they are less irritating to the skin, but they are thicker and oilier when applied.

There are currently more than ten kinds of chemical sunscreen ingredients that absorb ultraviolet rays. Although it is relatively refreshing, it is also more likely to cause allergies.

Various chemical sunscreen ingredients can prevent different wavelengths of ultraviolet rays: some only protect against UVB, while others protect against UVB and some UVA... Therefore, most products contain multiple sunscreen ingredients to achieve the best effect. It is recommended that you check whether the sunscreen label is marked with "Broad-spectrum" (that is, UVA and UVB protection at the same time), preventing sunburn (UVB) and dark spots or skin lesions (UVA).

Because children's skin is more sensitive, products with a higher proportion of physical sunscreen ingredients are relatively safer. In addition, some drugs can make the skin particularly sensitive to UVA rays (photosensitivity), such as quinolone antibiotics or sulfa drugs (including the common diuretic and antihypertensive drug hydrochlorothiazide), etc... If you have to take these drugs, then broad-spectrum effect Sunscreen will be your best choice. Just making a decision based on SPF is not enough!

Steps for sun protection
To achieve best sun protection effect, 15-30 minutes before going out during the day, apply a broad-spectrum, SPF30 or above sunscreen on the face, neck, hands, feet, etc.

Apply a decent amount of sunscreen, adults need about 30 grams each time. Reapplication is also required after sweating or swimming. Sunscreen is not suitable for babies under six months old. Instead, use umbrellas, clothing, hats and other items to help prevent sun protection. If there are mosquitoes in the place where you go out, you should apply the sunscreen first, make sure it is absorbed into the skin, and then spray the mosquito repellent.

With proper sun protection, the whole family can enjoy the beauty of Vancouver’s summer without any worries!

如何做好防曬?夏日炎炎,溫哥華的氣溫持續升高,又是全家到海灘享受陽光和戲水的季節了――同時也別忘了做好防曬,提防紫外線對皮膚的傷害!防曬基本小常識紫外線以波長長短可分為3種:UVA (320-400nm): 抵達地球的紫外線中佔最大比例的波...
06/11/2025

如何做好防曬?

夏日炎炎,溫哥華的氣溫持續升高,又是全家到海灘享受陽光和戲水的季節了――同時也別忘了做好防曬,提防紫外線對皮膚的傷害!

防曬基本小常識

紫外線以波長長短可分為3種:

UVA (320-400nm): 抵達地球的紫外線中佔最大比例的波長,全天性照射,可穿透玻璃及衣物、深達皮膚的真皮層,導致皮膚老化、曬黑曬傷、皮膚癌等。
UVB (290-320nm): 曬傷的主要元兇,也可導致皮膚老化、皮膚癌等,通常早上10點至下午4點之間最強。
UVC (270-290nm): 幾乎盡數被臭氧層吸收,不會抵達地球表面。

防曬系數(Sun protection factor,簡稱SPF): 測量防UVB曬傷的數值。擦上SPF30的防曬霜後,比較起沒有擦防曬霜的皮膚,需要曝曬三十倍的時間才會曬紅。

如何挑防曬霜?

市面上的防曬霜種類五花八門,該怎麼選擇呢?每樣防曬霜產品通常會在瓶子上列出它的成分,主要分為兩種:物理性防曬,與化學性防曬成分。

物理性防曬成分最常見到的是titanium dioxide和zinc oxide,可形成屏障直接反射紫外線;對皮膚刺激小,但是擦起來質地較厚較油。化學性防曬成分則有十多種,以吸收紫外線的方式防曬,雖然比較清爽,但也較容易引起過敏。

各種化學性防曬成分能防止的紫外線波長都不盡相同:有些只防UVB,有些則防UVB與部分UVA…因此大多數產品都含多種防曬成分,以達到最佳效果。建議您看清楚防曬霜標籤上是否標有「Broad-spectrum」 (廣效性,即同時防UVA與UVB)字樣,防止曬傷(UVB)的同時也防止黑斑或皮膚病變(UVA)。

由於兒童皮膚較敏感,通常物理性防曬成分比重較高的產品相對來得安全。另外,有些藥物會使皮膚對UVA紫外線特別敏感(photosensitivity),例如奎諾酮類抗生素或磺胺類藥物(包括常見的利尿降壓藥hydrochlorothiazide)等等…若您平時有服用這些藥物,廣效性防曬霜是您的最佳選擇。光是看SPF是不夠的喔!

防曬標準步驟

白天外出前15-30分鐘建議於臉、脖子、手、腳等沒有衣物遮蔽的皮膚上塗抹廣效性、SPF30或以上的防曬霜,並在曝曬後15-30分鐘再塗抹一次,以達最佳防曬效果。

防曬霜的用量不可吝嗇,成人每次需要約30公克的份量。流汗或游泳後也需要重新塗抹。防曬霜不適用於六個月以下的嬰兒,建議多使用遮陽傘、衣物、帽子等物件幫助防曬。如果外出的地方蚊蟲很多,應先塗抹完防曬霜、確定吸收進皮膚後,再噴灑防蚊劑。

做好防曬的完備功課,全家才能無憂無慮地在外享受溫哥華夏季的美好!

Kleiman, N. Prevention and Treatment of Sun-Induced Skin Damage. Patient Self-Care, 2nd ed. Nov. 2012.

05/15/2025

We will be closing on May 19th (Monday), Victoria Day. Sorry for the inconvenience.
我們會於5月19日(星期一), 維多利亞日休息. 不便之處, 敬請原諒

Achooo!! How to manage hay fever symptoms?Birds are chirping, flowers are blooming, and the nuisance of hay fever is bac...
04/09/2025

Achooo!! How to manage hay fever symptoms?

Birds are chirping, flowers are blooming, and the nuisance of hay fever is back along with the beautiful spring season. Hay fever, also known as allergic rhinitis or seasonal allergy, can cause runny and/or itchy nose, congestion, sneezing, red eyes, fatigue, and sometimes even a dry cough. Although some of the symptoms of allergic rhinitis are similar to those of the common cold, allergic rhinitis sufferers often have an itchy nose or eyes, accompanied by watery colorless nasal discharge. When someone has a cold, the nose is usually not itchy, and the nasal discharge is often thick or yellow-green in color, and often a sore throat and cough would be present. Compared to a cold that usually lasts around 1 week, the duration of allergic rhinitis is determined by the allergens, and symptoms disappear once the allergens are removed. In addition to spring and summer pollen and grass seeds, which can cause seasonal allergic rhinitis, dust mites, molds, pet hair or saliva in the home can also cause allergic rhinitis throughout the year.

To deal with allergens at home, you must regularly vacuum, wash bed sheets, pillowcases, curtains and stuffed animals in hot water, and stow away furniture or home decors that are prone to accumulating dust. For those who are allergic to pollen or grass clippings, it is advisable to keep windows and doors closed to prevent pollen from coming into the house from the outside. When you return home after a day out, you can wash your hair or take a shower to remove any allergens that may have stuck to your body, and it is also a good idea to use an air purifier at home.

The most common over-the-counter medications for allergic rhinitis are antihistamines, including first-generation antihistamines (e.g., Diphenhydramine or Benadryl) and second-generation antihistamines (Reactine, Claritin, Aerius, Allegra). These medications are effective against almost all allergic rhinitis symptoms involving the eyes and nose (unfortunately, they are weak against nasal congestion, with the exception of Aerius, which is a bit more effective for stuffy nose), and are usually taken once daily, with the effect lasting 12 to 24 hours. Although it only takes around 1 hour for the medication to start working, the most effective way of preventing allergy symptoms is to take the medication BEFORE symptoms start and to continue taking it until the end of the pollen season. Around 1 to 2 people out of 10 Reactine users will become sleepy, otherwise all second generation antihistamines do not cause drowsiness. In contrast, the first generation antihistamines can cause people to be very drowsy, and may also cause dry mouth or rapid heartbeat, hence making it not suitable for people who need to work, drive, or go to school. Thus the second generation antihistamines are usually recommended over first generation antihistamines for allergic rhinitis.

So which allergy medication is the best? In fact, many patients may find that the brand that worked for them last year may not necessarily work for them this year, and the allergens that people are sensitive to may change year to year. Everyone’s reaction to different antihistamine medications may be different, so the only way to find out which one works the best for you is to try them out one by one. It is worth noting that some of the second generation antihistamine products labeled with "sinus" have decongestants added in them. Although these can temporarily relieve nasal congestion, they are not suitable for patients with cardiovascular disease, high blood pressure, prostate problems, closed angle glaucoma, or hyperthyroidism due to the possible side effects of palpitations, elevated blood pressure and urinary retention. Reactine, Claritin and Aerius can all be given to children above 2 years old; the latter two products are also available in syrup forms.

In addition to oral medications, nasal sprays or eyedrops may also be used. Decongestant nasal sprays, such as Otrivin, can temporarily constrict the blood vessels in the nasal cavities, which is a quick and effective way to relieve nasal congestion. However, it is important not to use these sprays for more than three to seven days, as this may cause a rebound effect after discontinuing their use, which may worsen the symptoms of stuffy nose. The same applies to decongestant eyedrops: eyedrops labeled "red eye" usually contain decongestants, which can temporarily reduce the amount of redness in the eyes, but as they do not combat itchy or watery eyes and may cause rebound effects, their use is not recommended.

If itchy eyes are the main problem, one may try over-the-counter Cromolyn eyedrops. They are very safe and have no side effects, and are suitable for children over 2 years of age as well as adults. However, as they are milder and slower-acting than antihistamines, they are only suitable for mild symptoms, and may take up to three days to alleviate the symptoms. Starting June 2023, pharmacists in B.C. can also prescribe prescription anti-allergy medications such as antihistamine eyedrops (e.g. Patanol, Pataday) and corticosteroid nasal sprays (Nasonex, Flonase, Omnaris, Avamys, Beclomethasone, etc.). Although nasal sprays take up to two weeks to be fully effective, they are more effective than oral anti-allergy medications, and most of them can be used by children. If you are a B.C. resident with valid MSP, you are welcome to consult with your pharmacist to see if these prescription allergy medications are suitable for you.

哈啾!如何選對花粉症成藥鳥兒啾叫、百花怒放,擾人的花粉症也隨著溫哥華的好天氣一起回來了。花粉症(Hay fever)又稱過敏性鼻炎(allergic rhinitis),症狀包括流鼻涕、鼻塞、打噴嚏、眼睛充血發癢、流眼淚、疲勞,有時鼻涕倒流...
04/09/2025

哈啾!如何選對花粉症成藥

鳥兒啾叫、百花怒放,擾人的花粉症也隨著溫哥華的好天氣一起回來了。花粉症(Hay fever)又稱過敏性鼻炎(allergic rhinitis),症狀包括流鼻涕、鼻塞、打噴嚏、眼睛充血發癢、流眼淚、疲勞,有時鼻涕倒流還可導致乾咳。過敏性鼻炎雖然有些症狀與普通感冒相似,但花粉症患者經常鼻子或雙眼發癢、伴隨大量無色稀釋的鼻水,有時會有眼袋水腫或黑眼圈等特徵;感冒患者沒有發癢的症狀,而鼻水常是濃稠或呈黃綠色,並常伴有喉嚨痛、咳嗽等其他症狀。相較於為期一週的傷風,過敏性鼻炎的持續時間是由過敏源而定,一旦移除過敏源,症狀便會消失。除了春夏天無孔不入的花粉、草籽等可造成季節過敏性鼻炎,家中的塵蟎、霉菌、寵物的毛髮或唾液更是可以引起全年性過敏性鼻炎。

對付家中的過敏源必須勤快每週吸塵,用熱水定期清洗床單、枕套、窗簾、填充玩偶,並儘量維持家中環境乾燥,將易堆積灰塵的家具擺飾收進儲藏室中,減低與過敏源的接觸。對花粉或草絮過敏者,宜保持門窗關閉以防花粉從外飄進屋內,外出後回到家時可洗頭或沖澡、將黏附在身上的過敏源洗淨,平時在家使用空氣過濾器也不失為一個好辦法。

藥房最常見的過敏性鼻炎成藥是抗組織胺藥物(antihistamines),又分第一代(如:Diphenhydramine,或Benadryl)與第二代(Reactine、Claritin、Aerius)。這些成藥對過敏性鼻炎幾乎所有眼睛與鼻腔的症狀有效(可惜對抗鼻塞效果薄弱,唯有Aerius這方面稍強),通常一天一粒,效果維持十二至二十四小時,雖然約服用後一小時便起作用,最有效的方式是在症狀還沒開始之前就使用,並持續服用至花粉季節結束,以達成預防效果。除了約十分之一至五分之一的Reactine使用者會昏沉嗜睡,其他第二代抗組織胺藥物通常不會有這類副作用。相較之下,第一代抗組織胺會令人相當昏昏欲睡或伴有其他口乾或心跳加快的現象,不適合需要工作或開車者服用,也有可能影響孩童學習,因此通常建議過敏性鼻炎患者使用第二代抗組織胺藥物。

如何在這麼多種品牌裡選擇適合自己的過敏藥呢?其實許多患者會發現,去年對自己有效的牌子,今年不一定見效,而有些患者所敏感的過敏源也有可能隨著自身的免疫系統變化而改變,每人對不同抗組織胺藥物的反應也不盡相同,只有一一嚐試才能知曉。值得注意的是,有些標榜『Sinus』的第二代抗組織胺產品有加解充血劑(decongestants),雖然可暫時抗緩鼻塞,由於副作用包含心悸、血壓升高、尿滯留,不適合心血管疾病、高血壓、前列腺肥大、閉角式青光眼、或甲狀腺機能亢進之患者使用。

家長可能會問:兒童可以服用第二代抗組織胺藥物嗎?Reactine、Claritin、Aerius皆可給兩歲以上的兒童服用,後兩者更是有專為兒童設計的糖漿。劑量依年齡或體重調整,請諮詢您的藥劑師或家庭醫生。

除了口服藥以外,症狀尚輕的患者也可使用噴鼻液或眼藥水。解充血劑的噴鼻液如Otrivin可暫時使鼻膜血管收縮、對抗鼻塞迅速有效,但切忌連續使用超過三至七天,以防停止使用後造成反彈作用、加重鼻塞症狀。同樣的道理適用於解充血劑的眼藥水:通常藥房櫃上擺著標榜『Red Eye』(抗紅眼症)的眼藥水都含有解充血劑,雖然能暫時減少眼中血絲,卻無法對抗眼睛發癢或流淚的症狀,也可能導致反彈作用,並不建議使用。

若患者主要症狀是在於眼睛,可以嘗試非處方的色甘酸钠眼藥水(Cromolyn eyedrops),由於非常安全並且幾乎沒有副作用,適合兩歲以上的孩童和成人,但是由於藥效比抗組織胺藥物較弱且發揮緩慢,只適用於輕微症狀,並須時三天才可舒緩症狀。自2023年6月開始,BC省的藥劑師也可以開處方等級的抗過敏藥,譬如抗組織胺眼藥水(如Patanol、Pataday),以及類固醇噴鼻液(Nasonex、Flonase、Omnaris、Avamys、Beclomethasone等)。雖然噴鼻液需時兩星期才能完全發揮藥效,但比口服抗過敏藥更加有效,且大多產品兒童皆可使用。如果您是BC省民並且有MSP,歡迎諮詢您的藥劑師問診,看看是否適合使用這些處方等級的抗過敏藥。

在這個季節變換的時刻,為了不必涕淚縱橫、噴嚏連連也能盡情在陽光下享受戶外活動,建議每年有相同煩惱的過敏性鼻炎患者和家庭醫生攜手找出控制症狀的最佳方案。

Osteoporosis treatment: oral Bisphosphonates vs Denosumab subcutaneous injections 1,2,3,4,5,6,7After the age of 40, our ...
02/26/2025

Osteoporosis treatment: oral Bisphosphonates vs Denosumab subcutaneous injections 1,2,3,4,5,6,7

After the age of 40, our bones begin to lose calcium faster than they absorb it, and the gap widens with age, causing osteoporosis. This is the reason why some elderly people are shorter than when they were young. Osteoporosis greatly increases the risk of bone fractures, which not only cause pain and extreme inconvenience, but also increases fatalities after falling. To prevent or delay osteoporosis, supplementing with enough calcium and vitamin D every day is the first step. But if despite taking enough calcium and vitamin D, osteoporosis still occurs after a bone density test, the doctor will start the patient on prescription medications. There are several types of medications that can be used to treat osteoporosis. Due to space limitations, this article only focuses on the two most effective and most commonly used types of medications.

Biphosphonate oral medications: Alendronate (FosamaxⓇ), Risedronate (ActonelⓇ)
Our bones are living organs, constantly shedding aging bone cells and building new bone cells. Within our bones, osteoBlast cells absorb calcium from the blood to create new bone cells, while osteoClast cells remove aging bone cells to allow new bones to grow. Bisphosphonates can inhibit the operation of osteoclasts, thereby reducing the chance of bone cell loss.

There is sufficient data to show that bisphosphonates can increase bone density by 1.6% to 7% after three years of use, and can reduce the risk of bone fractures by 20% to 50%.

Bisphosphonates are usually taken once a week (the long-acting version of Risedronate can be taken once a month), and must be taken on an empty stomach. It is recommended not to lie down within half an hour after taking it to avoid the side effect of acid reflux. Most side effects are limited to gastrointestinal discomfort, and the chance of causing fractures or jaw necrosis is extremely low (the chance is 4.5/10,000).

After long-term use, bisphosphonates can remain in the bones and exert their effects for one to ten years. Therefore, you can discuss with your doctor after taking them for three to five years. If the results of the bone density test are satisfactory three to five years after taking bisphosphonate, you can consult with your doctor if you can stop taking bisphosphonate until the next bone density test

Denosumab: ProliaⓇ, JubbontiⓇ
Denosumab is a monoclonal antibody that prevents osteoclasts from maturing. After three years of treatment, bone density can usually be increased by 5.2% to 8.8%, and the risk of bone fractures can be reduced by 20% to 68%.

Denosumab is injected subcutaneously every six months and can be administered at a clinic or community pharmacy. Side effects are usually mild (fatigue, muscle pain), and most patients experience almost no side effects after the injection. The chance of fracture or jaw osteonecrosis is also extremely low (28/10,000).

Unlike bisphosphonates, the efficacy of denosumab can only last for six months. If denosumab therapy stopped for more than a year, the rate of osteoporosis will begin to accelerate. Therefore, denosumab treatment should not be stopped casually after starting.

Bisphosphonates and denosumab are both very effective in reducing the risk of fractures, with denosumab seems to have a slightly better outcome. However, denosumab is more expensive, about $250 per dose (bisphosphonates: about $60 to $120 per half year). As for bisphosphonate, those who are prone to acid reflux and stomach pain should avoid taking it. Patients who need medication to deal with osteoporosis can consult a doctor.

https://www.ncbi.nlm.nih.gov/books/NBK470248/
https://www.osteoporosis.foundation/health-professionals/treatment/bisphosphonates
Int J Clin Pract.2012 Dec;66(12):1139-46. doi: 10.1111/ijcp.12022. Epub 2012 Sep 12.
https://doi.org/10.1016/8756-3282(95)00445-9
https://www.drugs.com/medical-answers/prolia-increase-bone-density-3553495
N Engl J Med 2009;361:756-765/DOI: 10.1056/NEJMoa0809493/VOL. 361 NO. 8
https://www.healio.com/news/endocrinology/20220329/risk-for-osteonecrosis-of-the-jaw-higher-with-denosumab-vs-bisphosphonates #:~:text=A%20total%20of%203%2C068%20adults,patient%2Dyears%20for%20denosumab%20therapy.

骨質疏鬆治療: 雙磷酸鹽口服藥vs地諾單抗皮下注射1,2,3,4,5,6,7我們從40歲之後, 骨頭流失鈣的速度開始超出吸收鈣的速度, 隨著年齡增長而差距越大, 造成骨質疏鬆. 有些長者身高比年青時矮正因如此. 骨質疏鬆會大大增加骨裂的風險...
02/26/2025

骨質疏鬆治療: 雙磷酸鹽口服藥vs地諾單抗皮下注射1,2,3,4,5,6,7

我們從40歲之後, 骨頭流失鈣的速度開始超出吸收鈣的速度, 隨著年齡增長而差距越大, 造成骨質疏鬆. 有些長者身高比年青時矮正因如此. 骨質疏鬆會大大增加骨裂的風險, 而骨裂除了造成痛楚及生活上極度不便之外, 更會增加病者跌倒後死亡的機會. 要預防/舒緩骨質疏鬆, 每天補充足夠的鈣及維他命D固然是首要, 但若之後檢查骨質密度後仍出現骨質疏鬆, 醫生便會開處方藥給病者服用. 能用於骨質疏鬆治療的藥物有好幾種, 篇幅所限, 本篇只集中討論效果最好及最常用的兩類藥物

Biphosphonate 雙磷酸鹽口服藥: Alendronate(FosamaxⓇ), Risedronate (ActonelⓇ)
在正常新陳代謝過程中,骨骼內有OSTEOBLAST(成骨細胞)從血液攝取鈣質後製造新的骨骼細胞, 而OSTEOCLAST(蝕骨細胞)會去掉老化的骨骼細胞, 讓新的骨骼有空間生長. 雙磷酸鹽能抑制蝕骨細胞的運作, 從而減少骨骼細胞流失的機會.

有充足資料顯示雙磷酸鹽在服用三年後能提升骨骼密度1.6%至7%, , 能減低骨裂風險20%至50%

雙磷酸鹽通常一星期服一次 (Risedronate 長效版更可一個月服一次), 必須空腹服用, 服後半小時內建議不要躺下以避免胃酸反流的副作用. 副作用大部份限於腸胃不適, 引起骨折或顎骨壞死的機會極低(機會率4.5/10,000)。

雙磷酸鹽在長期服用後有何能藏在骨骼內發揮藥效一至十年,所以可以在服用三至五年後與醫生商量,如骨質密度檢查結果滿意的話, 是否可以暫停服用, 在三至五年後再跟據骨質密度去決定是否需要重新服用。

Denosumab 地諾單抗: ProliaⓇ, JubbontiⓇ
Denosumab 是單株抗體, 能防止蝕骨細胞成熟. 接受治療三年後通常能提升骨骼密度5.2%至8.8%, 能減低骨裂風險20%至68%

地諾單抗是皮下注射, 每六個月一次, 可選擇在醫務所或社區藥房接受注射. 副作用通常十分溫和 (疲倦, 肌肉痛), 大部分病者接受注射後幾乎沒有任何副作用, 引起骨折或顎骨壞死的機會也是極低(28/10,000)。

與雙磷酸鹽不一樣,地諾單抗藥效只能維持六個月, 如超過一年沒有注射地諾單抗, 骨質疏鬆速度便會開始加劇, 故開始地諾單抗療程後通常不能隨便停用

雙磷酸鹽及地諾單抗對於減低骨折風險效果都十分好, 以地諾單抗似乎略勝一籌, 但地諾單抗價錢會比較貴, 約$250一劑 (雙磷酸鹽: 約$60至$120 半年). 另外, 容易本身有胃酸倒流及胃痛的亦應避免服用. 需要用藥來應付骨質疏鬆的病者可與醫生諮詢應用那一種藥.

https://www.ncbi.nlm.nih.gov/books/NBK470248/
https://www.osteoporosis.foundation/health-professionals/treatment/bisphosphonates
Int J Clin Pract.2012 Dec;66(12):1139-46. doi: 10.1111/ijcp.12022. Epub 2012 Sep 12.
https://doi.org/10.1016/8756-3282(95)00445-9
https://www.drugs.com/medical-answers/prolia-increase-bone-density-3553495
N Engl J Med 2009;361:756-765/DOI: 10.1056/NEJMoa0809493/VOL. 361 NO. 8
https://www.healio.com/news/endocrinology/20220329/risk-for-osteonecrosis-of-the-jaw-higher-with-denosumab-vs-bisphosphonates #:~:text=A%20total%20of%203%2C068%20adults,patient%2Dyears%20for%20denosumab%20therapy.

01/21/2025

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1611-4500 Kingsway
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V5H2A9

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Tuesday 9:45am - 6:30pm
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