05/28/2026
M**A and L*D are often grouped together in public conversations about psychedelics—but the experiences they produce are commonly described in very different ways.
Research suggests that M**A is more often associated with emotional openness, empathy, connection, sociability, and positive mood, while L*D is more commonly linked to altered perception, visual and sensory changes, introspection, and shifts in consciousness.
Understanding these differences is important when discussing research, therapeutic models, and how different substances may affect people in different ways. While they are sometimes discussed under the same umbrella, they are not interchangeable experiences.
Experiences can vary based on the person, dose, environment, and level of support provided. Research in this area is still evolving.
What comparison should we break down next?
📖 Source:
Holze F, Vizeli P, Ley L, Müller F, Dolder P, Stocker M, Duthaler U, Varghese N, Eckert A, Borgwardt S, Liechti ME. Distinct acute effects of L*D, M**A, and D-amphetamine in healthy subjects. Neuropsychopharmacology. 2020;45(3):462–471. https://doi.org/10.1038/s41386-019-0569-3